Catalog No.
Product Name
Application
Product Information
Citations
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h15-LOX-2 Inhibitor
h15-LOX-2 inhibitor 3 is a selective inhibitor of the enzyme h15-LOX, demonstrating an IC50 of 25 μM and a Ki of 15.1 μM. This compound is utilized in research applications focused on investigating the role of h15-LOX in inflammatory processes and related diseases. Its inhibitory activity provides valuable insights into therapeutic strategies for modulating lipid metabolism and inflammatory signaling pathways. -
5-lipoxygenase Inhibitor
A-78773 is a potent inhibitor of 5-lipoxygenase, demonstrating significant inhibition of leukotriene B4 (LTB4) production in human whole blood and neutrophils, with IC50 values of 85 nM and 20 nM, respectively. This compound is valuable for research into inflammation-related diseases, providing insights into leukotriene-mediated pathways and potential therapeutic interventions. -
5-LOX Inhibitor
Zileuton sulfoxide is a selective inhibitor of lipoxygenase 5-LOX, targeting the lipoxygenase pathway involved in inflammatory responses. It exhibits significant anti-asthmatic properties, making it valuable in studying respiratory conditions and related inflammatory diseases. This compound is useful for research applications focusing on the modulation of leukotriene biosynthesis and understanding the role of 5-LOX in various pathological processes. -
5-lipoxygenase Inhibitor
L-651392 is a selective inhibitor of 5-lipoxygenase, effectively blocking the synthesis of leukotrienes. This compound demonstrates significant anti-inflammatory properties, particularly in the context of Escherichia coli pyelonephritis, by hindering the migration of inflammatory cells to the infection site and safeguarding renal tubules from inflammation-induced damage. L-651392 serves as a valuable tool for research focused on inflammatory processes and renal pathologies. -
5-lipoxygenase Inhibitor
A-79175 is a potent inhibitor of 5-lipoxygenase, a key enzyme involved in the synthesis of leukotrienes. By suppressing leukotriene formation, A-79175 demonstrates significant potential for the investigation of various allergic and inflammatory conditions, such as asthma, allergic rhinitis, rheumatoid arthritis, and inflammatory bowel disease. Its mechanism of action makes it a valuable tool for research in the field of immunology and inflammation. -
Lipoxygenase
(E)-L-652343 is a selective inhibitor of lipoxygenase pathways, demonstrating potent activity against cyclooxygenase and 5-lipoxygenase. This compound effectively reduces the synthesis of inflammatory products associated with these pathways in vivo. Additionally, (E)-L-652343 displays high sensitivity and specificity for detecting geometric isomers in both canine and human plasma, with a notable difference in the elimination rates of its E and Z isomers. Its selective metabolism further supports its utility in biochemical research and therapeutic applications targeting inflammatory disorders. -
Lipoxygenase Inhibitor
LP117 is a potent inhibitor of 5-Lipoxygenase (5-LO), demonstrating an IC50 value of 1.1 μM. This compound impedes the synthesis of 5-LO products, thereby regulating inflammatory pathways. LP117 is applicable in research focused on inflammatory diseases, asthma, and other conditions influenced by leukotriene metabolism. Its selectivity and efficacy make it a valuable tool for studying lipoxygenase-related mechanisms in biological systems. -
Lipoxygenase Inhibitor
Lagunamycin is a selective inhibitor of 5-lipoxygenase, derived from the culture medium of Streptomyces sp. AA0310. It demonstrates significant inhibitory activity with an IC50 value of 6.08 μM against rat 5-lipoxygenase, effectively preventing leukotriene biosynthesis. Notably, lagunamycin achieves this inhibition without inducing lipid peroxidation, making it a valuable tool for studying inflammatory processes and potential therapeutic applications in conditions mediated by 5-lipoxygenase activity. -
Lipoxygenase Inhibitor
BI-L-357 is a lipoxygenase inhibitor that serves as a precursor derived from BI-L-226. It enhances oral bioavailability and effectively inhibits 5-lipoxygenase-mediated leukotriene production, making it a valuable tool for research focused on inflammatory responses and related signaling pathways. This compound's ability to modulate leukotriene levels offers significant potential in studies investigating asthma, allergic reactions, and other inflammatory disorders. -
