- Cat. No.
- A16310
SR9011 hydrochloride
SR9011 is the agonist for REV-ERB-α with IC50 of 670 nM and REV-ERB-β with IC50 of 800 nM.
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Reverse erythroblastosis virus (REV-ERB) nuclear receptors regulate circadian gene expression. The alpha and beta receptors act as transcriptional repressors within networks connecting daily rhythms and metabolism. This category includes SR9009, SR9011 and GSK4112, catalogued as agonists, together with the antagonist SR8278. These annotations distinguish different approaches to receptor-related research without implying identical target profiles. The selection is relevant to studies of clock-associated transcription and metabolic regulation, with compound-specific properties described in the individual entries.
SR9011 is the agonist for REV-ERB-α with IC50 of 670 nM and REV-ERB-β with IC50 of 800 nM.
GSK4112 is a selective Rev-Erbα agonist with EC50 value of 250 nM.
SR10067 is a potent, selective and brain penetrant Rev-Erbα/β agonist, with IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively. SR10067 has anxiolytic activity.
SR9009 is a REV-ERBα/β agonist with IC50s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively.
SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
SR8278 is a competitive nuclear heme receptor REV-ERB synthetic antagonist.