NMDA Receptors

Cat. No.

A11708

CAS No.

41100-52-1

Memantine hydrochloride

Synonyms: Namenda

Memantine hydrochloride is an antagonist at the NMDA receptor, binding to the ion channel site. it was used in the treatment of Parkinsonism.

Cat. No.

A13858

CAS No.

153322-06-6

ARL-15896

Synonyms: Lanicemine hydrochloride; AR-R15896AR

ARL-15896 is a novel N-methyl-D-aspartate receptor ion channel antagonist.

Cat. No.

A10251

CAS No.

75507-68-5

Flupirtine maleate

Synonyms: D 9998

Non-opioid analgesic with muscle relaxant properties.

Cat. No.

A11712

CAS No.

4682-36-4

Orphenadrine citrate

Synonyms: Norflex

Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

Cat. No.

A11842

CAS No.

60-27-5

Creatinine

Synonyms: NSC13123

Creatinine acts as a GABAA and NMDA receptor modulator, demonstrating antioxidant properties and metabolic regulation. It is produced through the non-enzymatic conversion of creatine and phosphocreatine in muscle, making its serum levels an important biomarker for renal function, muscle mass, and clinical outcomes. Creatinine is utilized in evaluating perioperative renal risk and has applications in research on neurodegenerative diseases, psychiatric disorders, acute and chronic kidney injury, and renal failure. Additionally, it can induce specific Cryptococcus species to produce creatinine deiminase, highlighting its role in metabolic studies.

Cat. No.

A11862

CAS No.

25451-15-4

Felbamate

Synonyms: Felbatol

Felbamate is an antagonist at the NMDA-associated glycine binding site.

Cat. No.

A11947

CAS No.

852918-02-6

TCN 201

TCN 201 is a NMDA receptor antagonist selective for NR1/NR2A over NR1/NR2B-containing receptors

Cat. No.

A12426

CAS No.

174575-17-8

SDZ 220-581

SDZ 220-581 is a competitive NMDA receptor antagonist (pKi = 7.7).

Cat. No.

A12757

CAS No.

1883518-31-7

GNE 0723

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.

Cat. No.

A12761

CAS No.

77086-22-7

(+)-MK 801 Maleate (Dizocilpine)

Synonyms: Dizocilpine maleate; Dizocilpine hydrogen maleate; MK 801; Dizocilpine

(+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM.

Cat. No.

A12946

CAS No.

119431-25-3

Eliprodil

Synonyms: SL-820715

Eliprodil is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).

Cat. No.

A13385

CAS No.

154106-92-0

RPR104632

RPR104632 is a specific antagonist of NMDA receptor, with potent neuroprotective properties.

Cat. No.

A13435

CAS No.

121917-57-5

(-)-MK 801 maleate [ (-)-Dizocilpine maleate]

Synonyms: MK801

(-)-MK 801 maleate acts as a potent, selective, and non-competitive NMDA receptor antagonist. It acts by binding to a site located within the NMDA associated ion channel.

Cat. No.

A13438

CAS No.

166974-23-8

GV-196771A

GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist.

Cat. No.

A13576

CAS No.

117928-94-6

Rapastinel (GLYX-13)

Synonyms: GLYX 13

GLYX-13 is a selective weak partial agonist of the glycine site of the NMDA receptor which is under development by Naurex as adjunctive therapy for treatment-resistant depression.

Cat. No.

A13729

CAS No.

130798-51-5

MDL 29951

MDL-29951 is a novel glycine antagonist of NMDA receptor activation (Ki=0.14 mM, [3H]glycine binding) in vitro and in vivo.

Cat. No.

A13882

CAS No.

2379-57-9

DNQX

DNQX is a non-N-methyl-D-aspartate (non-NMDA) receptor complex antagonist.

Cat. No.

A13946

CAS No.

19982-08-2

Memantine

Memantine is a noncompetitive antagonist of the N-methyl-D-aspartate receptor (NMDAR). It has been shown to modulate excitotoxicity and is utilized in research studies focused on moderate-to-severe Alzheimer's disease (AD). This compound is essential for exploring pathways related to neurodegeneration and cognitive function.

Cat. No.

A14071

NVP-AAM077 Tetrasodium Hydrate (PEAQX)

Synonyms: NVP,PEAQX; PEAQX

NVP-AAM077 inhibited progenitor cells proliferation in the subventricular zone and dentate gyrus and reduced the survival of newborn cells in the dentate gyrus in the adult mice.

Cat. No.

A15235

CAS No.

179411-94-0

SDZ 220-581 Ammonium salt

SDZ 220-581 ammonium salt is a potent, competitive antagonist at the NMDA glutamate receptor subtype(pKi= 7.7).

Cat. No.

A15522

CAS No.

142326-59-8

L-701324

L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor,

Cat. No.

A15523

CAS No.

486427-17-2

CIQ

CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.

Cat. No.

A15791

CAS No.

110347-85-8

CGS19755

CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylic acid) was found to be a potent, stereospecific inhibitor of N-methyl-D-aspartate (NMDA)-evoked, but not KCl-evoked, [3H] acetylcholine release from slices of the rat striatum.

Cat. No.

A16109

CAS No.

115066-14-3

CNQX

Synonyms: FG-9065

CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 uM for AMPA and kainate receptors, respectively, versus IC50 = 25 uM for NMDA receptors).

Cat. No.

A16583

CAS No.

23210-58-4

Ifenprodil tartrate

Ifenprodil tartrate is the atypical N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits NMDA-induced currents at NR1A/NR2B receptors with high affinity (IC50 = 0.34 μM).