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Sphingolipids

Sphingolipids are membrane lipids built on a sphingoid base, with ceramide as their central intermediate. In cells, serine and palmitoyl-coenzyme A condense into sphingoid bases, which are then N-acylated to ceramides and extended into sphingomyelin and glycosphingolipids. Ceramides of defined chain length are represented by C6 Ceramide, C8-Ceramide and C24:1-Ceramide, which differ in how they partition into membranes. Glycosphingolipids include Cerebroside B, N-Acetylpsychosine and Ganglioside GT1b (bovine) ammonium, a sialylated ganglioside of neuronal membranes. Compounds directed at the biosynthetic enzymes are listed as well, among them the sphingomyelin synthase inhibitor malabaricone C and the sphingosine kinase inhibitor SKI-I.

Cat. No.

B20190

CAS No.

73039-25-5

C18:1 Galactosyl(β) ceramide (d18:1/18:1(9Z))

C18:1 Galactosyl(β) ceramide (d18:1/18:1(9Z)) is a lipid that primarily serves as a critical component in the formulation of lipid nanoparticles (LNPs) for drug delivery applications. Its unique structure allows for enhanced biocompatibility and stability of lipid-based formulations. This compound is instrumental in facilitating targeted delivery and improving the pharmacokinetic profiles of therapeutic agents in various biomedical research studies.

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Cat. No.

B20196

CAS No.

1246303-18-3

C24 Dihydroceramide-1-Phosphate (d18:0/24:0) ammonium

C24 Dihydroceramide-1-Phosphate (d18:0/24:0) ammonium is a specialized ceramide lipid that plays a crucial role in cell signaling and membrane dynamics. This compound is involved in various biological processes, including cell growth, differentiation, and apoptosis. It serves as a valuable tool in research applications focused on lipid metabolism, inflammatory responses, and neurobiology, providing insights into the function and regulation of sphingolipid signaling pathways.

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Cat. No.

B20197

CAS No.

1246298-46-3

17:0 (2R-OH)-Ceramide

17:0 (2R-OH)-Ceramide is a bioactive ceramide that plays a crucial role in cellular signaling and membrane structure. It is known for its involvement in lipid metabolism and cell differentiation processes. This compound is utilized in research applications exploring lipid-mediated signaling pathways, neurodegenerative diseases, and skin barrier function.

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Cat. No.

B20198

CAS No.

108283-62-1

Glucosyl β sphingosine (d20:1)

Glucosyl β sphingosine (d20:1) is a glycosphingolipid that plays a crucial role in cellular signaling and membrane structure. It serves as a vital component in the biosynthesis of complex lipids and is involved in various biological processes such as cell recognition and differentiation. This compound is used in research focused on lipid metabolism, neurobiology, and diseases related to sphingolipid dysfunction.

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Cat. No.

B20200

CAS No.

2260670-34-4

CER9 (t18:0/26:0/18:1)

CER9 (t18:0/26:0/18:1) is a ceramide that plays a crucial role in cellular signaling and membrane structure. This lipid is involved in various biological activities, including apoptosis, differentiation, and inflammation modulation. CER9 is valuable for research in cell biology and therapeutic applications related to metabolic disorders and skin conditions. Its unique fatty acid composition contributes to its distinct biological properties, making it a useful tool for studying lipid metabolism and related pathways.

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Cat. No.

B20204

CAS No.

1246303-16-1

1-Desoxymethylsphingosine (m17:1)

1-Desoxymethylsphingosine (m17:1) is a sphingosine derivative that serves as a bioactive lipid molecule. It is known to modulate various cellular functions, including apoptosis and cell proliferation, by targeting sphingosine pathways. This compound is valuable for research in areas such as cancer biology, neurobiology, and inflammation, where lipid signaling plays a critical role in disease progression and therapeutic responses.

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Cat. No.

B20263

CAS No.

1246298-52-1

18:1 (2R-OH) Ceramide

18:1 (2R-OH) Ceramide is a bioactive sphingolipid that plays a crucial role in cellular signaling and membrane structure. It is involved in regulating various biological processes, including apoptosis, cell differentiation, and inflammation. This compound is widely used in research applications focused on lipid metabolism, cellular stress responses, and skin barrier function studies. Its unique structure allows for the exploration of ceramide's role in health and disease.

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Cat. No.

B20461

CAS No.