5-lipoxygenase Inhibitor
Fenleuton is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the synthesis of leukotrienes. By blocking this pathway, Fenleuton demonstrates significant potential for the study of leukotriene-mediated inflammatory diseases, particularly in exploring its role in asthma, rheumatoid arthritis, and other inflammatory conditions. This reagent is valuable for researchers investigating therapeutic strategies targeting leukotriene-related pathways. -
5-lipoxygenase Inhibitor
SB 210661 is a potent and selective inhibitor of 5-lipoxygenase, a key enzyme involved in the biosynthesis of leukotrienes. By inhibiting this enzyme, SB 210661 modulates inflammatory responses and has potential applications in the study of asthma, arthritis, and other inflammatory diseases. This compound serves as a valuable tool for researchers investigating the role of leukotrienes in various biological processes. -
Lipoxygenase
Leukotriene A 3 methyl ester is a lipoxygenase metabolite derived from 5,8,11-eicosatrienoic acid through the 5-lipoxygenase (5-LO) pathway. This compound exhibits significant biological activity, particularly in the modulation of inflammatory responses and immune cell signaling. It is commonly used in research applications focused on leukotriene biosynthesis and related inflammatory processes. -
Lipoxygenase Inhibitor
CMI977 is a potent inhibitor of 5-Lipoxygenase (5-LO), an enzyme involved in the biosynthesis of leukotrienes. By effectively inhibiting 5-LO, CMI977 demonstrates significant anti-inflammatory properties, making it a valuable tool for research in inflammation and related diseases. Its application extends to studies focused on the modulation of leukotriene-mediated pathways, providing insights into targeted therapies for various inflammatory conditions. -
5-Lipoxygenese/PAF Receptor Antagonist
CMI-392 is a dual inhibitor of 5-lipoxygenase and a platelet-activating factor (PAF) receptor antagonist, exhibiting IC50 values of 100 nM and 10 nM, respectively. This compound demonstrates significant anti-inflammatory activities by modulating leukotriene synthesis and PAF signaling pathways. CMI-392 is valuable for research applications focused on inflammatory diseases and related therapeutic targets. -
Lipoxygenase Inhibitor
AZD 4407 is a potent inhibitor of 5-lipoxygenase, an enzyme involved in the biosynthesis of leukotrienes. This compound exhibits significant anti-inflammatory properties, making it a valuable tool for research in areas such as asthma, arthritis, and other inflammatory diseases. AZD 4407 is utilized to study the modulation of leukotriene-mediated pathways in various biological contexts. -
LOX-1 Inhibitor
BI-0115 is a selective LOX-1 inhibitor with an IC50 of 5.4 μM, effectively blocking the cellular uptake of oxidized low-density lipoprotein (oxLDL). This compound disrupts receptor activity through the formation of dimers within the homodimeric ligand binding domain. BI-0115 is valuable for research focused on atherosclerosis and cardiovascular diseases, providing insight into the modulation of lipid metabolism and inflammatory processes. -
LOX-1 Inhibitor
DKI5, or (E)-N’-benzylidenehydrazinecarbothiohydrazide, is a selective inhibitor of LOX-1, with an IC50 value of 22.5 μM. This compound demonstrates potential anti-inflammatory properties by targeting the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). DKI5 is suitable for research applications involving cardiovascular studies and the modulation of atherosclerosis-related pathways. -
LXR Degrader
GAC0003A4 is an LXR (liver X receptor) degrader that inhibits LXR transcriptional activity. It effectively promotes the degradation of LXRβ protein, thereby decreasing its biological function. This compound shows potential for research applications in advanced pancreatic cancer and other refractory malignancies, making it a valuable tool for studying LXR-related pathways in cancer biology. -
Phospholipase Inhibitor
ML-211 is a carbamate-based inhibitor targeting acyl-protein thioesterase 1 (APT1) and lysophospholipase 1 (LYPLA1), with an IC50 of 17 nM, as well as lysophospholipase 2 (LYPLA2) with an IC50 of 30 nM. Additionally, it inhibits the serine hydrolase ABHD11 at an IC50 of 10 nM while demonstrating greater than 50-fold selectivity for LYPLA in a diverse panel of 20 serine hydrolases. ML-211 is valuable for research involving lipid metabolism and signaling pathways, particularly those associated with phospholipase activity. -
