Sphingolipids

Sphingolipids are membrane lipids built on a sphingoid base, with ceramide as their central intermediate. In cells, serine and palmitoyl-coenzyme A condense into sphingoid bases, which are then N-acylated to ceramides and extended into sphingomyelin and glycosphingolipids. Ceramides of defined chain length are represented by C6 Ceramide, C8-Ceramide and C24:1-Ceramide, which differ in how they partition into membranes. Glycosphingolipids include Cerebroside B, N-Acetylpsychosine and Ganglioside GT1b (bovine) ammonium, a sialylated ganglioside of neuronal membranes. Compounds directed at the biosynthetic enzymes are listed as well, among them the sphingomyelin synthase inhibitor malabaricone C and the sphingosine kinase inhibitor SKI-I.

Items 76-100 of 203

  • 3-Keto-C12-dihydrosphingosine hydrochloride
    Cat. No.
    A90230

    3-Keto-C12-dihydrosphingosine hydrochloride

    3-Keto-C12-dihydrosphingosine hydrochloride is a short-chain analog of the C18 chain-length 3-keto sphinganine (d18:0), targeting lipid metabolism. This compound exhibits biological activity relevant to sphingolipid signaling pathways and can be utilized in research focused on cell signaling, metabolic regulation, and lipid biology. Its unique chain length allows for specific studies of altered lipid composition and function in various biological systems.

    5 mg
    $675.00
    10 mg
    $1,110.00
    All 2 sizes
  • GD3βSph
    Cat. No.
    A90255

    GD3βSph

    Synonyms: GD3 Sphingosine (d18:1)

    GD3βSph is a sphingosine derivative of the ganglioside GD3, characterized by the absence of the fatty acyl group. This compound is primarily utilized in cancer research, particularly in studies investigating the role of gangliosides in tumor biology. GD3βSph serves as a valuable tool for examining the signaling pathways and cellular mechanisms influenced by gangliosides in cancerous cells.

    Out of stock

    All 3 sizes
  • 1-O-Acyl Ceramide (d18:1/24:1/24:1)
    Cat. No.
    A90330

    1-O-Acyl Ceramide (d18:1/24:1/24:1)

    1-O-Acyl Ceramide (d18:1/24:1/24:1) is a specific type of 1-O-Acyl-ceramide that targets lipid metabolism and integrity. This compound is essential for maintaining the barrier function of the lipid lamellae, contributing to cellular structural stability and signaling. It is valuable in research applications focusing on lipid biology, skin barrier properties, and related conditions.

    Out of stock

    All 3 sizes
  • C14 Galactosyl(ß) ceramide (d18:1/14:0)
    Cat. No.
    A90368

    C14 Galactosyl(ß) ceramide (d18:1/14:0)

    C14 Galactosyl(β) ceramide (d18:1/14:0) is a β-galactosylceramide, targeting sphingolipid metabolism. This compound plays a significant role in cell signaling and membrane structure, particularly in the context of myelin formation and neuronal function. It is essential for researchers studying sphingolipid biology and the role of glycosphingolipids in cellular processes, including neurodegenerative diseases and cancer.

    Out of stock

    All 3 sizes
  • 14:0 Dihydro SM (d18:0/14:0)
    Cat. No.
    A90397

    14:0 Dihydro SM (d18:0/14:0)

    14:0 Dihydro SM (d18:0/14:0) is a sphingomyelin derivative that primarily targets sphingolipid metabolism. This compound is essential for studying sphingomyelin synthesis and degradation pathways in cellular models. It is commonly used in research focused on membrane biology, signal transduction, and related diseases, particularly in the context of neurodegenerative disorders and cancer.

    Out of stock

    All 3 sizes
  • 1-O-Acyl Ceramide (d18:1/16:0/18:1)
    Cat. No.
    A90497

    1-O-Acyl Ceramide (d18:1/16:0/18:1)

    1-O-Acyl Ceramide (d18:1/16:0/18:1) targets lipid structures and is crucial for maintaining the integrity of the lipid lamellae. This class of 1-O-Acyl-ceramides contributes significantly to barrier function, which is vital for cellular protection and homeostasis. Research applications include studies on lipid metabolism, skin barrier function, and the exploration of ceramide-related signaling pathways in various biological processes.

    Out of stock

    All 3 sizes
  • CER1(d18:1/28:0/18:2)
    Cat. No.
    A90639

    CER1(d18:1/28:0/18:2)

    CER1(d18:1/28:0/18:2) is a skin ceramide that plays a crucial role in maintaining skin barrier integrity and hydration. It acts by replenishing ceramide levels within the stratum corneum, thereby enhancing moisture retention and protecting against transepidermal water loss. This reagent is particularly valuable for research focused on dermatological conditions, skin aging, and the development of moisturizers and barrier repair products.

