Assay Controls & Cell Stimulation

Cat. No.

A12373

CAS No.

187389-52-2

Z-VAD-FMK

Synonyms: Z-VAD(OMe)-FMK

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

Cat. No.

A11043

CAS No.

133407-82-6

MG-132

Synonyms: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO

MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).

Cat. No.

A10036

CAS No.

66-81-9

Cycloheximide

Synonyms: Actidione

Cycloheximide (also known as actidione) is used as an selective antibiotic. It inhibits the protein synthesis (DNA-dependent RNA) of saprobic fungi eukaryotes. by binding with the 80S ribosome, while inactive against dermatophytes and systemic fungi.

Cat. No.

A13247

CAS No.

347174-05-4

Ferrostatin-1 (Fer-1)

Synonyms: Fer1

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.

Cat. No.

A13822

CAS No.

571203-78-6

Erastin

Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.

Cat. No.

A14427

CAS No.

571190-30-2

Palbociclib (PD-0332991)

Synonyms: PD0332991

Palbociclib is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Cat. No.

A10701

CAS No.

827022-32-2

PD-0332991 HCl (Palbociclib HCl)

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Cat. No.

A10864

CAS No.

62996-74-1

Staurosporine

Synonyms: AM-2282; STS

Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.

Cat. No.

A14437

CAS No.

872573-93-8

Ro 3306

Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively).

Cat. No.

A10669

CAS No.

579-13-5

Oligomycin A

Oligomycin A is a mitochondrial ATPase inhibitor. Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane.

Cat. No.

A11973

CAS No.

4311-88-0

Necrostatin-1

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).

Cat. No.

A10238

CAS No.

64-86-8

Colchicine

Colchicine is an inhibitor of microtubules by specific binding to tubulin.

Cat. No.

A11961

CAS No.

88899-55-2

Bafilomycin A1

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.

Cat. No.

A13219

CAS No.

31430-18-9

Nocodazole

Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.

Cat. No.

A10603

CAS No.

22373-78-0

Monensin sodium

Monensin sodium is an ionophore and inhibitor of autophagy commercially used in livestock feed. It inhibits autophagy, interfering with the fusion of the autophagosome and the lysosome.

Cat. No.

A10811

CAS No.

83-79-4

Rotenone

Rotenone is an mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

Cat. No.

A11156

CAS No.

20350-15-6

Brefeldin A

Brefeldin A blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange.

Cat. No.

A13930

CAS No.

477-30-5

Demecolcine

Synonyms: NSC-3096; Kolchicin; C-12669

Demecolcine is a potent tubulin inhibitor that effectively disrupts microtubule polymerization, exhibiting an IC50 value of 2.4 μM. By binding to tubulin dimers, Demecolcine exerts anti-mitotic effects, hindering cellular division. This compound is primarily utilized in research related to inflammatory disorders and various cancer pathways, making it valuable for studies focused on cell cycle regulation and targeted therapies.

Cat. No.

A14000

CAS No.

1404-19-9

Oligomycin

Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation.

Cat. No.

A16340

CAS No.

161401-82-7

Z-VAD(OH)-FMK

Synonyms: Caspase Inhibitor VI

Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases.

Cat. No.

A16478

CAS No.

154-17-6

2-Deoxy-D-glucose

Synonyms: 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose

2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.

Cat. No.

A17423

CAS No.

50-89-5

Thymidine

Synonyms: AI3-52267

Thymidine is a nucleoside in which THYMINE is linked to DEOXYRIBOSE. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.

Cat. No.

A21960

CAS No.

1784-03-8

TAME hydrochloride

TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest.

Cat. No.

A24147

CAS No.

38966-21-1

Aphidicolin

Aphidicolin is a tetracyclic diterpenoid antibiotic produced by the mold Cephalosporium aphidicola, known for its potent and selective inhibition of DNA polymerase α and δ. By interfering with these polymerases, Aphidicolin blocks DNA synthesis and prevents mitotic cell division, making it a valuable tool for studying cell cycle regulation and DNA replication. In addition to its antiproliferative properties, Aphidicolin inhibits viral DNA synthesis and demonstrates antiviral activity against herpes simplex virus and orthopoxviruses. It also enhances apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cells, suggesting potential in combination therapies for cancer and viral infections. Aphidicolin is widely used in research involving DNA replication stress, antiviral mechanisms, and cell cycle synchronization.

Cat. No.

A31271

CAS No.

17090-79-8

Monensin

Synonyms: Monensin A

Monensin, a polyether antibiotic, functions primarily as an ionophore that mediates Na+/H+ exchange. It has been identified as a potent inhibitor of Wnt signaling, leading to significant enlargement of multivesicular bodies (MVBs) and modulating exosome secretion. This compound is utilized in research focused on bacterial, fungal, and parasitic infections, and it also exhibits anticancer properties, making it a valuable tool in various biological studies.