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Flavivirus

Flavivirus inhibitors target replication enzymes of dengue, Zika and related viruses. Flaviviruses are enveloped, positive-strand RNA viruses whose genome is translated into a single polyprotein. The viral protease formed by non-structural (NS) proteins NS2B and NS3 cleaves this polyprotein, and NS5 carries the RNA-dependent RNA polymerase (RdRp). NITD008, an adenosine nucleoside analog, was described in 2009 as an inhibitor of dengue virus replication. CN-716 dihydrochloride targets the NS2B-NS3 protease, and HeE1-2Tyr is listed as an RdRp inhibitor. DEPN-8 is listed as a substrate for measuring West Nile virus protease activity in enzyme assays. Compounds studied mainly against one virus also appear in the neighboring Dengue Virus category.

2 Items

  • Palonosetron
    Cat. No.
    A11535
    CAS No.
    135729-61-2

    Palonosetron

    Palonosetron is a selective 5-HT3 antagonist that effectively prevents acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition to its primary application in oncology, Palonosetron demonstrates moderate activity against flaviviruses and exhibits potent antiviral effects against Zika virus in mammalian cells. Furthermore, this compound has been associated with antidepressant properties, making it a valuable tool for diverse research applications in both oncology and virology.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • Palonosetron hydrochloride
    Cat. No.
    A11536
    CAS No.
    135729-62-3

    Palonosetron hydrochloride

    Palonosetron hydrochloride is a selective 5-HT3 receptor antagonist that primarily functions to prevent acute and delayed nausea and vomiting associated with chemotherapy. Beyond its primary application, Palonosetron hydrochloride demonstrates moderate activity against flaviviruses, including potent efficacy against the Zika virus in mammalian cells. Additionally, this compound has been associated with antidepressant effects, expanding its potential therapeutic applications in neurological research.

    In stock View Details
    25 mg
    $30.00
    50 mg
    $40.00
    All 5 sizes

2 Items

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