Dynamin | Adooq Bioscience

Cat. No.: A12726

CAS No.: 304448-55-3

Dynasore

Dynasore is a non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity

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5 mg

$40.00

10 mg

$50.00

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Cat. No.: A14316

CAS No.: 338967-87-6

Mdivi-1

Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 uM.

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5 mg

$25.00

10 mg

$45.00

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Cat. No.: A15915

CAS No.: 1256493-34-1

Dyngo-4a

Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 uM, 1.1uM, and 2.3 uM for DynI (brain), DynI (rec), and DynII (rec), respectively.

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5 mg

$40.00

10 mg

$70.00

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Cat. No.: A14867

CAS No.: 251634-21-6

Dynamin inhibitory peptide

Dynamin Inhibitory Peptide is a peptide inhibitor of the GTPase dynamin.

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Cat. No.: A30133

CAS No.: 1128165-88-7

Dynole 34-2 is a potent inhibitor of dynamin GTPase, with IC50 values of 6.9 µM and 14.2 µM for dynamin 1 and dynamin 2, respectively. This compound exhibits antimitotic properties and induces apoptosis, characterized by cell blebbing, DNA fragmentation, and cleavage of PARP. Additionally, Dynole 34-2 effectively inhibits receptor-mediated endocytosis, making it a valuable tool for research in cellular processes and membrane dynamics.

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1 mg

$30.00

5 mg

$80.00

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Cat. No.: A57352

CAS No.: 1416313-72-8

Dynole 2−24

Dynole 2-24 is an indole-based inhibitor of dynamin GTPase, demonstrating an IC50 of 0.56 μM for dynamin I. This compound exhibits low toxicity and enhanced efficacy against both dynamin I and II in vitro and in cellular models, with an IC50 of 1.9 μM for clathrin-mediated endocytosis. Additionally, Dynole 2-24 displays 4.4-fold selectivity for dynamin I, making it a valuable tool for studying the mechanisms of clathrin-mediated endocytosis and dynamin-related cellular processes.

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5 mg

$150.00

10 mg

$235.00

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Cat. No.: A57354

CAS No.: 2226517-75-3

Dynapyrazole-A

Dynapyrazole-A is a selective dynamin inhibitor that inhibits the ATPase activity of microtubule-stimulated dynamin while sparing its microtubule-independent basal activity. This compound is valuable for studying the role of dynamin in vesicle trafficking and membrane dynamics. Its specificity makes it an important tool for researchers investigating dynamin-related cellular processes and potential therapeutic targets.

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5 mg

$35.00

10 mg

$60.00

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Cat. No.: A57359

CAS No.: 1345853-50-0

Dynamin IN-1

Dynamin IN-1 is a selective inhibitor of dynamin, exhibiting an IC50 value of 1.0 µM. This compound modulates endocytosis by interfering with the functional dynamics of dynamin, making it a valuable tool for investigating mechanistic pathways in cellular trafficking. Its application spans various research areas, including cell biology and pharmacology, where the regulation of endocytic pathways is critical.

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5 mg

$120.00

10 mg

$195.00

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Cat. No.: A57362

CAS No.: 1120-02-1

Trimethyloctadecylammonium bromide

Trimethyloctadecylammonium bromide is a potent inhibitor of dynamin, demonstrating an IC50 value of 1.9 μM for dynamin I. This compound is also noted for its antibacterial properties, particularly against Staphylococcus aureus. It serves as a valuable tool in studying dynamin-mediated processes and exploring bacterial pathogenesis mechanisms in research applications.

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Cat. No.: A57364

CAS No.: 1345853-49-7

Dynamin IN-2

Dynamin IN-2 is a potent inhibitor of dynamin I, targeting its GTPase activity with an IC50 of 1.0 μM. This compound effectively interferes with clathrin-mediated endocytosis (CME), exhibiting an IC50 of 9.5 μM. Dynamin IN-2 is a valuable tool for investigating the role of dynamin in cellular processes and the mechanisms of endocytosis in biochemical research.

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1 mg

$115.00

5 mg

$285.00

All 7 sizes

Cat. No.: A57372

CAS No.: 1440126-94-2

Pyrimidyn 7

Pyrimidyn 7 is a selective inhibitor of dynamin I and II, exhibiting IC50 values of 1.1 μM and 1.8 μM, respectively. This compound functions by competitively inhibiting the binding of GTP and phospholipids to dynamin I, thereby interfering with clathrin-mediated endocytosis (CME). Pyrimidyn 7 has demonstrated effectiveness in inhibiting the uptake of transferrin and epidermal growth factor (EGF) in various non-neuronal cell lines, making it a valuable tool for research in cell biology and endocytic processes.

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Cat. No.: A57373

CAS No.: 112-18-5

N,N-Dimethyldodecylamine

N,N-Dimethyldodecylamine is a selective inhibitor of dynamin I, demonstrating an IC50 value of 14.79 μM for its GTPase activity. This compound is valuable for research into diseases linked to endocytic dysfunction, including Alzheimer's disease and Huntington's disease. Its inhibition of dynamin I offers insights into pathways that may be disrupted in these neurodegenerative conditions.

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Cat. No.: A57374

CAS No.: 1367579-04-1

Rhodady C10

Rhodady C10 is a potent inhibitor of dynamin I GTPase, targeting the essential role of dynamin in membrane trafficking processes. By obstructing receptor-mediated endocytosis with an IC50 of 7 μM, Rhodady C10 provides valuable insights into the dynamics of clathrin-independent endocytosis, phagocytosis, and caveolae internalization. This compound is instrumental for research applications aimed at dissecting cellular uptake mechanisms and understanding the intricacies of endocytic pathways.

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