Solid Tumor Antigens

Cat. No.

AT0869

Anti-CLDN6 Antibody (AB3-7)

Synonyms: AB3-7

Anti-CLDN6 Antibody (AB3-7) is a humanized monoclonal antibody specifically targeting CLDN6, expressed in Chinese Hamster Ovary (CHO) cells. This antibody is composed of an IgG1 heavy chain and a human kappa (huκ) light chain, with a predicted molecular weight of 78.02 kDa. For experimental control purposes, the recommended isotype control is Human IgG1 kappa, Isotype Control, which matches the antibody's subclass and light chain type. This product is essential for research focusing on the role of CLDN6 in cellular and molecular biology studies.

Cat. No.

AT0876

Anti-GPC3 Antibody (YP7)

Anti-GPC3 Antibody (YP7) is a chimeric mouse monoclonal antibody of the IgG1 kappa subclass, specifically designed to target human Glypican 3 (GPC3). For optimal experimental control, the recommended isotype control is Mouse IgG1 kappa, Isotype Control. This antibody is ideal for research applications requiring precise GPC3 targeting.

Cat. No.

AT0881

CAS No.

1824663-82-2

Sirtratumab

Synonyms: AGS15C; Ha15-10ac12; Ha15-10ac12.1

Sirtratumab is a human IgG2 monoclonal antibody specifically targeting SLIT and NTRK-like family 6 (Slitrk6). This antibody is designed for use in cancer research, facilitating the investigation of Slitrk6's role and mechanisms in oncogenesis. Sirtratumab's high specificity makes it a valuable tool for detailed studies focusing on the molecular pathways influenced by Slitrk6 in various cancer models.

Cat. No.

AT0886

Anti-MUC16 Antibody (VK8)

The Anti-MUC16 Antibody (VK8) is a chimeric mouse monoclonal antibody of the IgG1 kappa subclass, designed to specifically target human MUC16. For accurate experimental control, it is recommended to use Mouse IgG1 kappa, Isotype Control as the appropriate isotype control for this antibody.

Cat. No.

AT0913

AMG-119

AMG-119 is a humanized IgG1 monoclonal antibody specifically designed to target delta-like ligand 3 (DLL3). This antibody is particularly useful in research focused on relapsed or refractory small cell lung cancer (SCLC). For accurate experimental control, it is recommended to use Human IgG1 kappa as an isotype control.

Cat. No.

AT0952

CAS No.

1615692-28-8

Sofituzumab

Synonyms: MMUC 1206A

Sofituzumab (MMUC 1206A) is a recombinant, humanized V-kappa antibody targeting MUC16. This monoclonal antibody is designed for high specificity and affinity in binding to the MUC16 antigen, making it a valuable tool for research into cancer diagnostics and therapeutics where MUC16 is a relevant biomarker.

Cat. No.

AT0957

CAS No.

2823329-10-6

Tecotabart

Tecotabart is a humanized IgG1κ monoclonal antibody that specifically targets Claudin 18 (CLDN18). For experimental control purposes, it is recommended to use Human IgG1 kappa as an isotype control.

Cat. No.

AT0962

CAS No.

503605-66-1

Adecatumumab

Synonyms: MT 201; Anti-Human EPCAM Recombinant Antibody

Adecatumumab (MT201) is a fully human monoclonal antibody of the IgG1 isotype designed to specifically target human EpCAM (Epithelial Cell Adhesion Molecule). This antibody is recognized for its broad expression across various adenocarcinomas. Importantly, the efficacy of Adecatumumab is independent of the K-Ras mutation status, making it a versatile tool in the research of carcinomas where EpCAM is a critical factor.

Cat. No.

AT0980

CAS No.

1448664-46-7

Enfortumab

Enfortumab is a humanized antibody targeting Nectin-4, suitable for conjugation with the potent microtubule disruptor, monomethyl auristatin E (MMAE), to form the antibody-drug conjugate (ADC) Enfortumab vedotin. This ADC is specifically designed for research into locally advanced and metastatic urothelial carcinoma, offering a targeted approach to study the therapeutic efficacy and mechanism of action in these cancer models.