CYP11B1/CYP11B2 Inhibitor
Osilodrostat phosphate is a selective inhibitor of 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2), demonstrating an IC50 of 35 nM and 0.7 nM, respectively, for human enzymes. This compound effectively inhibits the synthesis of aldosterone and corticosterone, contributing to its role in blood pressure regulation. Osilodrostat phosphate is particularly valuable for research investigating Cushing syndrome and related disorders involving dysregulated steroidogenesis. -
Chelating Agent, Mitochondrial Electron Transport Chain Inhibitor, Carboxylesterase Inhibitor
2-Thenoyltrifluoroacetone is a chelating agent that targets the mitochondrial electron transport chain, exhibiting an IC50 value of 51.5 μM. It effectively chelates various metal ions and demonstrates cytotoxicity along with anti-tumor activity. This compound holds potential for applications in the treatment of diseases linked to mitochondrial dysfunction, contributing valuable insights into related therapeutic strategies. -
Herbicide
Simeton is a methoxy-5-triazine herbicide that targets photosynthesis in plants, effectively inhibiting weed growth in various agricultural settings. Its primary application is in the control of broadleaf and grassy weeds in crops such as corn, wheat, maize, and barley. This compound plays a vital role in enhancing crop yield by minimizing competition from undesired vegetation. -
Herbicide
Epopromycin B is a herbicide that acts by inhibiting cell wall synthesis in lettuce protoplasts, demonstrating significant herbicidal activity. In addition to its agricultural applications, Epopromycin B displays cytotoxic effects in B16 melanoma cells, with an IC50 value of 0.003 µg/mL, highlighting its potential for further research in cancer biology. -
Herbicide
Chloridazon is a selective herbicide that inhibits photosynthesis by targeting the D1 protein in the photosystem II complex. It exhibits significant herbicidal activity against a broad spectrum of annual and perennial weeds. Research applications include studies on plant physiology and environmental impact assessments of herbicide use. The compound has an LD50 value of 76.6 ppm, indicating its level of genotoxicity in assays. -
Herbicide
Dithiopyr is a selective herbicide targeting major grassy weeds and small-seeded broadleaf weeds. It exerts its effects through pre-emergence or early post-emergence application, disrupting weed establishment and growth. This compound is widely utilized in agricultural research to develop effective weed management strategies. -
Herbicide
5,6-Bis(4-methoxyphenyl)-2,3-diphenylthieno[3,2-b]furan acts as a selective herbicide targeting various plant species. This compound demonstrates significant herbicidal activity by disrupting key biological pathways involved in plant growth and development. It is applicable in agricultural research and studies focused on weed management strategies. -
Herbicide
Napropamide-M is a selective herbicide that targets the growth of various broadleaf and grassy weeds in winter oilseed rape and brassica vegetable crops. It functions by inhibiting cell division, ultimately disrupting plant growth. Its efficacy makes it a valuable tool for agricultural research and crop management practices. -
Herbicide
Metazosulfuron is an acetolactate synthase (ALS) inhibitor serving as an effective herbicide. It is specifically designed for the control of pondweed (Potamogeton nodosus) and effectively prevents its regrowth in transplanted rice systems. Additionally, Metazosulfuron contributes to enhanced yields of rough rice grain, supporting agricultural productivity. -
Corn Herbicide
Tolpyralate is a selective post-emergence herbicide that functions primarily by inhibiting the enzyme 4-hydroxyphenylpyruvate dioxygenase (4-HPPD). This compound demonstrates potent herbicidal activity against a range of weed species, including the glyphosate-resistant Amaranthus tuberculatus. Tolpyralate is essential for agricultural research and weed management strategies in corn cultivation. -
Herbicide
Cis-2-Amino-1-hydroxycyclobutane-1-acetic acid is a herbicidal antimetabolite that targets amino acid biosynthesis pathways, leading to chlorosis in Arabidopsis thaliana. This compound acts by interfering with the synthesis of essential metabolites, specifically causing reversible symptoms associated with L-cysteine or L-methionine depletion. It is valuable in research applications focused on understanding herbicide mechanisms and plant response to metabolic stress. -
