Catalog No.
Product Name
Application
Product Information
Citations
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AhR antagonist
CHD-5 is a potent antagonist of the aryl hydrocarbon receptor (AhR). This compound effectively inhibits AhR-mediated signaling pathways, which are involved in various biological processes including cellular proliferation and immune responses. CHD-5 is valuable for researchers investigating the role of AhR in cancer biology, immunology, and toxicology. -
AhR Agonist
Corannulene is an agonist of the aryl hydrocarbon receptor (AhR), known for its ability to modulate cellular signaling pathways. This compound exhibits reduced cytotoxicity compared to Benzo[a]pyrene in hepatoma cells, making it a valuable tool in cancer research. Corannulene's unique properties may facilitate the exploration of AhR-related mechanisms in tumor biology and therapeutic interventions. -
hCYP1B1 Inhibitor
hCYP1B1-IN-2 is a highly selective inhibitor of the human cytochrome P450 1B1 enzyme (hCYP1B1). It demonstrates remarkable potency in inhibiting hCYP1B1 activity, with an IC50 value of 0.040 nM, alongside a Ki value of 21.71 pM, indicating effective mixed inhibition. This compound also effectively disrupts aryl hydrocarbon receptor (AhR) transcription activities, making it a valuable tool for research applications focused on cancer and toxicology. -
AHR Inhibitor
AHR-IN-1 is a selective aryl hydrocarbon receptor (AHR) inhibitor, exhibiting an IC50 of less than 0.5 μM. This compound is useful for investigating the role of AHR in various biological processes, including immune response modulation and xenobiotic metabolism. AHR-IN-1 serves as a valuable tool for researchers studying the mechanisms by which AHR influences cellular signaling and gene expression. -
AHR Antagonist
AHR Antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist with a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide structure, exhibiting an IC50 of 82.2 nM. This compound demonstrates significant anti-cancer properties, making it a valuable tool for research on cancer biology and therapeutic applications targeting AHR pathways. Its ability to modulate AHR signaling may offer insights into mechanisms driving tumor progression and potential treatment strategies. -
AhR Agonist
AhR Agonist 8 is a potent agonist of the Aryl Hydrocarbon Receptor (AhR) with an EC50 value of 0.154 nM. This compound serves as a valuable tool for investigating the biological processes linked to psoriasis and atopic dermatitis. Its high affinity and specificity make AhR Agonist 8 suitable for research applications targeting immune modulation and skin-related disorders. -
hCYP1B1 Inhibitor
CYP1B1-IN-10 is a potent and selective inhibitor of human cytochrome P450 1B1 (hCYP1B1), exhibiting an IC50 value of 0.11 μM. This compound plays a significant role in the investigation of hormone-dependent tumors, including breast and ovarian cancers. Its specificity makes it a valuable tool for studying the therapeutic potential in oncology research. -
AhR Agonist
AhR Agonist 6 is a potent agonist for the aryl hydrocarbon receptor (AhR), exhibiting an EC50 of 0.01 nM. This compound effectively activates AhR signaling pathways, making it valuable for investigating the receptor's role in toxicology, immune response, and cellular differentiation processes. Its high potency allows for precise modulation of AhR-related biological activities in various research applications. -
AhR Activator
3-OH-Kynurenamine is an aryl hydrocarbon receptor (AhR) activator that modulates immune responses. This compound enhances the expression of immune regulatory genes such as Ido1 and Tgfb1, demonstrating therapeutic potential in reducing skin inflammation in psoriasis mouse models, as well as alleviating kidney damage in nephrotoxic lupus mouse models. Its unique biological activity makes it valuable for research involving immune modulation and inflammatory diseases. -
AhR Agonist
AhR agonist 7 is a potent agonist of the aryl hydrocarbon receptor (AhR), exhibiting an EC50 value of 13 nM. This compound effectively activates AhR signaling pathways, making it valuable for research into toxicology, immunology, and cancer biology. AhR agonist 7 can be utilized to study the effects of AhR activation on gene expression and cellular responses. -
AHR Agonis
L-Kynurenine sulfate is an aryl hydrocarbon receptor (AHR) agonist that promotes AHR-mediated signaling pathways. It has been shown to stimulate the polarization of naive T cells towards the anti-inflammatory regulatory T cell (Treg) phenotype, enhancing immune tolerance mechanisms. This compound is valuable for research focused on immunology, inflammation, and therapeutic approaches in autoimmune diseases. -