Cat. No.

AT0991

Anti-MUC1/CD227 Antibody (C595 (NCRC48))

The Anti-MUC1/CD227 Antibody (C595 (NCRC48)) is a chimeric mouse monoclonal antibody of the IgG3, κ subclass, specifically designed to target human MUC1/CD227. For accurate experimental control, it is recommended to use Mouse IgG3 kappa as an isotype control. This antibody serves as a crucial tool for the detection and study of MUC1/CD227 expression in various research applications.

Cat. No.

AT1002

OS-2966

OS-2966 is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting Integrin β1 (ITGB1/CD29). This antibody is composed of a human IgG1 type heavy chain and a human kappa (huκ) type light chain. The predicted molecular weight of OS-2966 is approximately 145.5 kDa. For experimental control purposes, Human IgG1 kappa, Isotype Control is recommended as the appropriate isotype control for OS-2966. This antibody is pivotal for research focused on cell adhesion, migration, and signaling pathways mediated by Integrin β1.

Cat. No.

AT1010

CAS No.

154361-48-5

Arcitumomab

Arcitumomab is a murine-derived monoclonal antibody fragment (Fab') specifically targeting the carcinoembryonic antigen (CEA). This agent is suitable for conjugation with technetium-99m, facilitating its use in single-photon emission computed tomography (SPECT) imaging to enhance diagnostic accuracy in oncology research.

Cat. No.

AT1015

Osemitamab (FUT8-KO)

Osemitamab is a monoclonal antibody targeting claudin-18.2, expressed in Chinese Hamster Ovary (CHO) cells engineered with a knockout of the fucosyltransferase 8 gene (FUT8). The absence of FUT8 results in a fucose-deficient antibody, significantly enhancing its Antibody-Dependent Cellular Cytotoxicity (ADCC) capabilities. This product is utilized effectively in combination with Capecitabine and Oxaliplatin for research into gastric (G) and gastroesophageal junction (GEJ) cancers.

Cat. No.

AT1029

CAS No.

2539847-03-3

Ozekibart

Synonyms: INBRX-109

Ozekibart is a monoclonal antibody specifically targeting TNFRSF10B, a member of the tumor necrosis factor receptor superfamily. This antibody binds selectively to TNFRSF10B, which is implicated in the regulation of apoptosis and cellular signaling in cancer cells. Ozekibart is utilized primarily in research focused on the mechanisms of cell death and survival in oncology, offering potential insights into therapeutic strategies and cancer treatment modalities.

Cat. No.

AT1043

CAS No.

1650599-68-0

IMAB027

Synonyms: ASP1650

IMAB027 (ASP1650) is a monoclonal antibody specifically targeting CLDN6 (Claudin 6), a tight junction membrane protein. CLDN6 is aberrantly expressed in a range of human cancers, particularly in ovarian cancers. This antibody has demonstrated potent anti-tumor activity and can induce apoptosis in CLDN6-positive ovarian and testicular cancer cell lines. IMAB027 is utilized primarily in research focused on the pathological roles of CLDN6 in cancer and the therapeutic potential of targeting this protein in oncology.

Cat. No.

AT1065

CAS No.

945228-48-8

Oportuzumab

Oportuzumab is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target EpCAM (epithelial cell adhesion molecule), also known as TROP1 or CD326. This antibody is comprised of a human immunoglobulin G1 (huIgG1) heavy chain and a human kappa (huκ) light chain, exhibiting a predicted molecular weight of approximately 145 kDa. For experimental control purposes, Human IgG1 kappa, Isotype Control is recommended.

Cat. No.

AT1082

CAS No.

