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DNA Repair

DNA repair inhibitors and activators act on enzymes that detect and fix damaged bases and broken strands. A 1993 review estimated that hydrolysis and oxidation damage thousands of DNA bases in every cell each day. In base excision repair, 8-oxoguanine DNA glycosylase 1 (OGG1) excises oxidized guanine, and apurinic/apyrimidinic endonuclease 1 (APE1) then cuts the abasic site. TH10785 is listed as an OGG1 activator, whereas APE1-IN-1 inhibits APE1. DNA repair protein RAD52 homolog (RAD52) became a target after a 2011 study found its loss lethal in cells lacking breast cancer susceptibility protein 2 (BRCA2). D-I03 inhibits RAD52, HAMNO blocks replication protein A (RPA), and CD00509 inhibits tyrosyl-DNA phosphodiesterase 1 (TDP1).

Items 26-27 of 27

  • SU0268
    Cat. No.
    A57732
    CAS No.
    2210228-45-6

    SU0268

    SU0268 is a selective inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1), a key enzyme involved in the repair of oxidative DNA damage. This compound has been shown to modulate inflammatory responses, particularly during infections caused by Pseudomonas aeruginosa. Its use in research can provide insights into oxidative stress and its role in inflammatory diseases, making it valuable for studying DNA repair mechanisms and host-pathogen interactions.

    In stock View Details
    1 mg
    $35.00
    5 mg
    $80.00
    All 6 sizes
  • OGG1-IN-08
    Cat. No.
    B18103
    CAS No.
    350997-39-6

    OGG1-IN-08

    OGG1-IN-08 is a selective inhibitor of 8-oxoguanine DNA glycosylase-1 (OGG1), exhibiting an IC50 value of 0.22 μM. This compound effectively reduces both the glycosylase and lyase activities of OGG1, making it a valuable tool for investigating oxidative DNA damage repair mechanisms. Research applications include studies on DNA repair pathways and the role of OGG1 in various biological processes and disease states.

    In stock View Details
    5 mg
    $50.00
    10 mg
    $90.00
    All 5 sizes

Items 26-27 of 27

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