We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Stem Cell Reprogramming & Differentiation

Stem cell reprogramming and differentiation reagents are small molecules that steer cell identity in culture. Chemical cocktails can replace or support transcription factors when somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs). Frequent components include the histone deacetylase (HDAC) inhibitor valproic acid and the lysine-specific demethylase 1 (LSD1) inhibitor tranylcypromine. RepSox blocks the transforming growth factor beta (TGF-β) type I receptor and can replace the transcription factor Sox2. Inhibition of glycogen synthase kinase 3 (GSK-3) with CHIR-99021 and of MAP kinase kinase (MEK) with PD0325901 keeps mouse embryonic stem cells in the ground state. Differentiation protocols use retinoic acid, the Hedgehog pathway agonists SAG and purmorphamine, and IDE1 for definitive endoderm.

Items 51-53 of 53

  • SAG dihydrochloride
    Cat. No.
    A84824
    CAS No.
    2702366-44-5

    SAG dihydrochloride

    SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist, with an EC50 of 3 nM and a Kd of 59 nM. This compound effectively activates the Hedgehog signaling pathway, providing a robust mechanism to counteract the inhibitory effects of Cyclopamine. SAG dihydrochloride is valuable for research in developmental biology, cancer biology, and therapeutic strategies targeting Hedgehog-related pathways.

    In stock View Details
    1 mg
    $40.00
    5 mg
    $75.00
    All 6 sizes
  • 3i Stem Cell Reprogramming and Maintenance Kit
    Cat. No.
    K10003

    3i Stem Cell Reprogramming and Maintenance Kit

    Synonyms: 3i Cocktail; 3i Kit; CHIR-99021/SU5402/PD184352; iPSC Reprogramming Inhibitor Kit; Ground State Inhibitor Kit; CHIR99021; SU 5402; CI-1040

    A set of three small-molecule inhibitors (CHIR-99021, SU5402 and PD184352) for the reprogramming and long-term maintenance of induced pluripotent stem cells under 3i conditions. One kit supplements up to 3 L of culture medium.

    In stock View Details
    3i Stem Cell Reprogramming and Maintenance Kit 1 Kit
    $180.00
    3i Stem Cell Reprogramming and Maintenance Kit 3 Kits
    $480.00
    All 2 sizes
  • DFICBY Astrocyte-to-Neuron Reprogramming Kit
    Cat. No.
    K10004

    DFICBY Astrocyte-to-Neuron Reprogramming Kit

    Synonyms: DFICBY; DFICBY Cocktail; Astrocyte Reprogramming Kit; Astrocyte to Neuron Kit; Chemical Neuronal Reprogramming Kit

    A six-compound small-molecule cocktail (DFICBY) for the chemical reprogramming of astrocytes into neuronal cells. One kit supplements up to 1 L of culture medium.

    In stock View Details
    DFICBY Astrocyte-to-Neuron Reprogramming Kit 1 Kit
    $470.00
    DFICBY Astrocyte-to-Neuron Reprogramming Kit 3 Kits
    $1,250.00
    All 2 sizes

Items 51-53 of 53

Added to your cart

View Cart Checkout

    Loading...