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Carboxylesterase (CES)

Carboxylesterase (CES) inhibitors and substrates act on serine hydrolases that cleave ester bonds. Mammalian carboxylesterases hydrolyze endogenous esters and many ester-containing drugs and prodrugs, as a 1998 review summarized. Human CES1 is abundant in liver, whereas CES2 predominates in the small intestine. Nevadensin is a natural flavone reported to inhibit human carboxylesterase 1 (hCE1), and WZU-13 is a further carboxylesterase inhibitor. CEMT is listed as a carboxylesterase substrate with mitochondria-targeting properties. Carboxylesterase-IN-2 and Carboxylesterase-IN-3 inhibit Notum, a secreted carboxylesterase shown in 2015 to remove the palmitoleate group that Wnt proteins need for signaling. The set is mixed and also includes loperamide hydrochloride and tefinostat, whose main targets lie elsewhere.

1 Item

  • Loperamide hydrochloride
    Cat. No.
    A10536
    CAS No.
    34552-83-5

    Loperamide hydrochloride

    Synonyms: R-18553 hydrochloride

    Loperamide hydrochloride is an opioid receptor agonist that functions primarily as an autophagy inducer. This compound selectively inhibits human intestinal carboxylesterases (hiCE), contributing to its anti-diarrheal properties. Its unique mechanism of action makes Loperamide hydrochloride a valuable reagent for studies related to gastrointestinal motility and autophagy modulation in various biological contexts.

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    50 mg
    $30.00
    100 mg
    $40.00
    All 4 sizes

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