Herbicide
Butroxydim is an acetyl-coenzyme A carboxylase (ACCase) inhibitor utilized as a selective herbicide. This compound effectively targets and controls herbicide-resistant populations of Hordeum leporinum, demonstrating significant efficacy against strains resistant to other ACCase inhibitors. It is therefore valuable for researchers studying herbicide resistance mechanisms and developing effective weed management strategies. -
Herbicide
Carfentrazone-ethyl is a selective post-emergence herbicide that acts as a protoporphyrinogen oxidase (Protox) inhibitor, exhibiting an IC50 value of 18 nM against soybean Protox. This compound effectively disrupts the biosynthesis of chlorophyll and heme, leading to the rapid death of susceptible weeds, such as ivy-leaved morning glory and velvetleaf. Its primary applications include the control of broadleaf weeds in various agricultural settings, making it a valuable tool in herbicide research and development. -
Herbicide
Atraton is a 1,3,5-triazine herbicide that exerts its activity through selective inhibition of photosynthetic processes in target plants. This compound is noted for its photodegradability, undergoing degradation when activated by the photosensitizer acetone. Atraton is primarily utilized in agricultural research to study the effects of herbicide application and its environmental fate. -
Herbicide
Buminafos is an organophosphate herbicide that targets key enzymes involved in weed growth regulation. It exhibits broad-spectrum activity against various weed species, making it valuable for enhancing agricultural productivity. This reagent is primarily used for research applications related to herbicide efficacy and the mechanisms of herbicide resistance in crops. -
Herbicide
Flupropanate is a selective herbicide that functions as a plant growth inhibitor by disrupting radicle growth and lipid biosynthesis in susceptible plants. It effectively controls Stipa weeds, including Nassella neesiana and N. trichotoma, while reducing the prevalence of the invasive species Eragrostis curvula. Flupropanate shows sensitivity to gramineous plants like ryegrass but exhibits good tolerance in species such as plantain, chicory, and some legumes. Research indicates that in Mediterranean climates, Flupropanate has minimal non-target impact on native plant communities and endangered species, demonstrating its ecological safety. -
Herbicide
Sulfosate is a post-emergence, non-selective herbicide that functions by inhibiting the synthesis of essential amino acids in plants. It effectively controls a broad spectrum of weeds through translocation, making it useful in various agricultural applications. Sulfosate is particularly valuable in the management of challenging weed populations, facilitating improved crop yield and quality. -
Herbicide
Defenuron is a selective herbicide that inhibits the growth of undesirable grasses and broad-leaved plants in various agricultural crops. Its primary mechanism targets specific biochemical pathways, effectively minimizing competition for nutrients and sunlight. Defenuron is utilized in research to study herbicidal activity and crop management strategies, contributing to the development of sustainable agricultural practices. -
Herbicide
Monisouron (SSH-41) is a selective herbicide targeting post-emergence control of a range of broad-leaved and grass weeds while preserving the integrity of crops such as barley, pea, and maize. This compound demonstrates significant herbicidal activity, making it a valuable tool for research focused on weed management strategies and agricultural applications. Its selectivity profile contributes to effective weed control in diverse crop systems. -
HMG-CoA reductase Inhibitor
Atorvastatin (lysine) is a potent inhibitor of HMG-CoA reductase, a key enzyme in the cholesterol biosynthesis pathway. This compound is primarily utilized in research focused on hypercholesterolemia and mixed hyperlipidemia, enabling studies on lipid regulation and cardiovascular health. Its ability to modulate cholesterol levels makes it valuable for investigating therapeutic approaches for dyslipidemia-related conditions. -
HMG-CoA Reductase Inhibitor
