Catalog No.
Product Name
Application
Product Information
Citations
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Lipoxygenase
13(S)-Hydroxy-9,11,13-octadecatrienoic acid (13(S)-HPOTrE(γ) is an endogenously formed monohydroxy polyunsaturated fatty acid that serves as a substrate for soybean lipoxygenase-1 (LO-1) involved in the metabolism of γ-linolenic acid. It exhibits inhibitory effects on soybean LO-1 activity at concentrations exceeding 100 μM, and is also a precursor for the synthesis of all four isomers of 6,13-DiHOTrE. This compound is valuable for research focusing on lipoxygenase activity and the biochemical pathways involving PUFA metabolism. -
5-LOX Inhibitor
1-Naphthyl 3,5-dinitrobenzoate is a selective inhibitor of 5-lipoxygenase (5-LOX), demonstrating potent activity with an IC50 of 1.04 µM for 5-LOX and 3.6 µM for mPGES-1. This compound exhibits strong anti-inflammatory properties, evidenced by its IC50 value of 8.6 μM in human whole blood assays. It is a valuable tool for investigating the mechanisms of inflammation and exploring therapeutic strategies targeting leukotriene synthesis. -
Lipoxygenase Inhibitor
(-)-Dihydroguaiaretic acid is a potent lipoxygenase inhibitor that exhibits significant antioxidant properties. It effectively inhibits the oxidation of unsaturated fatty acids and scavenges free radicals, contributing to its protective effects. Additionally, this compound demonstrates anticancer activity with an IC50 value of 7.49 μM in A549 human lung adenocarcinoma cells, making it a valuable tool for cancer research and oxidative stress studies. -
Lipoxygenase Inhibitor
15(S)-HETRE is a lipoxygenase inhibitor, specifically targeting 5-lipoxygenase (5-LO) derived from dihomo-γ-linolenic acid through 15-lipoxygenation. It demonstrates significant inhibitory activity in human polymorphonuclear leukocytes (PMNL) with an IC50 of 4.6 μM. Additionally, in rat basophilic leukemia (RBL) cells, 15(S)-HETRE effectively inhibits 5-LO, albeit with approximately one-twentieth the potency compared to 15(S)-HpETE. This compound is utilized in research applications focused on inflammatory processes and leukotriene synthesis. -
Lipoxygenase Inhibitor
Ro 3-1314 is a potent lipoxygenase inhibitor, specifically targeting the metabolism of linoleic acid. This compound demonstrates significant biological activity by stimulating antigen-induced contraction in guinea-pig tracheal spirals and promoting the immunological release of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea-pig lung fragments. Ro 3-1314 is valuable for research applications focused on inflammation and respiratory responses. -
Arachidonic Acid 5-Lipoxygenase Inhibitor
BW B70C is a potent and selective inhibitor of arachidonic acid 5-lipoxygenase, demonstrating oral bioactivity. It effectively inhibits both acute and allergic bronchoconstriction, as well as late-phase eosinophil accumulation following allergen exposure in guinea pigs. BW B70C prevents the synthesis of leukotriene C4 and modulates leukocyte migration to the airway lumen, along with reducing albumin microvascular leakage. This compound holds promise for research into anti-asthmatic agents and related inflammatory conditions. -
5-LOX Inhibitor
5-LOX-IN-1 is a potent inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. This compound is essential for studying inflammatory pathways and the role of 5-LOX in various inflammatory diseases. Its inhibition of 5-LOX provides a valuable tool for research into therapeutic strategies targeting inflammation. -
Lipoxygenase Inhibitor
3-Chloroiminodibenzyl is a potent dual inhibitor of secreted human lipoxygenase (sHE) and 5-lipoxygenase (5-LOX). It exhibits inhibitory activity with IC50 values of 140 μM and 6.5 μM, respectively. This compound is utilized in research applications focusing on lipid signaling and inflammation pathways, making it valuable for studies related to inflammatory diseases and related therapeutic developments. -
Lipoxygenase Inhibitor
(±)15-HEDE is a racemic mixture comprised of the monohydroxy fatty acids 15(R)-HEDE and 15(S)-HEDE, derived from eicosadienoic acid within macrophages. This compound acts as a selective inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 35 μM. 15-HEDE is utilized in research to investigate lipoxygenase pathways and their implications in inflammatory processes. Its inhibitory effects on 5-LO make it a valuable tool for studying the modulation of leukotriene biosynthesis and related biological activities. -
5-Lipoxygenase Inhibitor
