Catalog No.
Product Name
Application
Product Information
Citations
- Hexapeptide-12isa bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient.
- Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM.
- Insulin receptor (1142-1153), pTyr1150 is a biological active peptide. (Peptide used as insulin receptor tyrosine kinase substrate.)
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GnRH peptide agonist
Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor. It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells. -
Tripeptide
RGD Trifluoroacetate is a tripeptide that specifically interacts with integrins to promote cell adhesion. This compound is instrumental in studying cellular processes related to adhesion and migration, making it valuable for research in cancer, tissue engineering, and regenerative medicine. Its ability to elicit specific cellular responses makes it a crucial tool for elucidating integrin-mediated pathways. -
Cell-Penetrating Peptide
Cys-Penetratin is a cell-penetrating peptide (CPP) characterized by the sequence CRQIKIWFQNRRMKWKK. This peptide facilitates the translocation of various biomolecules across cellular membranes, enhancing their delivery into living cells. Cys-Penetratin is widely used in research applications focused on drug delivery, gene therapy, and intracellular protein transportation. Its ability to efficiently transport cargo makes it a valuable tool in cellular and molecular biology studies. -
Anti-aging Peptide
Acetyltetrapeptide 11 is a bioactive peptide recognized for its anti-aging properties. It functions by promoting collagen synthesis and enhancing skin elasticity, making it valuable in cosmetic formulations aimed at reducing signs of aging. Its application extends to skincare products where it aids in rejuvenating and revitalizing the skin. -
Neuroactive Peptide
Gly-Pro-Glu is a neuroactive peptide that significantly influences acetylcholine release. As the N-terminal tripeptide of insulin-like growth factor-I, it effectively inhibits glutamate binding to the N-methyl-D-aspartate (NMDA) receptor, exhibiting an IC50 of 14.7 μM. This compound is valuable for research focused on neuroprotection and the modulation of neurophysiological processes. -
NK2/NK3 Receptor Agonist
Eledoisin is a specific agonist of the NK2 and NK3 receptors. This bioactive peptide exhibits significant biological activity in modulating neurokinin pathways, making it valuable in the study of pain and inflammatory responses. Eledoisin is utilized in research applications related to neurobiology and pharmacology, particularly in the exploration of neurokinin receptor signaling and its implications in various physiological processes. -
CD13 Receptor-binding Peptide
NGR peptide is a receptor-binding peptide that targets the aminopeptidase N (APN/CD13). This peptide demonstrates specific binding to CD13, facilitating its use as a key element in imaging applications. By conjugating NGR peptide to imaging agents, it allows for enhanced visualization of tumor sites, making it a valuable tool in cancer research and diagnostics. -
Synthetic Peptide Substrate
Ac-VETD-AMC is a synthetic peptide substrate specifically designed for the enzyme caspase 8. This compound enables the assessment of caspase activity, making it a valuable tool in apoptosis research. Additionally, Ac-VETD-AMC has the potential to evaluate the functional activity of recombinant phytaspase, contributing to studies in cell signaling and programmed cell death. -
Antimicrobial Peptide
Periplanetasin-4 is an antimicrobial peptide derived from the American cockroach (Periplaneta americana) that targets microbial pathogens. This peptide exhibits significant biological activities, including the reduction of cell rounding and apoptosis, while also inhibiting Clostridium difficile toxin A-induced reactive oxygen species (ROS) production. Periplanetasin-4 enhances mitochondrial calcium levels and mitigates vacuolar dysfunction in Candida albicans, highlighting its potential in antifungal research. Additionally, it demonstrates protective effects against toxin A-induced mucosal damage in mouse models, making it a valuable reagent for studies on colitis and intestinal health. -
Three Amino Acid Peptide
GPR is a three amino acid peptide that targets apoptosis pathways by inhibiting caspase-3/p53 dependent mechanisms. It demonstrates protective effects against amyloid beta (Aβ)-induced neuronal cell death in cultured rat hippocampal neurons. GPR is valuable for research related to Alzheimer's disease and studies focused on neuroprotection and cellular survival. -
