Drug Intermediate

Cat. No.

A50212

CAS No.

7384-89-6

L-erythro-Chloramphenicol

L-erythro-Chloramphenicol is a potent inhibitor of electron transport, primarily targeting mitochondrial function. Its significant biological activity makes it an important reagent in biochemical research relating to mitochondrial pathways and cellular respiration. This compound serves as a valuable intermediate in the synthesis of pharmaceutical agents and investigations involving antibiotic activity.

Cat. No.

A50636

CAS No.

893736-72-6

2'-Hydroxybiphenyl-3-carboxylic acid

2'-Hydroxybiphenyl-3-carboxylic acid serves as a β-lactamase OXA-48 inhibitor, with an IC50 value of 50 µM and a Kd of 1750 µM. This compound is primarily utilized as a drug intermediate in the synthesis of therapeutics targeting antibiotic resistance. Its inhibitory properties make it valuable in studying the mechanisms and effects of β-lactamase enzymes in various biological contexts.

Cat. No.

A51260

CAS No.

1477-50-5

Indole-2-carboxylic acid

Indole-2-carboxylic acid is an inhibitor of lipid peroxidation, functioning as a competitive antagonist of the glycine site on the NMDA receptor, with a Ki value of 15 μM. It selectively interrupts the enhancement of NMDA receptor activity by blocking glycine binding, which is crucial in various neurological disorders. Additionally, Indole-2-carboxylic acid inhibits the strand transfer activity of HIV-1 integrase by chelating magnesium ions at the enzyme's active site, allowing for impactful research applications in both neurobiology and virology.

Cat. No.

A53865

CAS No.

1818292-01-1

MDM2-p53-IN-19

MDM2-p53-IN-19 is a chemical intermediate designed to facilitate the synthesis of inhibitors targeting the MDM2-p53 interaction. This compound plays a critical role in the development of potential anticancer therapeutics by disrupting the MDM2-mediated inhibition of p53, a vital tumor suppressor. It is applicable in research focused on cancer biology and the development of novel cancer treatments.

Cat. No.

A69690

CAS No.

102029-44-7

(R)-4-Benzyl-2-oxazolidinone

(R)-4-Benzyl-2-oxazolidinone is a chiral oxazolidinone auxiliary that facilitates highly stereoselective asymmetric alkylation reactions. This compound is utilized in the total synthesis of natural products and pharmaceutical compounds, particularly as a key precursor for aromatase inhibitors. Its role is significant in research addressing estrogen-dependent breast cancer and other related areas in pharmaceutical development.

Cat. No.

A70147

CAS No.

1472616-61-7

DP-1

DP-1 is a degradation product of SDC-TRAP-0063 and serves as a fragment of Ganetespib, a potent inhibitor of heat shock protein 90 (HSP90). This compound exhibits significant anti-tumor activity, making it a valuable tool in cancer research. DP-1 can be utilized to elucidate the mechanisms of HSP90 inhibition and its implications in tumor biology.

Cat. No.

A70598

CAS No.

1472616-35-5

DP-1 hydrochloride

DP-1 hydrochloride is a degradation product of SDC-TRAP-0063 and functions as a fragment of Ganetespib. It acts as a heat shock protein 90 (HSP90) inhibitor, demonstrating significant anti-tumor activity. This compound is valuable for research applications focused on cancer biology and mechanisms of HSP90-related modulation in tumor cells.

Cat. No.

A87573

CAS No.

26218-75-7

Methyl 6-bromopicolinate

Methyl 6-bromopicolinate is a synthetic intermediate primarily utilized in the development of γ-secretase inhibitor library scaffolds. This compound plays a crucial role in medicinal chemistry, particularly in the design and synthesis of potential therapeutics targeting Alzheimer's disease through γ-secretase modulation. Its structural characteristics make it a valuable reagent for researchers exploring innovative drug candidates.

Cat. No.

A87606

CAS No.

272-49-1

4-Azaindole

4-Azaindole serves as a versatile scaffold in chemical research, particularly in the synthesis of Nav1.2 channel inhibitors. This compound exhibits significant biological activity, making it a candidate for investigations related to epilepsy and breast cancer. Its structural properties facilitate the development of targeted therapeutics in these areas of study.

Cat. No.

A88222

CAS No.

5909-24-0

Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate

Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate is a versatile drug intermediate that facilitates the synthesis of kinase inhibitors targeting Cdk4, PDGF, FGF, and EGF pathways. This compound exhibits significant potential in medicinal chemistry and pharmaceutical research, contributing to the development of therapies aimed at regulating cell proliferation and differentiation. Its structural versatility makes it a valuable building block for the design of innovative drug candidates.

Cat. No.

A95035

CAS No.

2170836-14-1

(1R,2S)-Xeruborbactam disodium

(1R,2S)-Xeruborbactam disodium is a boronic acid derivative that acts as a beta-lactamase inhibitor. This compound effectively enhances the activity of beta-lactam antibiotics against resistant bacterial strains, making it valuable for research into antibiotic resistance mechanisms. It has applications in studying bacterial enzyme inhibition and developing novel therapeutic strategies.

