Other Targets

Cat. No.

AT0196

Anti-LY6E Antibody (MLYE4489A)

Synonyms: RG-7841 antibody

The Anti-LY6E Antibody (MLYE4489A), also known as RG-7841, is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets the lymphocyte antigen 6 complex, locus E (Ly6E). This antibody is comprised of a human immunoglobulin G2 (huIgG2) heavy chain and a human kappa (huκ) light chain, with an estimated molecular weight of 150 kDa. For isotype control purposes, Human IgG2 kappa, Isotype Control is recommended. This product is essential for research focusing on the role of Ly6E in immune response and its potential implications in therapeutic interventions.

Cat. No.

AT0199

Anti-TLR7 Antibody

The Anti-TLR7 Antibody is a human monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting Toll-Like Receptor 7 (TLR7). This antibody is composed of a human IgG1 heavy chain and a human kappa light chain, with an estimated molecular weight of 145 kDa. For isotype control purposes, Human IgG1 kappa, Isotype Control is recommended. This product is essential for studies focusing on the role of TLR7 in immune response and its implications in autoimmune diseases and therapeutic interventions.

Cat. No.

AT0205

Anti-KIR2DL1/CD158a Antibody

Cat. No.

AT0208

Anti-ACVR2A Antibody (Ab-14E1)

Synonyms: Ab-14E1

The Anti-ACVR2A Antibody (Ab-14E1) is a recombinant human monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets the ACVR2A receptor, which plays a crucial role in the TGF-beta signaling pathway, influencing cellular processes such as proliferation and differentiation. This antibody is comprised of an IgG1 heavy chain and a human kappa (huκ) light chain, and has a molecular weight of approximately 150 kDa. For experimental control purposes, the Human IgG1 kappa, Isotype Control is recommended as an appropriate isotype control for this antibody. This product is essential for research in cellular signaling and regulatory mechanisms, particularly in the context of developmental biology and cancer research.

Cat. No.

AT0209

Anti-ADAM9 Antibody (MGA021)

Synonyms: IMGC-936 antibody

The Anti-ADAM9 Antibody (MGA021), also known as IMGC-936 antibody, is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. This antibody specifically targets the ADAM9 enzyme, a member of the disintegrin and metalloproteinase domain-containing protein family, which plays a crucial role in cellular signaling, adhesion, and migration. The Anti-ADAM9 Antibody (MGA021) is composed of a human immunoglobulin G1 (huIgG1) heavy chain and a human kappa (huκ) light chain, and has a predicted molecular weight of 147.62 kDa. For experimental control purposes, the Human IgG1 kappa, Isotype Control is recommended as a suitable isotype control for this antibody. This product is essential for researchers focusing on cancer biology, tissue remodeling, and inflammatory processes where ADAM9 is implicated.

Cat. No.

AT0213

CAS No.

1452387-69-7

Crotedumab

Synonyms: REGN1193; Anti-GCGR Reference Antibody (crotedumab

Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody engineered to selectively bind to and inhibit the glucagon receptor (GCGR). This antibody demonstrates a high affinity for GCGR with a dissociation constant (K_D) of 0.1 nM, indicating potent binding capability. Crotedumab is primarily utilized in diabetes research, where modulation of the glucagon receptor is implicated in glucose homeostasis and diabetic pathology.

Cat. No.

AT0220

Anti-ABCB5 Antibody

The Anti-ABCB5 Antibody is a human monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting the ATP-binding cassette sub-family B member 5 (ABCB5). This antibody is composed of a human IgG2 heavy chain and a human kappa light chain and exhibits a predicted molecular weight of 145 kDa. For isotype control purposes, the Human IgG1 kappa, Isotype Control is recommended. This antibody is ideal for research applications focused on the function and expression of ABCB5 in various biological systems.

Cat. No.

AT0221

VB1-050

VB1-050 is a human monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting the SLC2A8 protein. This antibody is structured with human IgG1 heavy chains and human kappa light chains, and exhibits a predicted molecular weight of approximately 150 kDa. For isotype control purposes, Human IgG1 kappa, Isotype Control is recommended. This antibody is suitable for use in various biochemical assays and research applications focusing on the role and function of the SLC2A8 protein.

