DNA Repair | Adooq Bioscience

Cat. No.: A41868

CAS No.: 2446767-14-0

TX-2552

TX-2552 is an orally active inhibitor of tyrosine DNA phosphodiesterase 1 (TDP1), exhibiting an IC50 value of 0.62 μM. This compound has been shown to enhance the clastogenic activity of Topotecan in mouse bone marrow cells, as well as to amplify the anti-tumor effects of Topotecan in Krebs-2 ascites tumor mouse models. TX-2552 is relevant for research applications focused on DNA repair mechanisms and cancer therapies.

In stock View Details

5 mg

$130.00

10 mg

$215.00

All 5 sizes

Cat. No.: A42239

CAS No.: 21170-34-3

NSC-88915

NSC-88915 is a selective inhibitor of Tdp1 (tyrosyl-DNA phosphodiesterase 1), exhibiting an IC50 of 7.7 μM. This compound, a C21-subsituted progesterone derivative, has demonstrated significant potential in research applications focused on DNA damage repair mechanisms. It can be utilized to study the role of Tdp1 in cellular processes and may contribute to the understanding of therapeutic strategies for diseases associated with nucleotide excision repair and genomic stability.

In stock View Details

All 3 sizes

Cat. No.: A53808

CAS No.: 1648707-79-2

UNC3474

UNC3474 is a small molecule ligand that selectively binds to the aromatic methyl-lysine binding cage of 53BP1, exhibiting a dissociation constant (Kd) of 1.0 ± 0.3 μM. This binding inhibits the recruitment of 53BP1 to DNA double-strand breaks (DSBs) by stabilizing a pre-existing autoinhibited state of the protein within cells. UNC3474 is a valuable tool for researchers studying DNA damage response mechanisms and the regulation of genomic stability.

In stock View Details

All 4 sizes

Cat. No.: A56939

CAS No.: 1225141-73-0

D-G23

D-G23 is a selective inhibitor of RAD52, which plays a critical role in DNA repair mechanisms. By disrupting RAD52-mediated pathways, D-G23 effectively suppresses the proliferation of BRCA1- and BRCA2-deficient cancer cells. This compound is particularly relevant for research involving homologous recombination-related cancers, including hereditary breast and ovarian cancers associated with BRCA1 and BRCA2 mutations.

View Details

Out of stock

All 3 sizes

Cat. No.: A57732

CAS No.: 2210228-45-6

SU0268

SU0268 is a selective inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1), a key enzyme involved in the repair of oxidative DNA damage. This compound has been shown to modulate inflammatory responses, particularly during infections caused by Pseudomonas aeruginosa. Its use in research can provide insights into oxidative stress and its role in inflammatory diseases, making it valuable for studying DNA repair mechanisms and host-pathogen interactions.

In stock View Details

1 mg

$35.00

5 mg

$80.00

All 6 sizes

Cat. No.: B18103

CAS No.: 350997-39-6

OGG1-IN-08

OGG1-IN-08 is a selective inhibitor of 8-oxoguanine DNA glycosylase-1 (OGG1), exhibiting an IC50 value of 0.22 μM. This compound effectively reduces both the glycosylase and lyase activities of OGG1, making it a valuable tool for investigating oxidative DNA damage repair mechanisms. Research applications include studies on DNA repair pathways and the role of OGG1 in various biological processes and disease states.

In stock View Details

5 mg

$50.00

10 mg

$90.00

All 5 sizes