Caspase

Cat. No.

A13070

CAS No.

519055-62-0

Tasisulam (LY573636)

Synonyms: LY 573636

LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.

Cat. No.

A11090

CAS No.

315183-21-2

PAC-1

Synonyms: first procaspase activating compound

PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.

Cat. No.

A11944

CAS No.

79183-19-0

Apoptosis Activator 2

Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells

Cat. No.

A12293

CAS No.

108477-18-5

Ubiquitin Isopeptidase Inhibitor I, G5

Synonyms: NSC144303

Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

Cat. No.

A14474

CAS No.

39524-08-8

Asperosaponin VI

Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP?\2/p38 and ERK1/2 pathway. Asperosaponin ?? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB.

Cat. No.

A15291

CAS No.

210345-03-2

Ac-LEHD-AFC

Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.

Cat. No.

A15308

CAS No.

10129-56-3

PETCM

PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols.

Cat. No.

A15319

CAS No.

1135417-31-0

Ac-IEPD-AFC

Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.

Cat. No.

A19867

CAS No.

131359-24-5

2-HBA

2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

Cat. No.

A23146

CAS No.

149231-66-3

Ac-YVAD-pNA

Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes.

Cat. No.

A24189

CAS No.

781652-57-1

CDPPB

CDPPB is a selective, orally active allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It enhances AKT and ERK1/2 signaling and upregulates BDNF mRNA expression. CDPPB also inhibits caspase-3 activation and mitigates mitochondrial dysfunction, demonstrating therapeutic potential in improving cognitive impairment, depression, and Huntington’s disease.

Cat. No.

A25113

CAS No.

400727-81-3

Ac-LEVDGWK(Dnp)-NH2

Ac-LEVDGWK(Dnp)-NH2 is a synthetic substrate for Caspase-3, designed to facilitate the measurement of Caspase-3 enzymatic activity. Its use in research enables the study of apoptosis and cellular signaling pathways, providing insights into the role of Caspase-3 in various biological processes. This substrate can be employed in assays to quantify Caspase-3 activity in different biological samples.

Cat. No.

A25114

CAS No.

219137-91-4

Z-VAD-AMC

Z-VAD-AMC is a potent substrate for caspase-9, facilitating the study of apoptosis mechanisms. It exhibits high specificity for this caspase, enabling accurate monitoring of caspase activity in cellular assays. Researchers commonly utilize Z-VAD-AMC in studies focusing on programmed cell death, cellular stress responses, and therapeutic interventions targeting apoptotic pathways.

Cat. No.

A25127

CAS No.

220846-62-8

(Asp)2-Rhodamine 110

Synonyms: D2R; (D)2-Rhodamine 110

(Asp)2-Rhodamine 110 is a fluorescent substrate specifically designed for caspase activity detection. This compound is cleaved by active caspases, resulting in the release of a fluorescent signal that allows for real-time monitoring of apoptosis in various biological systems. It is widely utilized in research applications focused on cell death mechanisms and therapeutic interventions targeting apoptosis.

Cat. No.

A25129

CAS No.

189684-53-5

Ac-VDVAD-pNA

Ac-VDVAD-pNA is a specific substrate for caspase-2, designed to facilitate the assessment of caspase-2 activity in various biological samples. This reagent releases a chromogenic product upon cleavage by active caspase-2, making it useful for both in vitro and in vivo studies. It serves as a vital tool in research applications focused on apoptotic pathways and caspase-related signaling mechanisms.

Cat. No.

A25173

CAS No.

189275-74-9

Ac-Trp-Glu-His-Asp-AMC

Synonyms: AC-WEHD-AMC

Ac-Trp-Glu-His-Asp-AMC is a specific fluorogenic substrate designed for caspase-1 detection and activity measurement. This compound exhibits high sensitivity and selectivity for caspase-1, enabling the quantitative assessment of apoptotic processes and inflammatory pathways. Its application in fluorescence assays facilitates the study of caspase-1's role in various biological contexts, including immune responses and cell death mechanisms.

Cat. No.

A25188

CAS No.