1370261-50-9

Anatumomab mafenatox

Synonyms: ABR-214936

Anatumomab mafenatox (ABR-214936) is a 73 kDa recombinant protein engineered to target the tumor-associated antigen 5T4, commonly expressed in various malignancies. This biologic agent is a fusion of a modified form of staphylococcal enterotoxin A (SEA) and a murine Fab fragment, designed for precise recognition and binding to the 5T4 antigen. Commonly reported adverse effects associated with Anatumomab mafenatox include fever, hypotension, pain, nausea, and drowsiness, which should be considered in therapeutic settings. This product is pivotal for research focused on the characterization and treatment of cancers expressing the 5T4 antigen.

Cat. No.

AT1084

CAS No.

2070913-84-5

PF-03732010

PF-03732010 is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting CDH3/P-cadherin. This antibody is composed of a human IgG1 type heavy chain and a human lambda (huλ) type light chain, with a predicted molecular weight of 142.7 kDa. For isotype control, Human IgG1 kappa, Isotype Control is recommended. PF-03732010 is designed for precise binding to CDH3, making it an essential tool for research focused on cellular adhesion processes and cancer biology.

Cat. No.

AT1091

CAS No.

2460539-61-9

Osemitamab

Synonyms: TST001

Osemitamab is a recombinant IgG1 monoclonal antibody specifically designed to target human claudin-18.2. This antibody is comprised of a human-Mus musculus monoclonal TST001 gamma 1-chain linked via disulfide bonds to a human-Mus musculus monoclonal TST001 kappa-chain, forming a dimeric structure. When used in conjunction with Capecitabine and Oxaliplatin, Osemitamab serves as a potent investigational tool for the study of gastric (G) and gastroesophageal junction (GEJ) cancers. This specificity and application make it a valuable asset for targeted cancer therapy research.

Cat. No.

AT1092

Anti-CEACAM7 Antibody (P3-7B)

Anti-CEACAM7 Antibody (P3-7B) is a chimeric mouse monoclonal antibody of the IgG1, κ subclass, specifically designed to target human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 (CEACAM7). This antibody has been developed for high specificity and affinity in recognizing the CEACAM7 antigen, making it ideal for detailed studies in cancer biology and immunology. For accurate experimental control, it is recommended to use Mouse IgG1 kappa, Isotype Control as the isotype control.

Cat. No.

AT1109

CAS No.

2779564-38-2

Opugotamig

Opugotamig is a chimeric antibody designed with a half-immunoglobulin G1 kappa (half-IG G1 -κ) framework and incorporates a single-chain variable fragment (scFv -κ-heavy) linked to the human IgG CH2 and CH3 domains. It specifically targets the folate receptor alpha (FOLR1), making it suitable for research into cellular processes mediated by this receptor, including studies on targeted drug delivery and cancer cell biology.

Cat. No.

AT1114

CAS No.

1783801-93-3

CM-24

CM-24 is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting CEACAM1/CD66a. This antibody has a predicted molecular weight of 145 kDa. For isotype control purposes, Human IgG1 kappa, Isotype Control is recommended. CM-24 is designed for use in various immunological assays to study the function and role of CEACAM1/CD66a in biological processes.

Cat. No.

AT1129

CAS No.

3008247-27-3

Ubletamig

Ubletamig is a human IgG4 κ monoclonal antibody targeting MUC16. For experimental control purposes, it is recommended to use Human IgG4 kappa as an Isotype Control.

Cat. No.

AT1134

Anti-Integrin a11/ITAG11 Antibody

Cat. No.

AT1146

Anti-CDH17/Cadherin-17 Antibody (PTA001_A4)

Synonyms: PTA001_A4

The Anti-CDH17/Cadherin-17 Antibody (PTA001_A4) is a humanized monoclonal antibody, expressed in Chinese Hamster Ovary (CHO) cells, specifically designed to target CDH17, also known as Cadherin-17. This antibody is composed of an IgG1 heavy chain and a human kappa (huκ) light chain, with a molecular weight of approximately 149.12 kDa. For experimental control purposes, the appropriate isotype control is Human IgG1 kappa. This product is essential for research focusing on the role of Cadherin-17 in cellular adhesion processes and its implications in gastrointestinal tract diseases and cancers.