T1/ST2 Receptor Ligand
d-T101 peptide is an important ligand for the T1/ST2 receptor, primarily involved in mediating apoptosis through the activation of caspases 3, 8, and 9, along with JNKinase and p38 MAPKinase pathways. This peptide exhibits significant immunostimulatory and anticancer properties by selectively inducing apoptosis in proliferating cancer cells. It enhances the expression of interleukin-2 (IL-2) and interferon-gamma (IFN-γ), as well as promoting the recruitment of natural killer (NK) cells and M1 macrophages to tumor sites. d-T101 peptide is invaluable for research in cancer immunotherapy and the modulation of immune responses. -
Smac-N7 Peptide
Smac-N7 peptide is derived from the N-terminal region of the mitochondrial protein Smac, a known activator of caspases. This peptide primarily targets and enhances apoptotic signaling pathways by promoting caspase activation, thereby facilitating programmed cell death. Due to its inability to penetrate cell membranes, Smac-N7 is useful for studying the mechanisms of apoptosis and can serve as a potent tool in cancer research and therapeutic development focused on apoptotic modulation. -
CD206 Targeting Peptide
RP-182 is a synthetic immunomodulatory peptide that targets the mannose receptor CD206 on tumor-associated macrophages (TAMs), exhibiting a dissociation constant (Kd) of 8 μM. By inducing a conformational change in the CD206 receptor, RP-182 activates NF-κB signaling, promoting TNFα secretion and phagocytosis in CD206high TAMs, ultimately leading to apoptosis via caspase 8 activation. This compound is valuable for research in pancreatic cancer and melanoma, providing insights into therapeutic strategies that enhance anti-tumor immunity. -
Proapoptotic Peptide
d-KLA Peptide is a synthetic pro-apoptotic peptide that specifically targets mitochondria to induce apoptosis by permeabilizing the mitochondrial membrane. This compound activates essential biochemical pathways associated with apoptosis, including the activation of caspase family proteins and poly ADP ribose polymerase (PARP). d-KLA Peptide is valuable for research applications focused on cancer therapeutics, particularly in enhancing anti-tumor effects through gene or small molecule delivery. -
AnxA2 inhibitor
LCKLSL is an N-terminal hexapeptide that functions as a competitive inhibitor of annexin A2 (AnxA2). It effectively blocks the interaction between tissue plasminogen activator (tPA) and AnxA2, thereby inhibiting plasmin generation. Through suppression of the tPA–AnxA2–plasmin pathway, LCKLSL exhibits significant anti-angiogenic activity and may serve as a valuable tool for studying AnxA2-mediated fibrinolytic and vascular processes. - ATWLPPR peptide is a biologically active heptapeptide and a specific antagonist of VEGFR2 (KDR/Flk-1). It binds to VEGFR2, completely blocking VEGF binding and thereby inhibiting VEGF-induced angiogenesis in vivo. ATWLPPR selectively inhibits human endothelial cell proliferation in vitro and fully suppresses VEGF-mediated angiogenesis in vivo.
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C1q/MBL inhibitor
PIC1 PA is a 15-amino-acid peptide and a potent analog of PIC1 that inhibits classical pathway–mediated complement activation. It functions by disrupting the interaction between C1s-C1r-C1r-C1s/MASPs and the collagen-like region (CLR) of C1q or MBL. PIC1 PA specifically binds to the CLR of C1q, with a mean equilibrium dissociation constant (K\_D) of 33.3 nM for purified C1q. -
NRP-1 targeting peptide
tLyP-1 peptide is a neuropilin-1 (NRP-1) targeting peptide with an IC₅₀ of 4 μM and the amino acid sequence CGNKRTR. It specifically binds to NRP-1, enabling selective targeting of tumor cells. -
CRF2 receptor agonist
Urocortin, human, is a 40-amino acid neuropeptide that functions as a selective agonist of the endogenous corticotropin-releasing factor receptor 2 (CRF₂). It exhibits high binding affinity with Kᵢ values of 0.4 nM for human CRF₁, 0.3 nM for rat CRF₂α, and 0.5 nM for mouse CRF₂β. Urocortin plays a role in modulating stress responses, cardiovascular function, and feeding behavior. -
CMKLR1 Agonist
