E1 activating

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  1. PYR-41

    Catalog No. A13254
    Ubiquitin E1 Inhibitor
    PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Learn More
  2. N106

    Catalog No. A16183
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    SUMO-activating enzyme activator
    N106, activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Learn More
  3. 2-D08

    Catalog No. A16852
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    SUMO inhibitor
    2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays. Learn More
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    COH000

    Catalog No. A17122
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    SUMO E1 Inhibitor
    COH000 is a highly specific covalent allosteric SUMO E1 inhibitor with an IC50 of 0.2 μM for SUMOylation in vitro. Learn More

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