Cat. No.

AT0226

CAS No.

1189541-98-7

Sarilumab

Synonyms: Anti-Human IL6Rα; Human Antibody

Sarilumab is a recombinant human monoclonal antibody of the immunoglobulin G1 subclass, specifically targeting the alpha subunit of the human interleukin-6 receptor (IL-6Rα). As an antagonist to IL-6, Sarilumab binds with high affinity to IL-6Rα, effectively inhibiting both cis and trans signaling pathways mediated by IL-6. This inhibition plays a crucial role in modulating inflammatory responses, making Sarilumab a valuable tool for investigating the pathophysiology and potential therapeutic interventions for rheumatoid arthritis.

Cat. No.

AT0229

Anti-TIM-1/KIM-1/CD365 Antibody (2.70.2)

Synonyms: CR014; CDX-014 antibody

The Anti-TIM-1/KIM-1/CD365 Antibody (clone 2.70.2) is a monoclonal antibody that specifically targets the TIM-1/KIM-1/CD365 antigen. This antibody is designed for the precise detection and characterization of the T cell immunoglobulin and mucin-domain containing-1 (TIM-1), also known as kidney injury molecule-1 (KIM-1) and CD365. It is widely utilized in research focused on immunology, renal injury, and cancer, due to its role in mediating cellular immune responses and its upregulation in damaged kidney cells. This product is suitable for a variety of applications including flow cytometry, Western blotting, and immunohistochemistry.

Cat. No.

AT0238

Anti-LY75/CD205 Antibody (MEN1309)

Synonyms: OBT076

The Anti-LY75/CD205 Antibody (MEN1309) is a recombinant human monoclonal antibody expressed in Chinese hamster ovary (CHO) cells. This antibody specifically targets LY75/CD205, also known as DEC-205, a receptor involved in antigen uptake and presentation in immune cells. The antibody is composed of a human IgG1 type heavy chain and a human kappa light chain, with a predicted molecular weight of 145.36 kDa. For research purposes, a Human IgG1 kappa Isotype Control is recommended for use in assay validation to differentiate specific from non-specific binding.

Cat. No.

AT0245

CAS No.

1062149-33-0

Enavatuzumab

Synonyms: PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab

Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody designed to selectively target the TNF-like weak inducer of apoptosis receptor (TWEAK receptor, TweakR). This receptor is naturally engaged by its ligand TWEAK (TNFRSF12A), which activates various cellular responses. By binding to TweakR, Enavatuzumab inhibits tumor proliferation through direct receptor signaling and promotes antibody-dependent cell-mediated cytotoxicity (ADCC). This antibody has demonstrated efficacy in recruiting and activating myeloid effector cells to eradicate tumor cells. Enavatuzumab has shown to inhibit the growth of a range of human TweakR-positive cancer cell lines and xenografts both in vitro and in vivo, marking it as a potent therapeutic agent in cancer research and treatment.

Cat. No.

AT0246

Anti-Albumin Antibody

Cat. No.

AT0252

CAS No.

2376132-27-1

Latozinemab

Synonyms: AL001

Latozinemab (AL001) is a recombinant human monoclonal antibody targeting Sortilin. It binds with high affinity to Sortilin, effectively inhibiting the interaction between the progranulin protein (PGRN) and the Sortilin receptor. This antibody is particularly relevant for research into mutations in the progranulin gene (GRN) that are implicated in the pathogenesis of Frontotemporal Dementia (FTD-GRN), offering potential insights into therapeutic interventions and disease mechanisms.

Cat. No.

AT0256

Anti-CDCP1/CD318 Antibody (38 E11)

Synonyms: 38 E11

Cat. No.

AT0257

Anti-MAGEC2/CT10 Antibody (LX-CT10.5)

The Anti-MAGEC2/CT10 Antibody (LX-CT10.5) is a chimeric mouse monoclonal antibody of the IgG2a, κ subtype, designed to specifically target human MAGEC2/CT10. For accurate isotype control in experimental procedures, it is recommended to use the Mouse IgG2a kappa, Isotype Control.

Cat. No.