Chemerin-9 (149–157) TFA is a potent peptide agonist of chemokine-like receptor 1 (CMKLR1), exhibiting significant anti-inflammatory activity. It activates downstream signaling pathways by stimulating the phosphorylation of Akt and ERK and promoting reactive oxygen species (ROS) production. Chemerin-9 (149–157) TFA has demonstrated neuroprotective effects, including the amelioration of Aβ₁₋₄₂-induced memory impairment in Alzheimer's disease models. Additionally, it plays important roles in modulating immune responses, regulating adipocyte differentiation, and improving glucose metabolism, making it a valuable tool for research in inflammation, neurodegeneration, and metabolic disorders. -
KRAS/ERK/RAS Inhibitor
LUNA18 is an orally bioavailable cyclic peptide that functions as a dual inhibitor of KRAS and ERK signaling pathways. It disrupts the interaction between RAS and guanine nucleotide exchange factors (GEFs), effectively inhibiting RAS activation and downstream signaling. In RAS-mutated cancer cells, LUNA18 reduces cell proliferation while modulating key signaling nodes, including phosphorylation of ERK and AKT. In preclinical studies, LUNA18 demonstrates potent anticancer activity, particularly in xenograft models, by blocking RAS-driven tumor growth. It shows significant cellular efficacy against cancer cell lines harboring KRAS mutations, including colon, gastric, pancreatic, and non-small cell lung cancers, highlighting its therapeutic potential as a targeted agent for RAS-driven malignancies. -
ERK1/2 activator
mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable peptide that functions as an activator of ERK1/2 signaling, with an EC₅₀ of 2.5–5 μM. It disrupts the interaction between the G-protein α and βγ subunits, promoting dissociation of the α subunit independently of nucleotide exchange. By modulating G-protein signaling, mSIRK enables selective activation of downstream pathways, such as ERK1/2, and serves as a valuable tool for studying G-protein–mediated signal transduction and ERK pathway activation. - Angiogenin Fragment (108–123) is a C-terminal peptide segment of Angiogenin that functions as an inhibitor of its enzymatic and biological activities. This fragment interferes with Angiogenin’s pro-angiogenic functions, making it a useful tool for studying angiogenesis and exploring therapeutic strategies targeting vascular growth.
- Tau Peptide (306–317) is a synthetic polypeptide fragment identified through peptide screening, a research technique that pools and evaluates active peptides—primarily via immunoassays. Peptide screening is widely used for studying protein–protein interactions, functional analysis, and epitope mapping, making Tau Peptide (306–317) a valuable tool in the research and development of therapeutic agents, particularly in neurodegenerative disease studies.
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Insulin Secretion Stimulator
GIP Human (Gastric Inhibitory Polypeptide) is a 42-amino acid peptide hormone that functions as an incretin. Secreted by intestinal K cells in response to nutrient ingestion, GIP enhances glucose-dependent insulin secretion and acts as a weak inhibitor of gastric acid secretion. It plays a key role in glucose homeostasis and metabolic regulation. -
Bone resorption inhibitor
Chicken calcitonin is a peptide hormone involved in the regulation of calcium metabolism. It inhibits bone resorption by suppressing the motility and activity of osteoclasts, as demonstrated in neonatal rat models. This hormone plays a key role in maintaining bone homeostasis and is of interest in bone-related research. - The Italian mutation of β-amyloid 1-40 (E22K) exhibits faster aggregation kinetics and greater neurotoxicity compared to the wild-type peptide. Solid-state NMR studies (Masuda et al.) suggest this enhanced toxicity may be linked to the formation of a salt bridge between Lys²² and Asp²³ in a minor conformer. Similar to the Arctic, Flemish, and Dutch Aβ variants, the Italian mutant also shows significantly reduced degradation by the Aβ-cleaving enzyme neprilysin, contributing to its pathological accumulation.
- Retrocyclin-101 is a synthetic antimicrobial peptide that exhibits broad-spectrum activity against both bacterial and viral pathogens. It functions by disrupting microbial membranes and enhancing host immune responses, making it a valuable candidate for infectious disease research and therapeutic development.
- Tetrapeptide-21 is a bioactive peptide commonly used in cosmetic formulations for its anti-wrinkle and skin-brightening properties. It promotes collagen synthesis and helps reduce the appearance of fine lines and hyperpigmentation, contributing to improved skin texture and tone.