Cat. No.

A97788

CAS No.

27489-62-9

4-trans-Hydroxycyclohexylamine

Synonyms: trans-4-Aminocyclohexan-1-ol

4-trans-Hydroxycyclohexylamine is an important synthetic intermediate used in the development of norepinephrine transporter inhibitors. Its structural properties make it valuable in research focused on mood and behavior-related disorders. Applications of this compound extend to studies investigating the neurochemical pathways associated with these conditions.

Cat. No.

A97856

CAS No.

637-88-7

1,4-Cyclohexanedione

1,4-Cyclohexanedione serves as a crucial drug intermediate due to its role as a substrate for the EryKR1 domain. This compound exhibits unique biocatalytic activity and stereospecificity, making it valuable for various synthetic applications in pharmaceutical research. Its ability to participate in stereochemical transformations further supports its utility in the development of complex organic molecules.

Cat. No.

A97980

CAS No.

212321-78-3

BIBR 1087 SE

Synonyms: Desethyl Dabigatran Etexilate

BIBR 1087 SE is a key intermediate metabolite of dabigatran etexilate, functioning primarily as a reversible direct thrombin inhibitor. This compound plays a significant role in anticoagulant research, facilitating studies on blood coagulation pathways and thrombotic disorders. Its utilization in drug development is valuable for the creation of novel therapeutic agents targeting thrombin.

Cat. No.

A98272

CAS No.

2419904-59-7

Desmethyl nevanimibe

Desmethyl nevanimibe is a drug intermediate and a demethyl precursor of the sterol O-acyltransferase 1 (SOAT1) inhibitor Nevanimibe (PD-132301). This compound plays a critical role in the synthesis of SOAT1 inhibitors, which are of interest in the study of lipid metabolism and associated diseases. Research applications include investigations into cholesterol metabolism and the potential therapeutic effects in treating metabolic disorders.

Cat. No.

A98382

CAS No.

498-62-4

3-Thiophenecarboxaldehyde

Synonyms: 3-TC

3-Thiophenecarboxaldehyde is a thiophene derivative that serves as a substrate for biocatalytic reduction to 3-thiophenemethanol, facilitated by Pseudomonas putida S12 cells. This compound functions as an important intermediate in synthetic pathways. However, it exhibits toxicity toward Pseudomonas putida S12 at elevated concentrations, negatively impacting specific growth rates and final biomass yields. Its unique properties make it useful for research in biocatalysis and metabolic engineering.

Cat. No.

A98838

CAS No.

174264-46-1

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is a silyl ether derivative of Raloxifene formed through its reaction with tert-butyldimethylsilyl chloride. This compound plays a crucial role in the synthesis of Raloxifene 6-glucuronide, facilitating studies on Raloxifene metabolism and pharmacokinetics. Its utility in chemical research underscores its significance in the exploration of selective estrogen receptor modulators and their applications in therapeutic contexts.

Cat. No.

A99516

CAS No.

98960-08-8

3-Methoxy-4-(methoxymethoxy)aniline

3-Methoxy-4-(methoxymethoxy)aniline serves as a key pharmaceutical intermediate with applications in the synthesis of histone deacetylase (HDAC) inhibitors. This compound's structure facilitates the development of various bioactive molecules, enabling the exploration of therapeutic strategies in cancer and other diseases associated with epigenetic regulation. Its role in drug discovery makes it an important reagent for researchers focused on epigenetic therapies.

Cat. No.

B10424

CAS No.

863238-52-2

Sal-AMP

Sal-AMP is an acyl-adenylate intermediate that serves as a substrate for MbtA, facilitating the loading onto the thiolation domain of MbtB. This compound plays a critical role in the biosynthetic pathway of mycobacterial compounds and is valuable for research investigating tuberculosis and related bacterial processes. Its use can aid in understanding the mechanisms of mycobacterial metabolism and potential drug targets.

Cat. No.

B21654

CAS No.

837-52-5

7-Chloro-4-(piperazin-1-yl)quinoline

7-Chloro-4-(piperazin-1-yl)quinoline is a versatile chemical scaffold utilized in medicinal chemistry, primarily as a potent inhibitor of sirtuins. Additionally, it demonstrates significant inhibition of serotonin uptake with an IC50 of 50 μM. This compound exhibits notable antimalarial activity against D10 and K1 strains of Plasmodium falciparum, with IC50 values of 1.18 μM and 0.97 μM, respectively, making it a valuable tool for malaria research and drug development.

Cat. No.

B21764

CAS No.

87-41-2

Phthalide

Phthalide is a versatile chemical scaffold known for its potential in synthesizing various derivatives with significant biological activities. Its derivatives have been explored for applications as anti-inflammatory agents, antimicrobial compounds, antioxidants, and modulators of the blood-tumor barrier. Phthalide serves as a foundational structure in medicinal chemistry, facilitating the development of novel therapeutic agents.