CYP1A1 Inducer
1,2,3,4,7,8,9-Heptachlorodibenzofuran is a potent inducer of CYP1A1 and CYP1B1 gene expression in human peripheral blood lymphocytes, promoting aryl hydrocarbon receptor repressor (AhRR) transcription. This compound enhances ethoxyresorufin-O-deethylase (EROD) activity, serving as a reliable biomarker for CYP1A1 activation. Additionally, it displays immunosuppressive properties by decreasing the number of splenic plaque-forming cells in mice while increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes. 1,2,3,4,7,8,9-Heptachlorodibenzofuran is valuable for research in immunology, metabolic disorders, and environmental toxicology. -
CYP1A1/1B1 Activator
1,2,3,4,7,8-Hexachlorodibenzofuran is a selective activator of the CYP1A1 and CYP1B1 enzymes. It induces the expression of these cytochrome P450 enzymes and aryl hydrocarbon receptor repressor (AhRR) in human peripheral blood lymphocytes. This compound also stimulates ethoxyresorufin-O-deethylase activity, achieving approximately 20% of the response observed with TCDD at a BMR20TCDD of 0.115-0.143 nM. Its ability to modulate these pathways makes it a valuable tool for studying biological responses to environmental pollutants and the mechanisms of xenobiotic metabolism. -
AHR Activator
AhR modulator-2 is an AHR activator with an EC50 of 0.028 μM in HepG2-Lucia cells. This compound is valuable for investigating the role of the aryl hydrocarbon receptor (AHR) in various diseases, including skin disorders and cancer. Its ability to modulate AHR activity makes it a useful tool in the study of AHR-mediated signaling pathways and associated pathologies. -
Phenylurea Herbicide
Neburon is a phenylurea herbicide that primarily functions by inhibiting photosynthetic electron transport, leading to the disruption of algal growth. This compound activates the aryl hydrocarbon receptor (Ahr) and Notch1 signaling pathways, resulting in the induction of oxidative stress and apoptosis. Prolonged exposure has been associated with significant male reproductive toxicity and cardiotoxicity in zebrafish, making this reagent valuable for studies on environmental impact and toxicological assessments. -
AhR Agonist
Picoberin is a potent aryl hydrocarbon receptor (AhR) agonist that functions at low picomolar concentrations. It is known to inhibit Hedgehog-induced osteoblast differentiation and Wnt3A-induced osteoblast differentiation in C3H10T1/2 cells. Additionally, Picoberin has the ability to upregulate genes responsible for encoding phase I and II metabolic enzymes, making it a valuable reagent for research into cellular differentiation and metabolic processes. -
AHR Antagonist
AHR Antagonist 6 is an aryl hydrocarbon receptor (AHR) antagonist that inhibits AHR signaling pathways. This compound has demonstrated key biological activity in modulating immune responses and is utilized in cancer research to investigate the role of AHR in tumor microenvironments. Researchers can employ AHR Antagonist 6 to explore therapeutic strategies targeting AHR-mediated pathways in various cancer models. -
COX/5-LOX Inhibitor
Phenethyl ferulate is a potent inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), displaying IC50 values of 4.35 μM and 5.75 μM, respectively. This compound exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammation-related pathways. Its ability to modulate these key enzymes positions it as a promising candidate for studies focused on inflammatory diseases and therapeutic interventions. -
5-LOX/COX Inhibitor
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX), exhibiting IC50 values of 3.5 μM and 3.1 μM, respectively, in RBL-1 cells. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into inflammatory pathways and related diseases. Its dual inhibition of leukotriene and prostaglandin synthesis positions FPL 62064 as a pertinent reagent for studies focusing on inflammation and related therapeutic interventions. -
5-LO/COX Inhibitor
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) enzymes, exhibiting an IC50 of 5 μM for 5-LO. It also demonstrates inhibitory activity against COX-1 and COX-2, with IC50 values of 0.65 and 1.2 μg/mL, respectively. This compound is valuable for research applications involving inflammation and other related pathways. Its ability to concurrently inhibit key lipid mediators makes BW 755C a useful tool in studies focused on arachidonic acid metabolism and signaling pathways. -