ZD 2138 is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of leukotrienes, which play a significant role in inflammation and bronchoconstriction. This compound has demonstrated potential in alleviating aspirin-induced bronchoconstriction, making it a valuable tool in asthma research and studies focused on respiratory disorders. Its application in modulating inflammatory pathways positions ZD 2138 as an important reagent for investigating therapeutic strategies in related pulmonary conditions. -
Lipoxygenase Inhibitor
Enazadrem is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the inflammatory response. It exhibits significant anti-inflammatory activity, making it a valuable tool for research in fields such as immunology and cancer therapy. This compound aids in the elucidation of pathways related to leukotriene synthesis and may contribute to the development of therapeutic strategies targeting inflammation-related diseases. -
5-Lipoxygenase Inhibitor
TA-270 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes, which are key mediators in inflammatory processes. This quinolinone derivative is primarily utilized in asthma research to elucidate the role of leukotrienes in airway inflammation and hyperreactivity. Its selective inhibition of 5-lipoxygenase provides a valuable tool for investigating therapeutic strategies aimed at respiratory conditions. -
5-lipoxygenase inhibitor
HZ52 is a reversible inhibitor of 5-lipoxygenase, effectively blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes. This compound is valuable for research applications aimed at understanding inflammatory responses and the role of leukotrienes in various diseases. HZ52 may be useful in exploring therapeutic strategies for conditions such as asthma, arthritis, and other inflammatory disorders. -
5-Lipoxygenase Inhibitor
AHR-5333 is a selective inhibitor of 5-lipoxygenase, primarily targeting human blood neutrophils. This compound demonstrates significant and prolonged activity in in vivo models of immediate hypersensitivity, specifically in rats and guinea pigs. AHR-5333 is applicable in research related to inflammatory responses and may provide insights into therapeutic strategies for conditions associated with leukotriene overproduction. -
5-Lipoxygenase Inhibitor
5-LOX-IN-3 is a potent inhibitor of 5-Lipoxygenase, exhibiting an IC50 of less than 1 μM. This compound is valuable for research focused on inflammatory diseases, cancer, stroke, and Alzheimer’s disease, allowing for the exploration of its therapeutic potential in modulating inflammatory pathways. 5-LOX-IN-3 serves as a useful tool in the study of these critical health conditions. -
5-LOX Inhibitor
Tagorizine is a potent inhibitor of 5-lipoxygenase (5-LOX), a key enzyme in the leukotriene biosynthesis pathway. This reagent is valuable for studying vascular biology, particularly in examining cerebral and peripheral blood vessel dilation. Its inhibitory properties make it useful for research into inflammatory responses and related vascular conditions. -
5-LOX Inhibitor
5,6-Dehydroarachidonic acid is an inhibitor of 5-lipoxygenase (5-LOX), targeting the enzymatic pathway responsible for leukotriene biosynthesis. This compound effectively reduces leukotriene production, making it valuable for studies related to inflammation and related pathologies. It has been noted that 5,6-Dehydroarachidonic acid does not influence vascular cell proliferation, highlighting its specificity in research applications. -
5-lipoxygenase Inhibitor
WY-50295 is a selective inhibitor of 5-lipoxygenase, impacting the biosynthesis of leukotrienes. It demonstrates an IC50 of 40 μM in inhibiting LTB4 formation in rat whole blood leukocytes, with an oral ED50 of 18 mg/kg. This compound is valuable for studying asthma and other conditions associated with leukotriene signaling. -
15-Lipoxygenase Inhibitor
Caffeoylcalleryanin is a potent inhibitor of 15-lipoxygenase, exhibiting an IC50 value of 1.59 µM. This compound demonstrates a strong capability to modulate lipid metabolism by inhibiting the action of lipoxygenases, crucial for the biosynthesis of lipid mediators. Caffeoylcalleryanin is suitable for research applications focusing on inflammatory pathways and the study of lipid-related processes. Additionally, it shows no cytotoxic effects, making it a valuable tool for cellular and molecular biology studies. -
5-Lipoxygenase Inhibitor
AHR-5333 (mandelate) is a selective inhibitor of 5-lipoxygenase, targeting human blood neutrophils. This compound demonstrates robust and sustained activity in vivo, particularly in models of immediate hypersensitivity in rats and guinea pigs. AHR-5333 (mandelate) is valuable for research applications exploring inflammatory responses and allergic reactions. -