AT0261

Anti-IGFBP2 Antibody (M14)

The Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody that exhibits high-affinity binding to insulin-like growth factor-binding protein 2 (IGFBP2). This antibody effectively inhibits the interaction between IGFBP2 and insulin-like growth factor 1 (IGF1), thereby blocking IGFBP2's biological activity. The Anti-IGFBP2 Antibody (M14) has been demonstrated to inhibit endothelial cell recruitment, a critical process in tumor angiogenesis and metastasis, thereby impeding the progression of human metastatic cancers. This product is pivotal for research focused on cancer biology, particularly in studies exploring mechanisms of tumor growth and metastasis.

Cat. No.

AT0265

Anti-Clusterin Antibody (AB-16B5)

Anti-Clusterin (AB-16B5) is a humanized IgG2 monoclonal antibody specifically designed to target clusterin, a key protein involved in the regulation of the epithelial to mesenchymal transition (EMT). This antibody functions as an inhibitor of EMT, a process frequently implicated in cancer progression and metastasis. Anti-Clusterin (AB-16B5) is primarily utilized in oncological research studies to explore clusterin's role in cancer biology and its potential as a therapeutic target.

Cat. No.

AT0272

CAS No.

2682847-53-4

Eurestobart

Eurestobart is a humanized IgG1 kappa monoclonal antibody specifically designed to target ectonucleoside triphosphate diphosphohydrolase (ENTPDase). This antibody is engineered for high specificity and affinity in binding to its antigen, making it suitable for a variety of research applications focusing on the role of ENTPDase in disease processes and therapeutic interventions.

Cat. No.

AT0288

CAS No.

2642078-60-0

Izeltabart

Izeltabart is a humanized antibody with high affinity for ADAM9, designed for use in antibody-drug conjugate (ADC) applications. This antibody facilitates the site-specific attachment of Maytansinoid-based DM21-C, a drug-linker conjugate, to create the ADC known as IMGC936. The DM21-C component consists of a Maytansinoid, which acts as a microtubule inhibitor, linked via a stable tripeptide. IMGC936 demonstrates pronounced cytotoxic effects on ADAM9-expressing human tumor cell lines and has shown significant antitumor efficacy in xenograft tumor models. This product is pivotal for research focused on targeted cancer therapies, particularly those exploring the therapeutic potential of ADCs in oncology.

Cat. No.

AT0293

CAS No.

2630946-41-5

Tarperprumig

Synonyms: ALXN-1820

Tarperprumig is a monoclonal antibody engineered to target both ALB (Albumin) and CFP (Complement Factor Properdin) through its unique composition of two linked heavy chain variable regions. This bifunctional antibody is designed for high specificity and affinity in binding to its target antigens, making it an ideal tool for research in protein interaction studies and immune response investigations.

Cat. No.

AT0296

Anti-CRTAM/CD355 Antibody

Cat. No.

AT0300

Anti-CD163 Antibody (OR2805)

Anti-CD163 (OR2805) is a human monoclonal antibody of the IgG1 subclass designed to specifically target CD163, also known as scavenger receptor cysteine-rich type 1 protein M130. This antibody exhibits potential immunomodulating and antineoplastic properties by selectively binding to CD163, which is prominently expressed on immunosuppressive tumor-associated macrophages (TAMs) within the tumor microenvironment (TME). By binding to CD163, Anti-CD163 (OR2805) effectively inhibits the interaction of CD163 with its natural ligands, thereby modulating the immunosuppressive activity of TAMs and potentially enhancing antitumor immune responses. This mechanism positions Anti-CD163 (OR2805) as a valuable tool for research in cancer immunology and therapeutic development.

Cat. No.

AT0302

ATN-658

ATN-658 is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically targeting PLAUR/uPAR/CD87. This antibody is composed of a muIgG1 heavy chain and a mκ light chain, with a molecular weight of approximately 145 kDa. For experimental control purposes, Mouse IgG1 kappa, Isotype Control is recommended.

Cat. No.

AT0304

Anti-SLC44A4 Antibody

Synonyms: ASG-5ME Antibody; AGS-5M2

The Anti-SLC44A4 Antibody, also known as ASG-5ME Antibody, specifically targets the SLC44A4 protein. This antibody is utilized in the development of the antibody-drug conjugate (ADC) ASG-5ME, offering potential applications in targeted cancer therapy research.