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Bioluminescence: Luciferins & Luciferase
This category includes luciferin substrates, luciferase enzymes and luciferase modulators for laboratory research. The selection covers D-luciferin and its salts, luciferin analogs, coelenterazine and its derivatives, firefly and bacterial luciferases, and luciferase inhibitors and an activator. These products are listed for bioluminescence and reporter-assay research. Check each product record for its intended enzyme system, substrate requirements and supporting references.
Firefly luciferase-IN-1 is a highly potent and reversible inhibitor of firefly luciferase, exhibiting an IC50 value of 0.25 nM. This compound is valuable for studying luciferase activity and its applications in bioluminescent assays. Its ability to modulate luciferase function makes it an important tool for researchers investigating gene expression and protein interactions in various biological contexts.
Luciferase-IN-4 is a potent inhibitor of luciferase, exhibiting an IC50 of 4.1 μM against the enzyme. Specifically, it demonstrates effective inhibition of purified luciferase from Photinus pyralis, with a lower IC50 value of 2.0 μM. This compound is valuable for research applications involving luciferase activity modulation in various biological assays.
D-Luciferin 6'-methyl ether is an inhibitor of firefly luciferase, targeting the enzyme responsible for bioluminescence in fireflies. This compound serves as a valuable tool in the study of luciferase activity and its regulatory mechanisms. It is particularly useful in research applications involving bioluminescence assays and the investigation of dinucleoside polyphosphate synthesis.
(Rac)-Luciferin 6′-methyl ether sodium is a potent inhibitor of the firefly luciferase derived from Photinus pyralis (PpyLuc), exhibiting an IC50 of 0.1 μM. This analog of D-luciferin demonstrates non-specific interactions at both ATP- and luciferin-binding sites within the PpyLuc active site. It is utilized in research applications involving bioluminescence assays and studies on enzyme kinetics, providing insights into luciferase activity and inhibition.
D-Luciferin 6'-methyl ether is a potent inhibitor of the Photinus pyralis luciferase (PpyLuc), with an IC50 value of 0.1 µM. This D-luciferin analog exhibits non-specific interactions at the ATP and luciferin-binding sites within the active site of PpyLuc. It is utilized in various research applications, particularly in studying bioluminescence and enzyme kinetics related to luciferase activity.
Firefly luciferase-IN-3 is a potent inhibitor of ATP-dependent luciferase, specifically targeting Firefly luciferase and exhibiting nanomolar inhibitory activity against NanoLuc with a pIC50 of 7.5. This compound is valuable for research applications involving bioluminescence assays, allowing for the detailed study of luciferase activity and its biological implications. Its specificity and efficacy make it a crucial tool for investigating cellular processes and signal transduction pathways mediated by luciferases.
Firefly luciferase-IN-5 is a potent inhibitor of ATP-dependent luciferase, specifically targeting Firefly luciferase. It demonstrates nanomolar-level inhibitory activity against various luciferase variants, including GRLuc (pIC50 = 8.5), RLuc8 (pIC50 = 7.5), and RLuc (pIC50 = 5.5). This inhibitor is valuable for research applications involving luciferase-based assays, enabling precise modulation of bioluminescent signaling and facilitating studies in gene expression, signal transduction, and molecular imaging.
Luciferase-IN-3 is an inhibitor of ATP-dependent luciferase, specifically targeting the firefly luciferase enzyme. It effectively inhibits Phrixotrichus pyralis luciferase with an IC50 value of 3.2 μM, demonstrating its potential as a tool for studying bioluminescent processes. This compound is primarily used in research applications focusing on bioluminescence assays and related biochemical studies. Its minimal inhibitory effect on R. reniformis luciferase allows for specificity in experimental design involving firefly luciferase.
Firefly luciferase-IN-2 is a selective inhibitor of ATP-dependent luciferase, specifically targeting the P. pyralis luciferase enzyme, a crucial component of bioluminescence in fireflies. With an IC50 value of 0.15 μM, this compound demonstrates potent inhibitory activity against P. pyralis luciferase, while exhibiting negligible effect on R. reniformis luciferase. Firefly luciferase-IN-2 is valuable for research applications involving bioluminescence, enzyme activity studies, and the exploration of cellular signaling pathways.
Firefly luciferase-IN-4 is a potent inhibitor of ATP-dependent luciferase, specifically targeting firefly luciferase activity. With a nanomolar inhibitory potency (pIC50 = 6.5), this compound serves as a valuable tool for studying luciferase-mediated bioluminescence in various biological systems. Its applications include elucidating signaling pathways and enhancing the understanding of gene expression assays utilizing luciferase as a reporter.