COX-2/5-LOX Inhibitor
Tebufelone is a selective dual inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO). It exhibits significant anti-inflammatory, analgesic, and antipyretic properties, making it useful for research into inflammatory pathways. This compound is valuable for studying the roles of COX-2 and 5-LO in various biological processes and assessing novel therapeutic strategies for inflammatory diseases. -
Dual COX/5-LOX Inhibitor
ER-34122 is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LO). This compound exhibits significant anti-inflammatory activity, making it valuable for research into inflammation-related pathways. ER-34122 is particularly relevant for studies investigating the interplay between COX and 5-LO pathways in various disease models and therapeutic contexts. -
Endogenous Metabolite
C16-18:1 PC (1-O-Hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine) is an endogenous metabolite and a pro-inflammatory lipid mediator from the platelet-activating factor (PAF) family of glycerophospholipids. This compound exhibits diverse biological activities and plays a significant role in signaling pathways related to inflammation. C16-18:1 PC can be utilized in research applications involving lipid metabolism, cell signaling, and inflammatory processes, providing insights into the underlying mechanisms of various diseases. -
Anti-inflammatory Agent
trans-Isoferulic acid, an aromatic acid and potent anti-inflammatory agent, is derived from the roots of Clematis florida var. plena. It effectively inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by inducing Nrf2-dependent heme oxygenase-1 (HO-1). This compound is valuable for research applications focused on inflammation pathways and the modulation of oxidative stress. -
5-LO/PGE2 Inhibitor
Canniprene is a potent inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2), with IC50 values of 0.4 μM and 10 μM, respectively. Derived from Cannabis sativa, Canniprene modifies the biosynthesis of inflammatory eicosanoids and prostaglandins, making it a valuable tool for researching inflammation and related pathways. Its unique mechanism of action positions Canniprene as a potential candidate for studying inflammatory diseases and therapeutic interventions targeting lipid mediators. -
Phospholipase Activator
9-Oxononanoic acid is a potent phospholipase A2 (PLA2) activator that arises as a secondary product of lipid peroxidation. It stimulates the production of thromboxane A2 (TXA2) and promotes platelet aggregation in human blood, making it a valuable tool for studying platelet function and related cardiovascular processes. Its oral bioavailability enhances its utility in various in vivo research applications. -
TXA2/5-Lipoxygenase Inhibitor
CV-6504 is a dual inhibitor targeting thromboxane A2 (TXA2) synthase and 5-lipoxygenase. This compound demonstrates significant biological activity by scavenging reactive oxygen species (ROS) and exhibiting antitumor properties. CV-6504 is applicable in research focused on cancer, inflammation, and cardiovascular diseases, providing valuable insights into therapeutic strategies and molecular mechanisms. -
5-Lipoxygenase/Thromboxane Synthase Inhibitor
E 3040 is an orally active inhibitor of both 5-lipoxygenase and thromboxane synthase, key enzymes involved in inflammatory processes. This dual inhibition provides significant anti-inflammatory activity, making E 3040 a valuable reagent for research into inflammatory diseases and related pathways. Its unique mechanism can facilitate studies on the modulation of leukotrienes and thromboxanes in various biological contexts. -
Stable Isotope
trans-Isoferulic acid-d3 is a deuterium-labeled derivative of trans-Isoferulic acid, a naturally occurring aromatic acid derived from Clematis florida var. plena. This compound possesses notable anti-inflammatory properties, primarily through its ability to suppress nitric oxide (NO) and prostaglandin E2 (PGE2) production. Its mechanism of action involves the induction of Nrf2-dependent heme oxygenase-1 (HO-1), making it valuable for research into cellular stress responses and inflammation pathways. -
Endogenous metabolites
Prostaglandin F1β is a C-9 epimer of prostaglandin F1α, primarily targeting endogenous metabolites in biological systems. It is known to enhance respiratory rates in rabbits, making it valuable for research applications in respiratory physiology and metabolic regulation. Additionally, its role in various signaling pathways opens avenues for studying inflammatory processes and reproductive biology. -