2707481-39-6

C18:0 GT1b (d18:1/18:0) triammonium

C18:0 GT1b (d18:1/18:0) triammonium is a glycosphingolipid that primarily engages with cell membrane structures and signaling pathways. It plays a crucial role in modulating cell-cell interactions and is utilized in research applications studying neuronal function, cellular adhesion, and lipid metabolism. Its unique structural properties make it a valuable tool for exploring the biochemical processes associated with membrane dynamics and disease mechanisms.

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Cat. No.

B20501

CAS No.

1645269-61-9

1-Deoxy-Cer

1-Deoxy-Cer is a ceramide that serves as a crucial component of the skin permeability barrier. It plays a significant role in maintaining skin hydration and integrity. This compound is useful for research applications focused on skin biology, barrier function, and lipid metabolism.

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Cat. No.

B20701

CAS No.

1407154-31-7

cis-4-Methylsphingosine

Cis-4-Methylsphingosine is a synthetic analogue of sphingosine that functions as a modulator of sphingosine-1-phosphate receptors. It exhibits key biological activities related to cell signaling, particularly influencing pathways involved in cell proliferation and survival. This compound is utilized in research applications focused on lipid signaling, inflammation, and cancer biology, making it a valuable tool for studying the roles of sphingolipids in various physiological processes.

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Cat. No.

B20717

CAS No.

35823-62-2

C18(2R-OH) Galactosyl(β) ceramide

C18(2R-OH) Galactosyl(β) ceramide is a lipid that serves as a key component in the formulation of lipid nanoparticles (LNPs) for drug delivery applications. Its structural properties enhance the encapsulation and stabilization of therapeutic agents, making it an important reagent for research in targeted drug delivery and nanomedicine. This compound is valuable in studies focused on improving the bioavailability and efficacy of various pharmaceuticals.

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Cat. No.

B20758

CAS No.

41679-33-8

4E,8Z-Sphingadiene

4E,8Z-Sphingadiene is a sphingosine derivative with important roles in lipid signaling and metabolism. It serves as a key intermediate in the synthesis of complex sphingolipids and participates in various cellular processes, including cell proliferation and apoptosis. This compound can be utilized in research focused on sphingolipid biology, cellular signaling pathways, and the exploration of lipid-mediated physiological responses.

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Cat. No.

B20760

CAS No.

474944-04-2

C8 Ceramide-1-phosphate (d17:1/8:0) ammonium

C8 Ceramide-1-phosphate (d17:1/8:0) ammonium is a lipid molecule that serves as a bioactive sphingolipid. It plays a crucial role in cellular signaling processes, particularly in cellular proliferation and apoptosis. This reagent is employed in research applications focused on lipid metabolism, cellular stress responses, and various signal transduction pathways. Enhanced understanding of ceramide-1-phosphate can contribute to insights into related diseases, including cancer and neurodegenerative disorders.

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Cat. No.

B20782

CAS No.

123065-42-9

C18 Ceramide (d17:1/18:0)

C18 Ceramide (d17:1/18:0) is a sphingolipid that plays a crucial role in cell signaling and membrane structure. This ceramide is involved in various biological processes, including apoptosis, inflammation, and cell differentiation. It is commonly used in studies related to lipid metabolism, neurobiology, and cancer research, providing valuable insights into the role of ceramides in cellular functions and disease mechanisms.

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Cat. No.

B20790

CAS No.

474944-00-8

C20 Ceramide (d17:1/20:0)

C20 Ceramide (d17:1/20:0) is a bioactive lipid that plays a critical role in cell signaling and metabolism. It is involved in cellular processes such as apoptosis, differentiation, and inflammation. This compound is widely used in research focused on understanding the functions of sphingolipids and their impact on various diseases, including cancer and metabolic disorders.

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Cat. No.

B20791

CAS No.

109719-59-7

C18:1 Lactosyl(β) ceramide (d18:1/18:1)

C18:1 Lactosyl(β) ceramide (d18:1/18:1) is a sphingolipid that primarily functions as a key component in the formation of lipid nanoparticles (LNPs). Its unique structure enhances the stability and bioavailability of encapsulated therapeutic agents. This compound is particularly useful in drug delivery applications, facilitating targeted delivery and effective cellular uptake of various therapeutics in research settings.

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Cat. No.

B20806

CAS No.