Leukotriene/5-lipoxygenase Inhibitor
L-656224 is a potent and selective inhibitor of leukotriene biosynthesis, acting primarily on 5-lipoxygenase. Demonstrating strong inhibitory activity in both intact rat and human leukocytes as well as CXBG mastocytoma cells (IC50 values ranging from 18 to 240 nM), it significantly impacts human and porcine leukocyte 5-lipoxygenase with an IC50 of 4 x 10^-7 M. This compound shows potential for research applications in asthma and the development of peripheral analgesic agents. -
5-lipoxygenase Inhibitor
CJ-13,610 hydrochloride is a potent and orally active nonredox-type inhibitor of 5-lipoxygenase, exhibiting an IC50 value of 0.07 μM. By competing with activating lipid hydroperoxides at a key regulatory binding site, it effectively prevents 5-lipoxygenase catalysis. This reagent is valuable for research into conditions associated with increased 5-lipoxygenase activity, including inflammatory disorders, allergic asthma, cancer, and atherosclerosis. -
5-LOX/MAO Inhibitor
5-LOX/MAOs-IN-1 is a dual inhibitor of 5-lipoxygenase (5-LOX) and monoamine oxidases (MAOs), exhibiting potent antioxidant properties through free radical scavenging. This compound demonstrates neuroprotective effects in cell models subjected to oxidative stress and promotes a supportive microenvironment for neurogenesis in adult mouse neural stem cells. 5-LOX/MAOs-IN-1 is suitable for research focused on neurodegenerative diseases and mechanisms of neuroprotection. -
5-lipoxygenase Inhibitor
Fluindione is a potent inhibitor of 5-lipoxygenase, exhibiting an IC50 of 15 μM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research in the study of inflammatory pathways and related diseases. Its inhibition of leukotriene synthesis further supports its application in exploring potential therapeutic interventions for conditions characterized by excessive inflammation. -
Lipoxygenase Inhibitor
MLS000536924 is a selective inhibitor of human epithelial 15-lipoxygenase-2, exhibiting competitive inhibition with over 50-fold selectivity. This compound plays a crucial role in exploring the biological functions of h15-LOX-2 and is particularly relevant in research areas including atherosclerosis, cystic fibrosis, and ferroptosis. The binding mechanism of MLS000536924 demonstrates significant restriction of protein mobility, confirming its enhanced biological efficacy compared to other lipoxygenase inhibitors. -
Lipoxygenase
AA863 is a selective inhibitor of 5-lipoxygenase, which plays a crucial role in the metabolism of arachidonic acid and the production of leukotrienes. This compound demonstrates significant dose-dependent inhibition of human glioma cell proliferation, with an IC50 value of 9.0 micromolar in monolayer cultures. AA863 is a valuable tool for researchers investigating glioma biology and the therapeutic potential of targeting lipoxygenase pathways. -
Lipoxygenase Substrate
1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol serves as a substrate for lipoxygenase enzymes, playing a critical role in the formation of bioactive lipids. This compound is involved in various biological processes, including inflammation and cellular signaling pathways. Its application in research includes studies on lipid metabolism and the role of lipoxygenases in disease models. -
12/15-LOX Inhibitor
MLS000099089 is a potent inhibitor of 12/15-lipoxygenase (12/15-LOX), demonstrating IC50 values of 3.4 μM for human and 10 μM for murine 12/15-LOX. This compound exhibits notable selectivity for 12/15-LOX over 5-LOX and COX-2, making it a valuable tool for research. MLS000099089 is applicable in studies related to stroke and other pathophysiological conditions involving lipoxygenase pathways. -
5-lipoxygenase Inhibitor
Enazadrem phosphate is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes. By inhibiting this target, Enazadrem phosphate exhibits significant anti-inflammatory activity, making it a valuable tool for research into inflammatory diseases and related pathways. Its application in preclinical studies may further elucidate the role of leukotrienes in various inflammatory conditions. -
5-lipoxygenase Inhibitor
Bay-y-1015 is an orally active quinoline-based inhibitor of 5-lipoxygenase, effectively blocking the synthesis of leukotrienes such as LTB4 and LTC4. This compound is valuable for research focused on inflammatory diseases, providing insights into mechanisms underlying inflammation and potential therapeutic approaches. -
Antioxidant/Lipoxygenase Inhibitor
