Microtubule/Tubulin

Cat. No.

A12954

CAS No.

474645-27-7

Monomethyl auristatin E

Synonyms: MMAE

Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.

Cat. No.

A14328

CAS No.

305841-29-6

Sagopilone

Synonyms: DE 03757; ZK 219477; ZK-EPO

Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity.

Cat. No.

A14980

CAS No.

78454-17-8

7-Epi 10-Desacetyl Paclitaxel

Synonyms: Ormosin VI

7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

Cat. No.

A21001

CAS No.

205304-86-5

Tubulysin A

Synonyms: TubA

Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.

Cat. No.

A24805

CAS No.

74805-91-7

Methylophiopogonanone B

Methylophiopogonanone B is a homoisoflavonoid that serves as a Ras activator. Isolated from the root of Ophiopogon japonicus, it exhibits potent antioxidant properties. This compound enhances GTP-Rho levels and activates the Rho signaling pathway, thereby inducing morphological changes in cells, such as actin cytoskeletal reorganization, dendrite retraction, and stress fiber formation. It is a valuable reagent for research into cellular signaling and structural dynamics.

Cat. No.

A31269

CAS No.

134954-57-7

Taccalonolide E

Taccalonolide E is a microtubule stabilizer that enhances microtubule polymerization and stability, leading to disruption of mitotic spindle formation. This compound effectively induces apoptosis in various cancer cell types by activating pathways associated with cell cycle arrest. Taccalonolide E is useful for research involving cancer biology, specifically in studies targeting microtubule dynamics and apoptotic mechanisms.

Cat. No.

A44777

CAS No.

301844-13-3

Flutax-2

Flutax-2 is a fluorescent derivative of Paclitaxel, functioning as a microtubule stabilizer through specific binding to polymerized αβ-tubulin dimers. This reagent is ideal for imaging microtubules in live cells, isolated cytoskeletons, and certain parasitic organisms, with excitation and emission wavelengths of 496 nm and 526 nm, respectively. Its high sensitivity enables researchers to investigate microtubule dynamics and cellular processes in real-time applications.

Cat. No.

A54818

CAS No.

849213-15-6

TPI-287

TPI-287 is a microtubule stabilizer that effectively penetrates the blood-brain barrier. This compound demonstrates significant inhibitory effects on metastatic colonization of breast cancer in the brain. TPI-287 is useful in research aimed at understanding tumor progression and developing therapeutic strategies for brain metastases.

Cat. No.

A54832

CAS No.

108885-69-4

Taccalonolide B

Taccalonolide B is a microtubule stabilizer that targets tubulin, exhibiting notable antitumor activity. This compound demonstrates efficacy in vitro against cell lines with overexpression of P-glycoprotein (Pgp) and multidrug-resistance protein 7 (MRP7). Taccalonolide B effectively inhibits the growth of SK-OV-3 cells, yielding an IC50 value of 208 nM, making it a valuable tool for cancer research and drug resistance studies.

Cat. No.

A54862

CAS No.

2699937-76-1

Microtubule stabilizer-1

Microtubule Stabilizer-1 targets microtubule stabilization, enhancing the levels of acetylated α-tubulin (AcTub) in neuronal cells. This compound effectively prevents the loss of microtubules induced by Okadaic acid treatment, making it a valuable tool for investigating Alzheimer’s disease and related neurodegenerative tauopathies. Its ability to penetrate the blood-brain barrier further supports its application in neuroscience research.

Cat. No.

A54941

CAS No.

156413-68-2

2'-Deoxy-PTX

2'-Deoxy-PTX is a derivative of Paclitaxel that functions as a microtubule assembly inducer. It binds efficiently to GMPcPP-stabilized microtubules, exhibiting a binding affinity with a Kaapp of 0.50 × 10^6 M^-1. By promoting the assembly of tubulin into stable microtubules, 2'-Deoxy-PTX serves as a valuable reagent in cancer research, particularly in studies focused on prostate cancer.

Cat. No.

A54945

CAS No.

186348-23-2

Ortataxel

Synonyms: IDN 5109; BAY 59-8862

Ortataxel is a novel antitumor agent that functions as a microtubule stabilizer, effectively disrupting cell division. It demonstrates significant cytotoxic activity against various drug-sensitive and resistant cancer cell lines, making it a valuable tool for cancer research. Its potential applications include assessing drug resistance mechanisms and exploring combination therapies in preclinical studies.

Cat. No.

A54967

CAS No.

1201916-31-5

TCS 2210

TCS 2210 is a neuronal differentiation inducer that promotes the differentiation of mesenchymal stem cells (MSCs) into neuronal lineages. This compound enhances the expression of key neuronal markers, including β-III tubulin and neuron-specific enolase (NSE), making it a valuable tool for research in neurogenesis and neural cell development. Its application supports investigations into neurodegenerative diseases and potential regenerative therapies.

Cat. No.

A55026

CAS No.

710280-48-1

EVs inducer-1

EVs inducer-1 is an extracellular vesicle (EV) release inducer that targets tubulin polymerization. This compound enhances the secretion of immunostimulatory EVs from antigen-presenting cells, particularly increasing EV particle release from dendritic cells and elevating CD63 reporter gene activity. Additionally, EVs inducer-1 inhibits the viability of proliferating cells, making it a valuable tool for research in immune regulation and EV biology.

Cat. No.

A55032

CAS No.

691868-19-6

Isofludelone

Synonyms: KOS-1803

Isofludelone is a microtubule stabilizer that demonstrates significant antitumor activity, making it a valuable compound for cancer research, particularly in the study of solid tumors. By promoting microtubule stabilization, isofludelone can disrupt normal cellular mechanisms, leading to potential therapeutic advances in oncology. Its application in research may provide insights into the pathological processes associated with tumorigenesis and aid in the development of effective treatments.

Cat. No.

A55034

CAS No.

331749-88-3

Centmitor-1

Synonyms: Cent-1

Centmitor-1 is a potent mitotic arrest inducer that targets microtubule dynamics by modulating microtubule plus-ends. Its application in cell studies reveals significant phenotypes, including chromosome alignment defects, multipolar spindle formation, centrosome fragmentation, and activation of the spindle assembly checkpoint. Centmitor-1 serves as a valuable tool for investigating mitotic processes and exploring therapeutic strategies in cancer research.