2707415-34-5

C17:0 GD1a (d18:1/17:0) ammonium

C17:0 GD1a (d18:1/17:0) ammonium is a glycosphingolipid that functions as a cellular membrane component and signaling molecule. It is involved in cell recognition and adhesion processes, influencing neuronal function and development. This reagent is valuable for research applications in neurobiology, particularly in studies focusing on glycolipid functions, signal transduction pathways, and the role of glycosphingolipids in disease mechanisms.

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Cat. No.

B20828

CAS No.

474943-68-5

C2 Ceramide-1-phosphate ammonium

C2 Ceramide-1-phosphate ammonium is a form of ceramide that plays a crucial role in cellular signaling and membrane dynamics. It is involved in various biological processes, including cell growth, differentiation, and apoptosis. This reagent is primarily utilized in lipid research and studies investigating the molecular mechanisms of sphingolipids in health and disease.

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Cat. No.

B20834

CAS No.

74645-26-4

C24:0 Galactosyl(β)ceramide(d18:1/24:0)

C24:0 Galactosyl(β)ceramide(d18:1/24:0) is a sphingolipid that serves as a key component in the formulation of lipid nanoparticles (LNPs) for drug delivery applications. Its unique structure contributes to enhanced membrane fluidity and stability, making it an essential reagent in the development of targeted therapies. This compound is utilized in lipid-based drug delivery systems, facilitating the encapsulation and delivery of therapeutic agents.

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Cat. No.

B20835

CAS No.

168395-96-8

C18(2S-OH) Galactosyl(β) ceramide

C18(2S-OH) Galactosyl(β) ceramide is a lipid compound that plays a crucial role in the formulation of lipid nanoparticles (LNPs) for targeted drug delivery applications. Its structural properties facilitate effective encapsulation and stabilization of therapeutic agents, enhancing their bioavailability. C18(2S-OH) Galactosyl(β) ceramide is valuable in research related to nanomedicine and lipid biochemistry, contributing to advancements in drug delivery systems.

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Cat. No.

B20837

CAS No.

1246298-47-4

17:0 (2S-OH)-Ceramide

17:0 (2S-OH)-Ceramide is a specific ceramide with unique structural features. This compound is essential for studying sphingolipid metabolism and its implications in cellular signaling pathways. Its biological activity includes modulation of cell differentiation, apoptosis, and inflammation, making it a valuable tool for research in cancer, neurobiology, and immunology.

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Cat. No.

B20838

CAS No.

1246303-19-4

1-O-Acyl ceramide (d18:1/18:1/17:0)

1-O-Acyl ceramide (d18:1/18:1/17:0) is a lipid molecule featuring a ceramide structure. This compound plays a critical role in cellular signaling and membrane dynamics. Its applications in research include studies on lipid metabolism, cell membrane integrity, and the investigation of ceramide's functions in various biological processes, including apoptosis and inflammation.

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Cat. No.

B20846

CAS No.

1246304-32-4

C24 Mono-Sulfo Galactosyl(β) Ceramide (d18:1/24:0) ammonium

C24 Mono-Sulfo Galactosyl(β) Ceramide (d18:1/24:0) ammonium is a glycosphingolipid that targets cellular membranes. It plays a crucial role in cellular processes, including cell signaling and recognition. This compound is frequently used in research related to lipid metabolism, membrane biology, and neurobiology, providing valuable insights into cellular interactions and functions.

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Cat. No.

B20852

CAS No.

1246298-53-2

18:1 (2S-OH) Ceramide

18:1 (2S-OH) Ceramide is a bioactive sphingolipid that plays a crucial role in cellular signaling and membrane structure. This ceramide is known to influence apoptosis, inflammation, and cell proliferation, making it essential for studies in lipid signaling pathways. It is widely utilized in research focused on cancer biology, neurodegenerative diseases, and metabolic disorders to explore the functional implications of sphingolipid metabolism.

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Cat. No.

B20861

CAS No.

2260670-28-6

18:0 (2S-OH) Sulfo GalCer ammonium

18:0 (2S-OH) Sulfo GalCer ammonium is a glycosphingolipid that serves as a critical component in cellular membranes. This compound plays a significant role in cell signaling and recognition processes, impacting various biological pathways. It is commonly utilized in research focused on lipid biochemistry, neuronal function, and the study of glycolipid interactions in cellular environments.

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