PDE2 Inhibitor
ND-7001 is a potent inhibitor of phosphodiesterase 2 (PDE2) with an IC50 value of 0.05 μM, demonstrating significant selectivity against PDE3 and PDE4. This compound effectively elevates cGMP levels in primary neuronal cultures derived from rat cerebral cortical neurons, contributing to its role in modulating neuronal signaling. ND-7001 is primarily utilized in research focused on anxiety disorders and neuropharmacology, highlighting its potential for evaluating anxiolytic mechanisms. -
5-LO/TXA2 Inhibitor
E-6700 is a potent inhibitor of 5-lipoxygenase (5-LO) and thromboxane A2 (TXA2) synthetase, with IC50 values of 16.3 μM and 0.026 μM, respectively. This compound effectively inhibits the production of leukotriene B4 (LTB4) and thromboxane B2 (TXB2). E-6700 is suitable for applications in anti-inflammatory research, providing a valuable tool for investigating pathways associated with inflammatory responses. -
Endogenous metabolites
5-trans Prostaglandin F2β is an endogenous metabolite and a key isomer of 5-trans Prostaglandin F2α, specifically the 9β-hydroxy form. This compound plays a significant role in various physiological processes, including vasodilation and modulation of reproductive functions. Its primary applications include research in cardiovascular biology and reproductive health, providing valuable insights into prostaglandin signaling pathways and their effects on cellular responses. -
KRAS-PDEδ Interaction Inhibitor
Atrovastatin-PEG3-FITC is a KRAS-PDEδ interaction inhibitor that serves as a valuable tool in the study of KRAS signaling pathways. This compound can function as a ligand in fluorescence anisotropy assays, enabling researchers to investigate protein-protein interactions and their implications in cancer biology. Its application aids in understanding the role of KRAS in various malignancies and exploring potential therapeutic interventions. -
GAL2R Agonist
Galanin (2-29) (rat) is a selective GAL2R agonist with a Ki of 3.5 nM, exhibiting significant biological activity in modulating peptide secretion. This peptide has been shown to inhibit rat pancreatic protein and CCK-8-stimulated amylase secretion, making it a valuable tool for research on pancreatic function and gastrointestinal regulation. Applications include studies on neuroendocrine signaling and the investigation of galanin receptor pathways. -
Endogenous Metabolite
Kinetensin is an endogenous peptide that exhibits neurotensin-like properties. It has been isolated from pepsin-treated human plasma and functions as a neuromodulator, influencing various biological processes such as pain perception, neuroinflammation, and gastrointestinal functions. Kinetensin is utilized in research applications aimed at understanding neuropeptide signaling pathways and their implications in various physiological and pathological conditions. -
Sex Pheromone
(E)-8-Dodecenyl acetate is a sex pheromone that targets the olfactory receptors of male Gymnandrosoma aurantianum moths, acting as an agonist. This compound plays a significant role in the study of insect communication and behavior, making it valuable for research focused on agricultural pest management. Its unique mechanism offers potential insights into pest control strategies and the ecological impact of pheromones. -
Endogenous Metabolite
[Leu5]-Enkephalin TFA is a pentapeptide that functions as an agonist at opioid receptors. This endogenous metabolite exhibits morphine-like properties, playing a significant role in pain modulation and analgesic pathways. Its biological activity makes it valuable in research focused on opioid signaling and the development of pain management therapies. -
Muscarinic Receptor/Phospholipase C Activator
(S)-Albuterol is a selective muscarinic receptor agonist that acts as a phospholipase C activator. It is known to elevate intracellular free calcium levels in airway smooth muscle, enhancing muscle contraction. This compound is widely utilized in research applications focusing on airway physiology and the mechanisms underlying bronchoconstriction. -
Fungal Secondary Metabolite
Benzomalvin B is a fungal secondary metabolite that serves as a less active analog of Benzomalvin A. It exhibits weak activity against substance P, making it a compound of interest for research into neuropeptide signaling and related biological processes. Its properties may facilitate studies in pain modulation and the exploration of therapeutic avenues in neurobiology. -
Fungal Metabolite
