Sigma Receptor | Adooq Bioscience

Cat. No.: A79296

CAS No.: 2088272-67-5

EST64454 maleate

EST64454 maleate is a potent σ1 receptor antagonist, effectively demonstrating antinociceptive properties suitable for pain management research. With excellent metabolic stability in various species and a favorable pharmacokinetic profile in rodent models, EST64454 maleate stands out as a promising candidate for clinical applications. Its high aqueous solubility and suitable permeability through Caco-2 cell membranes further support its potential in drug development studies.

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$65.00

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$150.00

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Cat. No.: A79298

CAS No.: 1335032-28-4

Sigma-1 receptor antagonist 6

Sigma-1 receptor antagonist 6 is a selective antagonist of the Sigma-1 receptor (σ1R), exhibiting significant antiallodynic properties. This compound effectively reduces mechanical allodynia in neuropathic pain models, particularly in response to paclitaxel treatment. Its application in research settings enables the exploration of σ1R modulation in pain pathways and the development of novel analgesic therapies.

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Cat. No.: A79305

CAS No.: 2573850-59-4

PW507

PW507 is a selective antagonist of the sigma 1 receptor (S1R) with a binding affinity of Ki 7.5 nM for the human variant. With minimal interactions with the sigma 2 receptor (S2R) and hERG channel, PW507 is well-suited for studies requiring brain penetration. This compound is particularly relevant for investigating painful diabetic neuropathy (PDN) and other related conditions.

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Cat. No.: A79311

CAS No.: 3026677-23-3

AB21

AB21 is a potent and selective antagonist of the sigma-1 receptor (S1R), exhibiting an IC50 value of 13 nM for S1R with minimal activity against the sigma-2 receptor (S2R) at 102 nM. This compound is effective in reducing mechanical hypersensitivity, making it a valuable tool for research into pain modulation and related neurological disorders. Additionally, AB21 may facilitate studies into the role of S1R in various physiological and pathological processes.

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Cat. No.: A79315

CAS No.: 138356-20-4

BD-1047

BD-1047 is a selective functional antagonist targeting sigma receptors. It demonstrates significant activity in modulating behaviors associated with dopamine signaling, reducing apomorphine-induced climbing and phencyclidine-induced head twitches. This compound is valuable for research applications in neuropharmacology and the study of sigma receptor biology.

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Cat. No.: A79324

CAS No.: 362512-81-0

σ1 Receptor antagonist 4

σ1 Receptor Antagonist 4 is a selective antagonist targeting the sigma1 (σ1) receptor, exhibiting a Ki value of 10 nM. This compound shows weak activity at the sigma2 (σ2) receptor with a Ki of 370 nM and demonstrates no significant effects on dopamine (DAT), serotonin (SERT), or norepinephrine (NET) transporters. σ1 Receptor Antagonist 4 is primarily utilized in research to elucidate the role of the σ1 receptor in various biological processes and its potential implications in neurodegenerative diseases and psychiatric disorders.

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