Buffers, Detergents & Protease Inhibitors

Cat. No.

A11901

CAS No.

329-98-6

PMSF

Synonyms: Benzylsulfonyl fluoride

PMSF is an irreversible serine/cysteine protease inhibitor.

Cat. No.

A14263

CAS No.

9087-70-1

Aprotinin

Synonyms: BPTI ,Bovine Pancreatic Trypsin Inhibitor

Aprotinin is a small protein serine protease inhibitor, used to reduce perioperative blood loss and transfusion.

Cat. No.

A14270

CAS No.

30827-99-7

AEBSF HCl

AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.

Cat. No.

A10854

CAS No.

13721-39-6

Sodium orthovanadate

Sodium orthovanadate is the chemical compound Na3VO4. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

Cat. No.

A10958

CAS No.

58970-76-6

Ubenimex (Bestatin)

Synonyms: NK 421; Bestatin; NSC 265489

Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells.

Cat. No.

A13257

CAS No.

66701-25-5

E-64

E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.

Cat. No.

A14145

CAS No.

103476-89-7

Leupeptin hemisulfate

Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain.

Cat. No.

A14262

CAS No.

26305-03-3

Pepstatin A

Synonyms: Pepstation-A

Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication.

Cat. No.

A22323

CAS No.

1670-14-0

Benzamidine hydrochloride

Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively.

Cat. No.

A24116

CAS No.

154804-51-0

β-Glycerophosphate disodium salt hydrate

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a widely used phosphatase inhibitor. It plays a critical role in promoting and sustaining osteoblast differentiation, supporting mineral metabolism, and modulating cellular signal transduction pathways. In tissue engineering and drug delivery, it is commonly utilized as a component in the formation of heat-sensitive hydrogels due to its thermoresponsive properties. Additionally, β-glycerophosphate disodium salt accelerates calcification in vascular smooth muscle cells, making it a valuable tool for studying vascular calcification and related pathologies.

Cat. No.

A36168

CAS No.

13408-09-8

β-Glycerophosphate disodium salt pentahydrate

β-Glycerophosphate disodium salt pentahydrate is a potent phosphatase inhibitor that plays a crucial role in osteoblast differentiation, mineral metabolism, and signal transduction. This bioactive metabolite is instrumental in promoting the calcification of vascular smooth muscle cells and offers applications as a drug carrier for the development of heat-sensitive hydrogels. Its diverse biological activities make it valuable for research in bone biology and vascular health.

Cat. No.

A39629

CAS No.

28575-34-0

Pepstatin acetate

Synonyms: Pepstatin A acetate

Pepstatin acetate is a potent aspartic protease inhibitor derived from actinomycetes, exhibiting a range of IC50 values, including 4.5 nM for hemoglobin-pepsin and 6.2 nM for hemoglobin-proctase. It selectively inhibits various proteolytic activities, including those of casein-pepsin and HIV protease. This compound is valuable for studies investigating protease function and inhibition, with potential applications in enzyme regulation, cancer research, and HIV treatment.

Cat. No.

A39832

CAS No.

55123-66-5

Leupeptin

Leupeptin is a membrane-permeable broad-spectrum protease inhibitor that effectively targets serine, cysteine, and threonine proteases. This compound has been shown to inhibit the main protease of SARS-CoV-2 (Mpro) while also exhibiting anti-inflammatory properties. Leupeptin is valuable for research applications involving proteolytic processes and can aid in the study of viral infections and inflammatory responses.

Cat. No.

A46327

CAS No.

65391-42-6

Bestatin hydrochloride

Synonyms: Ubenimex hydrochloride

Bestatin hydrochloride is an inhibitor of aminopeptidase N (CD13) and leukotriene A4 hydrolase. It plays a significant role in cancer research by modulating the enzymatic activities associated with tumor progression and inflammatory processes. This compound is valuable for studies investigating the implications of aminopeptidases in tumor microenvironments and immune responses.

Cat. No.

A47557

CAS No.

223763-80-2

Bestatin trifluoroacetate

Synonyms: Ubenimex trifluoroacetate

Bestatin trifluoroacetate is a potent inhibitor of CD13 (Aminopeptidase N) and leukotriene A4 hydrolase. It plays a significant role in cancer research by modulating enzymatic activity associated with tumor progression and inflammation. With its capability to interfere with amino acid metabolism, Bestatin trifluoroacetate is valuable for studying the biological processes linked to these targets.

Cat. No.

A77651

CAS No.

618-39-3

Benzamidine

Benzamidine is a competitive protease inhibitor targeting enzymes such as plasmin, trypsin, and thrombin, effectively preventing the hydrolytic cleavage of glucagon. It is primarily employed to stabilize glucagon in human plasma and blood samples during collection, storage, and analysis, thereby ensuring accurate detection outcomes in research applications. While Benzamidine can induce slight single-strand DNA breaks at elevated concentrations, it demonstrates minimal overall genotoxicity. Additionally, it may interfere with certain glucagon antisera, although it does not significantly impact the affinity of key antigen-antibody interactions at specific concentrations.

Cat. No.

A77657

CAS No.

206752-36-5

Benzamidine hydrochloride hydrate

Synonyms: Benzenecarboximidamide hydrochloride hydrate

Benzamidine hydrochloride hydrate is a reversible competitive inhibitor of serine proteases, specifically targeting trypsin-like enzymes. It exhibits inhibitory constants (Kis) of 20 μM for Tryptase, 21 μM for Trypsin, 97 μM for uPA, 110 μM for Factor Xa, 320 μM for Thrombin, and 750 μM for tPA. This compound is widely utilized in biochemical research to study proteolytic processes and enzyme activity related to various physiological and pathological conditions.