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Other Targets lists biosimilar antibodies whose targets fall outside the main groups or have few products. Examples include omalizumab and ligelizumab, which bind immunoglobulin E (IgE), and bimagrumab, which blocks activin type II receptors. Lirilumab targets killer-cell immunoglobulin-like receptors (KIRs) on natural killer cells. The group also includes antibodies to allergens, Wnt pathway receptors, proteases, transporters and intracellular proteins such as histones. Several fusion proteins and peptide conjugates are listed here as well, including the long-acting granulocyte colony-stimulating factor (G-CSF) analogs balugrastim and eflapegrastim.
Synonyms: AK-1967
Procizumab (AK-1967) is a humanized IgG1 monoclonal antibody specifically targeting dipeptidyl peptidase 3 (DPP3). This antibody is of particular interest for research into the pathophysiology and potential treatments of sepsis. For experimental control purposes, Human IgG1 kappa, Isotype Control is recommended.
Synonyms: MSC-1
Anti-LIF Antibody (MSC-1) is a recombinant human monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets leukemia inhibitory factor (LIF), a key player in regulating cell differentiation, proliferation, and survival. The antibody is composed of a human IgG1 heavy chain and a human kappa light chain, with a total predicted molecular weight of 146.6 kDa. For isotype control experiments, Human IgG1 kappa, Isotype Control is recommended. This product is ideal for use in research applications focusing on developmental biology, cancer research, and regenerative medicine.
Ozureprubart is a humanized IgG1κ monoclonal antibody specifically targeting IGHE. For experimental control purposes, it is recommended to use Human IgG1 kappa as the isotype control.
Synonyms: Anti-MMP9 Reference Antibody (andecaliximab
Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody specifically targeting matrix metalloproteinase 9 (MMP9). Demonstrating antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models, Andecaliximab is suitable for research applications focused on gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF). This antibody offers a valuable tool for investigating the role of MMP9 in tissue remodeling and fibrosis.
Synonyms: EOS-448; EOS884448; GSK4428859A
Belrestotug (EOS-448) is a human immunoglobulin G1 kappa (hIgG1 kappa) antibody that acts as an antagonist to TIGIT (VSIG9, VSTM3). This monoclonal antibody exhibits antineoplastic activity, targeting and modulating immune responses that are critical in the context of oncology research. Belrestotug is designed for the study of immune checkpoint pathways and their role in cancer immunotherapy.
Synonyms: MERS-2E6; MERS Antibody-2E6
The Anti-MERS-2E6 monoclonal antibody (MERS-2E6; MERS Antibody-2E6) is a human IgG1 isotype, expressed in CHO cells, designed to neutralize Middle East Respiratory Syndrome coronavirus (MERS-CoV). This antibody competitively inhibits the binding of the viral spike protein to its cellular receptor, CD26 (DPP4), effectively blocking the virus from entering host cells. This mechanism positions the Anti-MERS-2E6 mAb as a critical tool for research into viral pathogenesis and the development of therapeutic strategies against MERS-CoV.
Synonyms: TAK-701
TAK-701 is a humanized monoclonal antibody that targets human hepatocyte growth factor (HGF), exhibiting potential antineoplastic properties. This antibody is specifically designed to bind to HGF, a multifunctional cytokine involved in cell growth, motility, and morphogenesis of various tissues, with a particular focus on its role in tumorogenesis. TAK-701 has shown efficacy in reversing gefitinib resistance in non-small-cell lung cancer (NSCLC), suggesting its utility in enhancing response rates to conventional therapies in resistant cancer cells. This makes it a valuable tool for research in cancer treatment modalities, particularly in understanding and overcoming drug resistance mechanisms in NSCLC.
Synonyms: DS-6157 antibody
The Anti-GPR20 Antibody (DS-6157) is a recombinant human monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets the GPR20 receptor, a G protein-coupled receptor implicated in various physiological processes. This antibody is comprised of a human IgG1 type heavy chain and a human kappa (huκ) type light chain, exhibiting a predicted molecular weight of approximately 150 kDa. For experimental controls, the Human IgG1 kappa Isotype Control is recommended as a suitable reference.
Turigrobart is a human monoclonal antibody that specifically targets Epiregulin (EREG). This reagent exhibits significant activity in modulating EREG signaling pathways, making it a valuable tool for research on cancer biology and cellular signaling. Its application includes studying EREG's role in tumor progression and potential therapeutic interventions, highlighting its relevance in oncology and immunotherapy research.
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