BMS-180431 is a potent inhibitor of HMG-CoA reductase, with an IC50 value of 43 nM. This compound effectively reduces cholesterol biosynthesis, making it relevant for research in lipid metabolism and cardiovascular disease. It is applicable in studies exploring hyperlipidemia, atherosclerosis, and related metabolic disorders. -
HMG-CoA Reductase (HMGCR) Inhibitor
Lovastatin hydroxy acid sodium is a potent inhibitor of HMG-CoA reductase (HMGCR), exhibiting a Ki of 0.6 nM. By effectively blocking the enzymatic action of HMGCR, this compound plays a critical role in cholesterol biosynthesis regulation. It is widely utilized in research to explore lipid metabolism, cardiovascular diseases, and therapeutic interventions for dyslipidemia. -
HMG-CoA Inhibitor
Pravastatin lactone is a potent HMG-CoA reductase inhibitor that functions as a metabolite of pravastatin. It effectively decreases blood cholesterol levels by inhibiting the synthesis of cholesterol in the liver. This compound is widely used in research related to lipid metabolism, cardiovascular diseases, and the development of cholesterol-lowering therapies. -
HMG-CoA Reductase (HMGCR) Inhibitor
β-Amyrin palmitate is an HMG-CoA reductase (HMGCR) inhibitor that plays a crucial role in lipid metabolism. This compound exhibits biological activity that can aid in the management of diabetes mellitus, making it a valuable reagent for research in metabolic disorders. Its ability to modulate cholesterol biosynthesis may also offer insights into cardiovascular health and related conditions. -
HMG-CoA Inhibitor
Bemfivastatin hemicalcium is an orally active inhibitor of HMG-CoA reductase (HMGCR), targeting cholesterol biosynthesis. This compound effectively promotes the liver's ability to extract lipids, leading to a significant reduction in blood lipid levels. Bemfivastatin hemicalcium is applicable in research on metabolic disorders, particularly in studying hypercholesterolemia and related conditions. -
HMG-CoA Inhibitor
Lovastatin acid is a potent competitive inhibitor of HMG-CoA reductase, with an inhibition constant (Ki) of 0.6 nM. As an active metabolite of Lovastatin, it effectively interferes with cholesterol synthesis by inhibiting the conversion of HMG-CoA to mevalonate. This compound is particularly valuable for research into hypercholesterolemia and related metabolic disorders. -
HMG-CoA Reductase Inhibitor
(3S,5S)-Pitavastatin calcium is a potent HMG-CoA reductase inhibitor effective in lowering cholesterol levels. It plays a significant role in the study of cardiovascular diseases by inhibiting lipid biosynthesis and improving lipid profiles. This compound is primarily utilized in research applications focused on atherogenesis and the investigation of statin therapy mechanisms. -
HMG-CoA Reductase Inhibitor
Rosuvastatin zinc salt is a zinc-complexed form of Rosuvastatin, an HMG-CoA reductase inhibitor. This compound effectively reduces cholesterol synthesis, making it valuable in atherosclerosis research. Its mechanism of action supports studies focusing on lipid regulation and cardiovascular disease prevention. -
HMG-CoA Reductase (HMGCR)
(3S,5R)-Fluvastatin potassium is an inhibitor of HMG-CoA reductase, a key enzyme in cholesterol biosynthesis. This compound exhibits antioxidative properties, influencing the oxidation of LDL in the presence of copper ions, akin to its 3R,5S enantiomer. Investigations have indicated that (3S,5R)-Fluvastatin potassium and its metabolites may possess anti-atherosclerotic effects through their antioxidative activities. It is commonly employed in research focused on cholesterol regulation and cardiovascular disease mitigation. -
HMG-CoA Reductase (HMGCR)
Ganoderic acid SZ is a potent inhibitor of HMG-CoA reductase (HMGCR), demonstrating superior activity compared to atorvastatin. This natural compound also significantly inhibits α-glucosidase derived from yeast, with low nanomolar IC50 values. Additionally, Ganoderic acid SZ exhibits cytotoxic effects against K562 leukemia cells, with IC50 values ranging from 10 to 20 μM. These properties make Ganoderic acid SZ a valuable tool for research in cholesterol metabolism and cancer studies. -
HMG-CoA Reductase Inhibitor
BMS-180431 sodium is a potent inhibitor of HMG-CoA reductase, with an IC50 value of 43 nM. This compound plays a pivotal role in cholesterol biosynthesis, making it valuable for research focused on lipid metabolism and related cardiovascular diseases. Its inhibitory effects on HMG-CoA reductase provide a useful tool for studying cholesterol-lowering interventions and the underlying mechanisms of dyslipidemia.
