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Mycobacterium tuberculosis

Mycobacterium tuberculosis research compounds act on enzymes and proteins that the tuberculosis bacterium depends on. The genome of the laboratory strain H37Rv, sequenced in 1998, encodes an unusually large set of enzymes for lipid metabolism. Several entries inhibit decaprenylphosphoryl-β-D-ribose 2′-epimerase (DprE1), an enzyme required for arabinan synthesis in the cell wall. Benzothiazinones, represented here by BTZ043 (BTZ038, BTZ044) Racemate, were shown in 2009 to kill the bacterium by blocking this step. AZ7371 and DprE1-IN-8 are listed as further inhibitors of the same enzyme. PXYC1 and PXYC2 are antagonists of ribosomal protein S1 (RpsA), and MtTMPK-IN-8 inhibits mycobacterial thymidylate kinase. Cefsulodin sodium hydrate is listed as an inhibitor of mycobacterial protein tyrosine phosphatase B (mPTPB), a secreted virulence factor.

6 Items

  • PXYC1
    Cat. No.
    A46504
    CAS No.
    865098-81-3

    PXYC1

    PXYC1 is an antagonist of ribosomal protein S1 (RpsA), exhibiting dissociation constants (Kd) of 0.81 and 0.31 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA is critical in the trans-translation process of Mycobacterium tuberculosis, making PXYC1 a valuable tool for research focused on bacterial protein synthesis and potential therapeutic strategies against tuberculosis. This compound supports investigations into the molecular mechanisms of antibiotic action and resistance.

    In stock View Details
    5 mg
    $260.00
    10 mg
    $430.00
    All 5 sizes
  • PXYC12
    Cat. No.
    A46860
    CAS No.
    1112415-91-4

    PXYC12

    PXYC12 is an antagonist of ribosomal protein S1 (RpsA) with dissociation constants (Kd) of 2.67 and 4.67 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA is crucial in the trans-translation mechanism of Mycobacterium tuberculosis, making PXYC12 a valuable tool for studying bacterial protein synthesis and exploring potential therapeutic strategies against tuberculosis. This compound is ideal for research applications focusing on antimicrobial drug discovery and the modulation of ribosomal function.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • PXYC2
    Cat. No.
    A46948
    CAS No.
    865101-22-0

    PXYC2

    PXYC2 is a potent antagonist of ribosomal protein S1 (RpsA), demonstrating Kds of 6.35 and 5.11 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA is crucial for the trans-translation process in Mycobacterium tuberculosis, making it an important target for research into antibiotic resistance and bacterial pathogenicity. PXYC2 serves as a valuable tool for investigating the molecular mechanisms underlying Mycobacterial infections and for the development of new therapeutic strategies.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • PXYC13
    Cat. No.
    A46949
    CAS No.
    1031940-69-8

    PXYC13

    PXYC13 is an antagonist of ribosomal protein S1 (RpsA), exhibiting dissociation constants (Kd) of 7.61 μM and 8.50 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. This compound is a valuable tool for investigations into the trans-translation mechanism in Mycobacterium tuberculosis. Its ability to inhibit RpsA makes it relevant for research into the pathogen’s protein synthesis processes and potential therapeutic strategies.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • PXYD4
    Cat. No.
    A47118
    CAS No.
    2712534-78-4

    PXYD4

    PXYD4 is an antagonist of ribosomal protein S1 (RpsA), exhibiting dissociation constants (Kd) of 3.24 μM and 1.64 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. It is relevant for studies involving the trans-translation mechanism in Mycobacterium tuberculosis (Mtb), making it a valuable tool for exploring potential therapeutic strategies against this pathogen. PXYD4's ability to inhibit RpsA may contribute to our understanding of bacterial protein synthesis and its implications in antibiotic resistance.

    In stock View Details
    25 mg
    $1,800.00
    50 mg
    $2,285.00
    All 3 sizes
  • PXYD3
    Cat. No.
    A48884
    CAS No.
    2680554-46-3

    PXYD3

    PXYD3 is an antagonist of ribosomal protein S1 (RpsA), exhibiting dissociation constants (Kds) of 5.66 μM and 6.91 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA is crucial for the trans-translation process in Mycobacterium tuberculosis, making PXYD3 a valuable tool for researching antibiotic mechanisms and developing potential therapeutic agents against this pathogen. This compound facilitates studies on ribosomal function and interactions, contributing to the understanding of bacterial resistance mechanisms.

    In stock View Details
    25 mg
    $1,800.00
    50 mg
    $2,285.00
    All 3 sizes

6 Items

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