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bioactive peptide
Acetyl tetrapeptide-9 is a bioactive peptide that promotes the synthesis of collagen I and stimulates the production of lumican, a key polysaccharide component of the basement membrane. It is commonly used in skin research and cosmetic formulations for its potential to enhance dermal structure and improve skin firmness. -
HOX/PBX interaction antagonist
HXR9 is a cell-permeable peptide that functions as a competitive antagonist of the HOX/PBX interaction, disrupting the binding of HOX proteins (paralogues 1–8) to the transcription factor PBX. It selectively inhibits proliferation and induces apoptosis in cells with elevated HOXA/PBX3 expression, such as MLL-rearranged leukemic cells, making it a valuable tool for studying HOX/PBX-driven oncogenesis. -
GLP-2R agonist
Glepaglutide (ZP1848) is a long-acting glucagon-like peptide-2 (GLP-2) analogue and a potent agonist of the GLP-2 receptor (GLP-2R). It enhances intestinal absorption, reduces faecal output, and alleviates small intestinal inflammation. Glepaglutide is a valuable agent for research in inflammatory bowel disease (IBD), including Crohn’s disease. -
Negative Control Peptide
PTD (Antennapedia leader peptide) serves as a negative control for the TRAF6 inhibitor peptide DRQIKIWFQNRRMKWKK-RKIPTEDEY. By demonstrating a lack of inhibitory activity, PTD provides a reference point for experimental comparisons in studies involving TRAF6 modulation. Its application is crucial in validating the specificity and efficacy of TRAF6-targeted interventions in various biological research contexts. -
VGF Derived Peptide
LQEQ-19 (mouse, rat) is a VGF-derived peptide that activates the PI3K/Akt and MEK/ERK signaling pathways, stimulating the phosphorylation of Akt and ERK1/2. It exhibits neuroprotective effects, making it a valuable tool for investigating various neurological conditions. LQEQ-19 is widely used in research focused on neural regeneration and neurodegenerative diseases. -
Akt/SKG Substrate
Akt/SKG Substrate Peptide is a synthetic peptide specifically designed as a substrate for Akt/PKB. This peptide is selectively phosphorylated by Akt/PKB and does not undergo phosphorylation by p70S6K or MAPK1, making it an ideal tool for studying the Akt signaling pathway. Its specificity is valuable in research applications focused on cancer, metabolism, and neurological disorders associated with Akt dysregulation. -
Substrate Mimetic Peptide
GSK3β-peptide is a substrate mimetic peptide that targets glycogen synthase kinase 3-β (GSK3-β) by binding to its active site and simulating substrate behavior. This peptide serves as a crucial tool in the development of substrate mimetic inhibitors of Akt, offering potential applications in anticancer drug discovery and research. Its ability to engage with GSK3-β positions it as a valuable reagent for probing signaling pathways involved in cell proliferation and survival. -
Amino Acid Polypeptide Hormone Analogue
Sincalide ammonium is an amino acid polypeptide hormone analogue of cholecystokinin (CCK) that primarily targets gallbladder function. It is utilized in clinical settings for its ability to promote gallbladder contraction, thus facilitating the diagnosis of gallbladder and pancreatic disorders. By increasing bile secretion and causing the contraction of the gallbladder while relaxing the sphincter of Oddi, Sincalide ammonium aids in the efficient drainage of bile into the duodenum, making it a valuable tool in postevacuation cholecystography. -
Antimicrobial Peptide
Cathelicidin-PY is an antimicrobial peptide that targets and inhibits the TLR4 inflammatory response pathways activated by lipopolysaccharide (LPS). This peptide demonstrates significant antimicrobial and anti-inflammatory properties while exhibiting low cytotoxicity in RAW 264.7 cells. Cathelicidin-PY is suitable for research focused on antimicrobial and anti-inflammatory mechanisms. -
B-cell Maturation Antigen Peptide
BCMA72-80 is a HLA-A2-specific peptide derived from the B-cell maturation antigen (BCMA) that exhibits strong binding affinity to HLA-A2. This peptide is primarily utilized in research focused on multiple myeloma and other tumors expressing BCMA. Its application is significant in studying immune responses and developing immunotherapeutic approaches targeting BCMA in oncology. -
Restricted Peptide Antigen
Eps8 peptide 327 is an HLA-A*2402-restricted peptide antigen derived from the Eps8 protein. It exhibits potent antitumor activity through significant cytotoxicity, effectively inhibiting cancer cell proliferation and inducing apoptosis. Eps8 peptide 327 disrupts the EGFR signaling pathway by modulating downstream signals, including IL-2, TNF-α, and IFN-γ, while also interfering with the Eps8/EGFR interaction. Its efficacy has been demonstrated in HT-29 xenograft mouse models, where it significantly inhibits tumor growth. -
Anti-aging Peptide
Acetyl tetrapeptide-2 is an anti-aging peptide that enhances skin rejuvenation by stimulating structural components such as collagen and elastin. This bioactive compound has been shown to reduce the loss of thymic factors, thereby promoting improved cellular stiffness in human keratinocytes (HaCaT cells). Its applications extend to various skin care formulations aimed at combating signs of aging and improving skin resilience.