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone is a potent antioxidant and lipoxygenase inhibitor derived from Parinari hypochrysea, a member of the Chrysobalanaceae family. This compound effectively mitigates oxidative stress and reduces lipoxygenase activity, making it valuable in studies related to inflammation and oxidative damage. Its biological activities support its application in pharmacological research focused on developing anti-inflammatory therapeutics. -
Lipoxygenase Inhibitor
ICI 198615 is a potent inhibitor of lipoxygenase, targeting the enzymes involved in the metabolism of eicosanoids. By inhibiting lipoxygenase activity, ICI 198615 effectively attenuates the early phase of bronchoconstriction induced by endothelin-1 (ET-1). This compound is useful for research focused on respiratory disorders and inflammatory responses related to eicosanoid signaling pathways. -
Lipoxygenase Inhibitor
tHGA is a potent lipoxygenase inhibitor with demonstrated anti-inflammatory properties. It effectively inhibits soybean 15-lipoxygenase (15-LOX) with an IC50 of 0.42 μM and exhibits concentration-dependent inhibition of 5-lipoxygenase (5-LOX) product synthesis, particularly cysteine leukotriene LTC(4), with an IC50 of 1.80 μM. Notably, tHGA shows no cytotoxicity and operates through a dual inhibition mechanism targeting both LOX and COX-2, with enhanced selectivity for 5-LOX and COX-2 (IC50 of 0.40 μM). This compound is valuable for research applications focused on inflammatory processes and lipoxygenase-related signaling pathways. -
5-LOX Antagonist
ALR-38 is a selective 5-lipoxygenase (5-LOX) antagonist with an IC50 value of 1.1 μM, demonstrating significant anti-inflammatory properties. This compound effectively lowers reactive oxygen species (ROS) levels in neutrophils, making it valuable for research into inflammation and related pathological conditions. ALR-38 serves as a potential tool for studying the role of 5-LOX in inflammatory responses and developing therapeutic strategies. -
LOX Inhibitor
CCT365623 is a selective lipoxygenase (LOX) inhibitor with an IC50 of 0.9 μM. It demonstrates significant anti-metastatic activity in vivo, making it a valuable tool for cancer research. This compound can be utilized to investigate the role of LOX in tumor progression and to explore potential therapeutic approaches targeting metastasis. -
Lipoxygenase Inhibitor
Cgp 8065 is a selective inhibitor of 5-lipoxygenase, a key enzyme involved in the metabolism of arachidonic acid to leukotrienes. By inhibiting this enzyme, Cgp 8065 exerts significant anti-inflammatory effects, making it a valuable tool for studies related to asthma, allergic responses, and other inflammatory diseases. This reagent is suitable for exploring the biochemical pathways associated with lipoxygenase activity and for evaluating potential therapeutic targets in related conditions. -
5-Lipoxygenase Inhibitor
L 670630 is a potent, orally active inhibitor of 5-lipoxygenase, exhibiting an IC50 of 23 nM. This compound effectively modulates the biosynthesis of leukotrienes, which are involved in inflammatory responses. L 670630 is utilized in research applications focused on chronic inflammatory diseases and asthma, providing a valuable tool for studying the role of leukotrienes in these conditions. -
Lipoxygenase
L-691831 is a potent ligand for the 5-lipoxygenase activating protein (FLAP). It is primarily utilized in binding assays to explore FLAP-related activities, particularly in leukocyte membranes. This compound enables the measurement of FLAP affinity for leukotriene synthesis inhibitors, providing insights into the mechanisms of leukotriene production and potential therapeutic targets in inflammatory conditions. -
5-Lipoxygenase Inhibitor
Sigmoidin B is a selective inhibitor of 5-lipoxygenase, targeting the leukotriene synthesis pathway. This prenylated flavanone exhibits significant antioxidant activity by effectively scavenging DPPH radicals. Additionally, Sigmoidin B demonstrates antigenotoxic effects, notably inhibiting genotoxicity induced by Aflatoxin B1 with an IC50 of 18.7 μg/mL, and possesses anti-inflammatory properties. Its diverse biological activities make it a valuable reagent for research in inflammation and oxidative stress-related studies. -
5-lipoxygenase Inhibitor
15(S)-HEDE is a potent inhibitor of 5-lipoxygenase, demonstrating an IC50 value of 26 μM. This compound functions by inhibiting the enzymatic activity associated with leukotriene synthesis, making it a valuable tool for studying inflammatory diseases. Researchers can utilize 15(S)-HEDE to explore pathways related to inflammation and potential therapeutic interventions. -
5-lipoxygenase Inhibitor
