MDM2

Cat. No.

A10657

CAS No.

548472-68-0

Nutlin-3

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

Cat. No.

A14118

CAS No.

1364488-67-4

YH239-EE

YH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer.

Cat. No.

A18712

CAS No.

2136247-12-4

MD-224

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.

Cat. No.

A11502

CAS No.

675576-97-3

Nutlin 3b

Synonyms: (+)-Nutlin-3

Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.

Cat. No.

A15440

CAS No.

1303607-60-4

MI-773

Synonyms: SAR405838

MI-773 is an orally available MDM2 antagonist with Ki of 0.88 nM.

Cat. No.

A18877

CAS No.

2249750-24-9

PROTAC MDM2 Degrader-4

PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

Cat. No.

A18883

CAS No.

2249750-23-8

PROTAC MDM2 Degrader-3

PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

Cat. No.

A18890

CAS No.

2249944-99-6

PROTAC MDM2 Degrader-2

PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

Cat. No.

A18897

CAS No.

2249944-98-5

PROTAC MDM2 Degrader-1

PROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

Cat. No.

A24731

CAS No.

2136246-72-3

MD-222

MD-222 is a first-in-class PROTAC degrader targeting MDM2. This compound contains ligands for both Cereblon and MDM2, facilitating the rapid degradation of MDM2 protein and subsequent activation of wild-type p53 in cellular contexts. Due to its mechanism of action, MD-222 exhibits notable anticancer properties, making it a valuable tool for research in cancer biology and therapeutic development.

Cat. No.

A33129

CAS No.

890090-75-2

(Rac)-Nutlin-3

Synonyms: (Rac)-Rebemadlin

(Rac)-Nutlin-3 is a potent antagonist of the murine double minute protein 2 (MDM2), with an IC50 of 90 nM. This compound effectively disrupts the interaction between MDM2 and p53, leading to stabilization of the p53 protein. Additionally, (Rac)-Nutlin-3 promotes cell autophagy and apoptosis, making it a valuable tool for investigating the roles of MDM2 in TP53 wild-type ovarian carcinomas and other related cancer research applications.

Cat. No.

A53811

CAS No.

3049076-98-1

YX-02-030

YX-02-030 is a PROTAC MDM2 degrader that effectively inhibits the MDM2-p53 interaction with an IC50 value of 63 nM, as well as the VHL-HIF1α binding, with an IC50 of 1.35 μM. By binding to MDM2, it recruits the VHL E3 ubiquitin ligase, promoting MDM2 degradation. This compound is particularly relevant in researching therapeutic strategies against p53 mutant or deleted triple-negative breast cancer (TNBC) cells.

Cat. No.

A53880

CAS No.

2415160-21-1

MD-265

MD-265 is a potent MDM2 degrader utilizing the PROTAC (PROteolysis TArgeting Chimeras) technology. It effectively promotes the degradation of MDM2, resulting in the reactivation of the p53 tumor suppressor pathway in cancer cells with wild-type p53. Preclinical studies demonstrate that MD-265 induces complete tumor regression and enhances long-term survival in leukemia models, making it a valuable tool for cancer research and therapeutic development.

Cat. No.

A53881

CAS No.

2368944-44-7

WB156

WB156 is a dual degrader targeting MDM2 and GSPT1, facilitating their degradation through the recruitment of Cereblon (CRBN) to the ubiquitin-proteasome pathway. This compound effectively induces ubiquitination, leading to a reduction in MDM2 and GSPT1 levels, which is valuable for investigating the role of these proteins in cancer biology. WB156 holds potential for research applications in various cancer types, including leukemia.

Cat. No.

A53898

CAS No.

908027-55-4

MI-219

MI-219 is an MDM2 antagonist with a Ki of 13.3 μM, specifically designed to disrupt the interaction between MDM2 and p53. This compound effectively inhibits the proliferation of FSCCL cells, demonstrated by an IC50 of 2.5 μM. MI-219 is suitable for research applications focused on cancer biology, particularly in studies exploring pathways related to tumor suppression and the p53 signaling axis.

Cat. No.

A53904

CAS No.

548472-58-8

Nutlin 1

Nutlin 1 is a potent MDM2 antagonist that reactivates the p53 pathway, playing a critical role in cell cycle regulation and apoptosis. With an IC50 of 0.26 μM, it effectively disrupts the MDM2-p53 interaction, promoting p53-mediated transcriptional activity. This compound is widely used in cancer research to explore the therapeutic potential of p53 reactivation in tumor cells.

Cat. No.

B10899

CAS No.

3049077-01-9

(4R,5S)-YX-02-030

(4R,5S)-YX-02-030 is a stereoisomer of YX-02-030, functioning as a PROTAC (Proteolysis Targeting Chimera) designed to promote the degradation of MDM2. This compound exhibits potent biological activity in disrupting MDM2-mediated degradation of p53, thereby enhancing p53 activity and providing insights into cancer therapy. Its application is particularly relevant in studies of tumor suppression and cellular signaling pathways involving MDM2 and p53 interactions.