Acetylaszonalenin is a prenylated indole derivative that acts as a neurokinin-1 (NK1) receptor antagonist. This fungal metabolite demonstrates significant inhibition of [3H]-substance P binding to human astrocytoma cells, with a Ki value of 170 μM. Acetylaszonalenin is applicable in research exploring neurokinin signaling and its role in neuroinflammation and related neurological disorders. -
5-LOX Inhibitor
5-O-Demethylnobiletin is an effective inhibitor of 5-lipoxygenase (5-LOX), exhibiting a potent IC50 of 0.1 μM without impacting COX-2 expression. This polymethoxyflavone, derived from Citrus jambhiri Lush., demonstrates notable anti-inflammatory properties by inhibiting leukotriene B4 (LTB4) production in rat neutrophils and elastase release in human neutrophils with an IC50 value of 0.35 μM. 5-O-Demethylnobiletin is valuable for research applications related to inflammation and leukotriene signaling pathways. -
5-LO Inhibitor
Enofelast (BI-L-239) is a selective inhibitor of 5-lipoxygenase (5-LO) with an IC50 of 2.48 μM, effectively blocking calcium ionophore-induced leukotriene B4 (LTB4) production. Its ability to modulate lipid mediators makes it a valuable tool for studying inflammatory pathways and leukotriene signaling in various biological contexts. Enofelast is suitable for research applications investigating the role of 5-LO in diseases associated with inflammation and immune response. -
PA2/5-LOX/COX Inhibitor
LY256548 is a potent inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and cyclooxygenase (COX), demonstrating significant anti-ischemic and anti-inflammatory properties. This compound effectively reduces leukotriene B4 production in response to A23187 stimulation. In preclinical models, LY256548 has shown efficacy in mitigating bone damage and paw swelling in rat models of Freund's complete adjuvant-induced arthritis (FCA), making it a valuable tool for research into inflammatory diseases and analgesic mechanisms. -
Cyclooxygenase/Lipoxygenase Inhibitor
L-652343 is a dual inhibitor of cyclooxygenase and lipoxygenase enzymes. It effectively inhibits the production of leukotriene B4 (LTB4) in isolated human polymorphonuclear leukocytes, demonstrating an IC50 value of 1.4 μM when challenged with Calcimycin. This compound is applicable in the study of inflammatory and immune diseases, providing insights into the mechanisms of these conditions and potential therapeutic interventions. -
5-LO Inhibitor
5-LOX-IN-6 is a potent and selective inhibitor of 5-lipoxygenase (5-LO), exhibiting reversible inhibition. It effectively reduces 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 µM and 0.086 µM, respectively. By inhibiting leukotriene biosynthesis, 5-LOX-IN-6 serves as a valuable tool in the study of inflammatory and allergic disorders. -
5-LOX Inhibitor
E 6080 is a specific inhibitor of 5-lipoxygenase (5-LOX), exhibiting an IC50 of 0.2 μM in rat basophilic leukemia cells. This compound effectively reduces leukotriene release, which is critical in the inflammatory response. E 6080 has demonstrated the ability to inhibit bronchospasm induced by antigen inhalation in sensitized guinea pigs, making it a valuable tool for asthma research and related inflammatory conditions. -
5-LOX Inhibitor
A63162 is a selective inhibitor of 5-lipoxygenase (5-LOX), a key enzyme in the biosynthesis of leukotrienes. This compound effectively inhibits both mitogen-induced proliferation of horse mononuclear cells and the synthesis of leukotriene LTB4 in response to Calcimycin at equivalent concentrations. A63162 is useful in research focused on chronic obstructive pulmonary disease, arthritis, and inflammatory bowel disease, offering insights into inflammatory pathways and potential therapeutic interventions. -
CETP Inhibitor
Obicetrapib is a potent cholesteryl ester transfer protein (CETP) inhibitor that effectively reduces atherogenic lipoproteins, including LDL-C, ApoB, and lipoprotein(a), while simultaneously increasing HDL-C levels. This compound is of significant interest in research related to dyslipidemia and atherosclerotic cardiovascular disease (ASCVD), facilitating investigations into lipid metabolism and cardiovascular health outcomes. -
Muscarinic Receptor/Phospholipase C Activator
(S)-Albuterol hydrochloride is a selective muscarinic receptor activator that enhances phospholipase C activity. This compound increases intracellular free calcium levels in airway smooth muscle, making it valuable for research on respiratory physiology and pharmacology. Its ability to modulate calcium signaling pathways makes it useful for studying smooth muscle contraction and respiratory function.