348079-18-5

Z-IETD-pNA

Synonyms: Z-Ile-Glu-Thr-Asp-pNA

Z-IETD-pNA is a specific substrate for caspase-8 and granzyme B, designed for colorimetric detection. Upon hydrolysis by caspase-8, this compound releases para-nitroaniline (pNA), facilitating the measurement of enzyme activity. It is widely utilized in research applications focusing on apoptosis and immune responses, enabling the study of cell death mechanisms and the role of granzyme B in cytotoxicity.

Cat. No.

A25198

CAS No.

2623-22-5

15-Acetoxyscirpenol

15-Acetoxyscirpenol is a potent caspase activator that induces apoptosis through the activation of multiple caspases, with effects that are independent of caspase-3. This mycotoxin significantly inhibits the growth of Jurkat T cells in a dose-dependent manner. Its ability to modulate apoptosis makes it a valuable tool for research in cancer biology and cell signaling pathways.

Cat. No.

A25200

CAS No.

154564-23-5

Z-YVAD-pNA

Synonyms: Z-Tyr-Val-Ala-Asp-pNA

Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a substrate specifically designed for caspase-1 activity. This compound is pivotal in studying inflammation and cell death pathways, as it is cleaved by caspase-1 during the activation of inflammatory caspases. Z-YVAD-pNA serves as an essential tool in research focused on apoptosis, pyroptosis, and other caspase-related signaling mechanisms. Its use can aid in the development of therapeutic strategies targeting inflammatory diseases.

Cat. No.

A25210

CAS No.

2999724-54-6

Caspase-3 activator 3

Caspase-3 activator 3 is a potent inducer of apoptosis, specifically targeting caspase-3 in HL-60 and K562 leukemia cell lines. This compound demonstrates significant antileukemic activity, with IC50 values of 42.89 μM for HL-60 cells and 33.61 μM for K562 cells. It serves as an important tool for investigating apoptotic pathways and evaluating potential therapeutic strategies in leukemia research.

Cat. No.

A25212

CAS No.

210344-99-3

Ac-WEHD-AFC

Ac-WEHD-AFC is a fluorogenic substrate specifically designed for the detection of caspase-1 activity. This compound enables the quantitative measurement of caspase-1 enzymatic function, making it a valuable tool in studies related to tumorigenesis and inflammatory processes. Its sensitive fluorescence readout facilitates the assessment of caspase-1 involvement in various biological systems.

Cat. No.

A25307

CAS No.

189684-50-2

Ac-Asp-Glu-Val-Asp-pNA

Ac-Asp-Glu-Val-Asp-pNA is a specific substrate for caspase-3/7, facilitating the study of apoptosis and cellular signaling pathways. This peptidic compound is cleaved by caspase-3/7, resulting in the release of p-nitroaniline (pNA), which can be quantitatively measured. Its use is critical in research applications focused on understanding programmed cell death and evaluating the activity of caspases in various biological contexts.

Cat. No.

A25311

CAS No.

189684-52-4

Ac-VDQQD-pNA

Ac-VDQQD-pNA is a selective substrate for Caspase 2, designed to facilitate the study of caspase activity. Upon cleavage by Caspase 2, it yields a yellow chromophore, p-nitroaniline (pNA), which can be quantitatively measured. This reagent is ideal for research applications focused on apoptosis, cell signaling, and the functional characterization of caspases.

Cat. No.

A25314

CAS No.

2999724-52-4

Caspase-3 activator 2

Caspase-3 Activator 2 is a potent activator of caspase-3, a key executioner of apoptosis. This compound effectively induces apoptotic cell death in cancer cell lines, demonstrating cytotoxicity with IC50 values of 33.52 μM against HL-60 cells and 76.90 μM against K562 cells. Its applications are significant in cancer research, particularly in studies investigating apoptotic pathways and therapeutic interventions.

Cat. No.

A25326

CAS No.

189696-01-3

Mca-YVADAP-Lys(Dnp)-OH

Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate designed for the characterization of caspase-1 and angiotensin-converting enzyme 2 (ACE2) activity. This compound enables the detection of enzymatic activity through fluorescence, making it valuable for studies focused on apoptosis and cardiovascular signaling pathways. It is suitable for use in various assays aimed at exploring the roles of these enzymes in cellular processes and disease states.