Selection Antibiotics & Contamination Control

Cat. No.

A28036

CAS No.

1202017-46-6

Amphotericin B trihydrate

Amphotericin B trihydrate is a polyene antibiotic primarily targeting fungal cell membranes by binding to ergosterol, leading to cell membrane disruption and cell death. This compound exhibits broad-spectrum antifungal activity and is also effective against leishmaniasis, making it valuable in the study of fungal infections and parasitic diseases. Its unique mechanism of action allows for diverse research applications in microbiology and infectious disease studies.

Cat. No.

A37751

CAS No.

11006-33-0

Phleomycin

Phleomycin is a copper-dependent antibiotic known for its DNA-damaging properties. It exerts its biological activity by binding to DNA and generating reactive oxygen species (ROS) in the presence of reducing agents, leading to both single-strand and double-strand breaks. This compound is extensively utilized in cancer research, microbial genetic transformation, serving as a screening marker to enhance fungal transformation efficiency, and the study of DNA repair mechanisms.

Cat. No.

A46310

CAS No.

69-53-4

Ampicillin

Synonyms: D-(-)-α-Aminobenzylpenicillin

Ampicillin is a broad-spectrum beta-lactam antibiotic that targets bacterial cell wall synthesis by inhibiting penicillin-binding proteins. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a valuable reagent in microbiological research and antibiotic susceptibility testing. Ampicillin is commonly used to study bacterial resistance mechanisms and is also employed in molecular biology for the selection of recombinant plasmids in cloning applications.

Cat. No.

A46313

CAS No.

57-92-1

Streptomycin

Synonyms: Agrept; Agrimycin; Streptomycin A

Streptomycin is an aminoglycoside antibiotic primarily targeting bacterial protein synthesis by binding to ribosomal RNA. It exhibits potent activity against Mycobacterium tuberculosis, making it essential for tuberculosis research. In addition, Streptomycin demonstrates bactericidal properties against various bacterial infections and interferes with nucleic acid interactions. Furthermore, this compound acts as a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes, enabling its use in studies related to electrophysiological processes.

Cat. No.

A46330

CAS No.

49863-47-0

G-418

Synonyms: Geneticin; Antibiotic G-418

G-418 is an aminoglycoside antibiotic that inhibits protein synthesis by binding to the ribosomal subunits, affecting both eukaryotic and prokaryotic cells. Its potent antibacterial properties make it a valuable tool in research applications such as the selection and maintenance of genetically modified cells, allowing for the study of gene function and expression. G-418 is widely utilized in molecular biology and cell culture workflows.

Cat. No.

A46570

CAS No.

11031-11-1

Phleomycin D1

Synonyms: PLM D1

Phleomycin D1 is a glycopeptide antibiotic that targets DNA. It exerts its biological activity by binding to and cleaving DNA, leading to cell death. Additionally, Phleomycin D1 induces cell cycle arrest at the S phase, making it a valuable reagent for research applications in cancer biology and molecular genetics.

Cat. No.

A46658

CAS No.

4697-36-3

Carbenicillin

Carbenicillin is a semi-synthetic penicillin antibiotic that primarily targets gram-negative bacteria through the inhibition of cell wall synthesis. It exhibits broad-spectrum antibacterial activity and is characterized by its relatively low toxicity towards plant tissues. Carbenicillin is commonly utilized in microbiological research and clinical applications to study bacterial growth and resistance mechanisms.

Cat. No.

A46874

CAS No.

61-33-6

Penicillin G

Synonyms: Benzylpenicillin

Penicillin G is a potent penicillin antibiotic targeting bacterial cell wall synthesis. It exhibits strong antibacterial activity against a wide range of Gram-positive bacteria and Gram-negative cocci. This compound is commonly used in research to study bacterial infections and the mechanisms of antibiotic resistance.

Cat. No.

A88134

CAS No.

64013-70-3

Kanamycin disulfate

Synonyms: Kanamycin A disulfate

Kanamycin disulfate is an aminoglycoside antibiotic that primarily targets bacterial ribosomes, inhibiting protein synthesis. It exhibits broad-spectrum antibacterial activity, making it valuable in biochemical assays to assess microbial resistance and susceptibility. This reagent is commonly used in microbiological research and in assays requiring selective inhibition of protein synthesis in bacterial studies.

Cat. No.

B21556

CAS No.

53-79-2

Puromycin

Synonyms: CL13900

Puromycin is an aminoglycoside antibiotic that functions as a protein synthesis inhibitor through its action on bacterial ribosomes. By mimicking aminoacyl-tRNA, puromycin interferes with the elongation step of translation, leading to the premature termination of peptide chains. This compound is widely utilized in molecular biology studies, particularly in selection and maintenance of genetically modified cells, as well as in cancer research to elucidate apoptosis pathways.