SC-45662 is a selective inhibitor of 5-lipoxygenase, a key enzyme involved in leukotriene biosynthesis. This compound effectively suppresses the activation of monocytes in response to phytohemagglutinin (PHA) and reduces superoxide production in neutrophils, highlighting its potential impact on inflammation. SC-45662 has also demonstrated the ability to ameliorate early alterations in lung mechanics and alleviate pulmonary hypertension in sheep models of compromised lung function. Its applications include research into immune system disorders, respiratory diseases, and related pathological conditions. -
Lipoxygenase Inhibitor
Myxochelin A is a potent lipoxygenase inhibitor derived from the microbial metabolite of A. disciformis. It demonstrates significant antibacterial activity against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, while exhibiting no activity against Gram-negative bacteria or fungi in agar diffusion assays. Additionally, Myxochelin A inhibits 5-lipoxygenase (5-LO) with an IC50 of 1.9 μM for recombinant human enzymes and shows cytotoxic effects on 26-L5 colon cancer cells at a concentration of 3 μg/mL, making it a valuable compound for research in inflammation and cancer biology. -
15-Lipoxygenase-1 Inhibitor
BLX-2477 is a potent and selective inhibitor of 15-lipoxygenase-1 (15-LOX-1), demonstrating an IC50 value of 99 nM. This compound effectively inhibits the production of inflammatory lipid mediators, including 15-hydroxy-eicosatetraenoic acid (15-HETE). BLX-2477 is suitable for research applications in the fields of inflammation and immunology, facilitating the study of related biological processes and potential therapeutic interventions. -
5-Lipoxygenase Inhibitor
L 691816 is a potent and selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of leukotrienes. This compound exhibits significant anti-inflammatory activity, making it relevant for research applications focused on allergies and asthma. Its oral bioavailability supports various in vivo studies aimed at elucidating the role of leukotrienes in inflammatory conditions. -
5-LOX Inhibitor
(1Z)-Atractylodinol is identified as a weak inhibitor of 5-lipoxygenase (5-LOX), demonstrating an IC50 value of 17.8 μM. This compound is valuable for research focused on inflammatory diseases, providing insights into the mechanisms of inflammation and potential therapeutic targets. Its role in modulating leukotriene synthesis makes it a relevant tool for those investigating 5-LOX-related pathways in various biological contexts. -
h15-LOX-2 Inhibitor
h15-LOX-2 inhibitor 1 is a selective inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), demonstrating an IC50 value of 0.34 μM. This compound effectively modulates lipid metabolism and inflammatory processes, making it a valuable tool for research into the role of h15-LOX-2 in various biological systems. It is suitable for studies related to inflammation, cancer, and cardiovascular disease. -
Lipoxygenase Inhibitor
Setileuton tosylate is a potent inhibitor of 5-lipoxygenase, effectively blocking the oxidation of arachidonic acid by recombinant human 5-LO. This compound demonstrates significant activity in reducing the production of leukotriene B4 (LTB4) in calcium ionophore-stimulated human whole blood, with IC50 values of 3.9 nM and 52 nM, respectively. Setileuton tosylate is valuable in research applications related to inflammatory pathways and leukotriene synthesis. -
Lipoxygenase Inhibitor
FLM-5011 is a selective lipoxygenase inhibitor that demonstrates protective effects against myocardial ischemia injury while exhibiting anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and cardiovascular diseases, including myocarditis, by modulating lipoxygenase pathways. -
5-lipoxygenase Inhibitor
CBS-1114 hydrochloride is a potent 5-lipoxygenase inhibitor that plays a critical role in modulating inflammatory pathways. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research focused on inflammation and related disorders. Its ability to selectively inhibit 5-lipoxygenase positions it as an important reagent for studies investigating the underlying mechanisms of inflammation and potential therapeutic strategies. -
Lipoxygenase Inhibitor
RG 6866 is a potent inhibitor of 5-lipoxygenase (5-LOX), aimed at modulating inflammatory responses in cardiac tissues. This compound demonstrates the capacity to alleviate coronary artery constriction and mitigate negative inotropic effects during cardiac inflammatory states. RG 6866 effectively blocks antigen-induced reductions in coronary flow, making it a valuable tool for research in cardiovascular biology and inflammation studies.