    Out of stock

    All 3 sizes
  • C24:1 GB4 Ceramide (d18:1/24:1)
    Cat. No.
    A90685

    C24:1 GB4 Ceramide (d18:1/24:1)

    C24:1 GB4 Ceramide (d18:1/24:1) is a sphingolipid that plays a crucial role in cellular signaling and membrane structure. Its primary mechanism involves modulating lipid raft formation and influencing cell-to-cell communication. C24:1 GB4 Ceramide is utilized in research applications related to lipid metabolism, neurobiology, and cancer biology, providing insight into the pathophysiological roles of sphingolipids in various diseases.

    Out of stock

    All 3 sizes
  • IG4
    Cat. No.
    A90719

    IG4

    IG4 is a bioactive ceramide that targets lipid metabolism pathways. It plays a crucial role in cell signaling and membrane structure, making it significant for studies related to cellular stress responses, inflammation, and cancer biology. This compound is useful for researchers investigating lipid-related diseases and the therapeutic potential of ceramides in various biological contexts.

    Out of stock

    All 3 sizes
  • Fuc-GM1 Sphingosine (d18:1)
    Cat. No.
    A90727

    Fuc-GM1 Sphingosine (d18:1)

    Fuc-GM1 Sphingosine (d18:1) serves as a precursor to the Fuc-GM1 ganglioside, a crucial component in cellular membranes. This sphingosine variant plays a significant role in lipid metabolism and cell signaling pathways. It is essential for research applications focused on ganglioside biosynthesis and the exploration of membrane-related functions in physiological and pathological processes.

    Out of stock

    All 3 sizes
  • Biotin S1P
    Cat. No.
    A90778

    Biotin S1P

    Biotin S1P is a biotinylated sphingosine-1-phosphate (S1P) that serves as a valuable tool for biochemical studies. This compound can be conjugated to streptavidin, facilitating various applications in cell biology and biochemistry. Its unique structure allows for effective labeling and tracking of cellular processes involving lipid signaling pathways.

    0.1 mg
    $1,040.00
    All 1 sizes
  • GT3 Sphingosine (d18:1)
    Cat. No.
    A90896

    GT3 Sphingosine (d18:1)

    GT3 Sphingosine (d18:1) is a bioactive sphingolipid that plays a crucial role in cellular signaling and membrane structure. As a component of gangliosides, it is involved in various biological processes, including cell recognition, growth, and differentiation. This compound is valuable for research applications focusing on lipid biochemistry, neurobiology, and studies related to signal transduction pathways.

    Out of stock

    All 3 sizes
  • C16-Urea-Ceramide
    Cat. No.
    A90901

    C16-Urea-Ceramide

    C16-Urea-Ceramide is a bioactive ceramide that targets lipid metabolism pathways. It has been shown to exhibit important biological activities, including modulation of cell membrane integrity and signal transduction. This compound is primarily utilized in research applications focused on skin barrier function, inflammation, and the study of lipid-related disorders.

    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • GD2 Sphingosine (d18:1)
    Cat. No.
    A90918

    GD2 Sphingosine (d18:1)

    GD2 Sphingosine (d18:1) is a sphingolipid that plays a critical role in cellular signaling and membrane structure. It is primarily involved in cell recognition and adhesion, contributing to various biological processes such as neuronal differentiation and immune responses. This compound is valuable for research applications focused on sphingolipid metabolism, neurobiology, and cancer biology, particularly in studies involving GD2-expressing tumors.

    Out of stock

    All 3 sizes
  • IG7
    Cat. No.
    A90922

    IG7

    IG7 is a bioactive ceramide that functions primarily as a lipid mediator. It is involved in various cellular processes, including apoptosis and cell signaling pathways. This compound serves as a valuable tool in research related to lipid metabolism, cancer biology, and cell death mechanisms, providing insights into the role of ceramides in health and disease.

    Out of stock

    All 3 sizes
  • C18:2 Glucosyl(ß) ceramide (d18:1/18:2)
    Cat. No.
    A90937

    C18:2 Glucosyl(ß) ceramide (d18:1/18:2)

    C18:2 Glucosyl(β) ceramide (d18:1/18:2) is a β-glucosyl ceramide that primarily targets ceramide pathways. This compound is involved in various cellular processes, including cell signaling and membrane dynamics. It serves as a valuable tool for research into sphingolipid metabolism and its implications in diseases such as cancer and neurodegeneration.

    Out of stock

    All 3 sizes
  • C25 Ceramide (d18:1/25:0)
    Cat. No.
    A91034

    C25 Ceramide (d18:1/25:0)

    C25 Ceramide (d18:1/25:0) is a sphingolipid that plays a crucial role in cell membrane structure and cellular signaling. This ceramide exhibits bioactive properties, influencing cellular processes such as apoptosis, proliferation, and inflammation. C25 Ceramide is widely utilized in research to study lipid metabolism, cellular stress responses, and the role of sphingolipids in disease pathology.

    Out of stock

    All 3 sizes
  • C18:0 GM3(Neu5Gc) Ceramide (d18:1/18:0)
    Cat. No.
    A91080

    C18:0 GM3(Neu5Gc) Ceramide (d18:1/18:0)

    C18:0 GM3(Neu5Gc) Ceramide (d18:1/18:0) is a sphingolipid that plays a crucial role in cell membrane structure and signaling. This compound acts as a bioactive lipid involved in cellular interactions and recognition processes. It is primarily utilized in lipid research, particularly in studies related to cell signaling, neurobiology, and the role of glycosphingolipids in disease mechanisms.

    Out of stock

    All 3 sizes
  • C14 Glucosyl(ß) ceramide (d18:1/14:0)
    Cat. No.
    A91087

    C14 Glucosyl(ß) ceramide (d18:1/14:0)

    C14 Glucosyl(β) ceramide (d18:1/14:0) is a β-glucosyl ceramide that targets ceramide signaling pathways. This compound exhibits significant activity in modulating lipid metabolism and cell signaling processes. It is commonly used in research applications related to sphingolipid biology, cell differentiation, and membrane dynamics.

    Out of stock

    All 3 sizes
  • C24:1 GD2 Ceramide (d18:1/24:1)
    Cat. No.
    A91164

    C24:1 GD2 Ceramide (d18:1/24:1)

    C24:1 GD2 Ceramide (d18:1/24:1) is a sphingolipid that features a long-chain fatty acid moiety. This compound plays a critical role in membrane dynamics by interacting with various membrane lipids, thus facilitating the stable anchoring of GD2 to the cell surface. C24:1 GD2 Ceramide has implications in studies focused on cell signaling, cancer biology, and the intricate roles of sphingolipids in cellular processes.

    Out of stock

    All 3 sizes
  • C23 Galactosyl(β) ceramide (d18:1/23:0)
    Cat. No.
    A91221

    C23 Galactosyl(β) ceramide (d18:1/23:0)

    C23 Galactosyl(β) ceramide (d18:1/23:0) is a galactosylceramide that targets ceramide metabolism. This compound plays a critical role in cell signaling and membrane formation, influencing cellular differentiation and apoptosis. C23 Galactosyl(β) ceramide is utilized in research related to neurobiology, particularly in the study of myelin sheath development and neurological disorders.

    Out of stock

    All 3 sizes
  • 1-O-Acyl ceramide (d18:1/18:1/18:1)
    Cat. No.
    A91317

    1-O-Acyl ceramide (d18:1/18:1/18:1)

    1-O-Acyl ceramide (d18:1/18:1/18:1) serves as an important class of lipid molecules primarily involved in maintaining the structural integrity of cellular membranes. This compound is essential for preserving the barrier function of lipid lamellae, thereby contributing to lipid homeostasis and cellular signaling processes. Its applications extend to research focused on skin biology, barrier dysfunction, and various lipid-related pathways in cellular physiology.

    Out of stock

    All 3 sizes
  • 1-desoxymethylsphinganine
    Cat. No.
    A91329

    1-desoxymethylsphinganine

    1-Desoxymethylsphinganine is a sphingoid base and a structural analog of sphinganine. It functions as a precursor in the biosynthesis of bioactive sphingolipids. This compound is valuable for studying sphingolipid metabolism and the roles of sphingoid bases in cellular signaling pathways. Research applications include exploration of neurodegenerative diseases and investigations into cancer biology.

    Out of stock

    All 3 sizes
  • C17 3'-Sulfo galactosylceramide (d18:1/17:0)
    Cat. No.
    A91331

    C17 3'-Sulfo galactosylceramide (d18:1/17:0)

    Synonyms: (3'-Sulfo)Galβ-Cer (d18:1/17:0); N-Heptadecanoyl sulfatide; C17 Sulfatide

    C17 3'-Sulfo galactosylceramide (d18:1/17:0) is a sulfatide belonging to the glycolipid class, primarily recognized for its role in cellular signaling and membrane structure. This reagent is particularly valuable in the mass spectrometric quantitative analysis of urinary samples and is applicable in studies of metachromatic leukodystrophies. Its use can facilitate research into metabolic disorders associated with glycolipid metabolism.

    1 mg
    $855.00
    All 1 sizes
  • C24:0(2R-OH) Mono-sulfo galactosyl(ß) ceramide (d18:1/24:0)
    Cat. No.
    A91440

    C24:0(2R-OH) Mono-sulfo galactosyl(ß) ceramide (d18:1/24:0)

    C24:0(2R-OH) Mono-sulfo galactosyl(β) ceramide (d18:1/24:0) is a 2-hydroxy ceramide that targets cellular membrane dynamics. It exhibits key biological activities related to cellular signaling and lipid metabolism. This compound is valuable for research applications involving sphingolipid biology, neurobiology, and understanding the role of glycosphingolipids in cell-cell interactions and signal transduction pathways.

    Out of stock

    All 3 sizes

Items 76-100 of 203

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