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PDE

Phosphodiesterase (PDE) inhibitors prevent the hydrolysis of cyclic nucleotides, second messengers of many receptors. The PDE superfamily comprises 11 families, PDE1 to PDE11, which differ in substrate preference, regulation and tissue distribution. Some families hydrolyze cyclic adenosine monophosphate (cAMP), others cyclic guanosine monophosphate (cGMP), and several act on both. By controlling the amplitude and location of these signals, PDEs shape inflammation, smooth muscle tone and cardiac function. PDE4 inhibitors in this category include roflumilast and apremilast, which are studied in inflammatory cell signaling. Sildenafil inhibits the cGMP-specific PDE5, and cilostazol is a PDE3 inhibitor. Ibudilast inhibits several families, including PDE3, PDE4, PDE10 and PDE11.

4 Items

  • Reproterol
    Cat. No.
    A41790
    CAS No.
    54063-54-6

    Reproterol

    Reproterol is a dual acting β2-adrenoceptor agonist and phosphodiesterase (PDE) inhibitor. It enhances respiratory function by stimulating β2-adrenoceptors while inhibiting PDE activity, thereby increasing cyclic AMP levels. Reproterol is particularly relevant for research involving asthma and other respiratory conditions, offering insights into therapeutic mechanisms and potential interventions.

    In stock View Details
    1 mg
    $80.00
    5 mg
    $195.00
    All 3 sizes
  • GS-5759
    Cat. No.
    A42071
    CAS No.
    1346653-91-5

    GS-5759

    GS-5759 is a dual-action compound functioning as a β₂-adrenergic receptor agonist and a phosphodiesterase 4 (PDE4) inhibitor. By activating the β₂ receptor, GS-5759 elevates intracellular cAMP levels, resulting in bronchial dilation. Additionally, its inhibition of PDE4 activity decreases cAMP degradation, thereby enhancing anti-inflammatory responses. This compound is relevant for research into respiratory disorders, particularly chronic obstructive pulmonary disease (COPD), demonstrating significant bronchodilatory and anti-inflammatory effects in preclinical models.

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    Out of stock

    All 3 sizes
  • 5,6-DCl-cBIMP
    Cat. No.
    A42193
    CAS No.
    129693-10-3

    5,6-DCl-cBIMP

    5,6-DCl-cBIMP is a cyclic adenosine monophosphate (cAMP) analog that functions as an agonist of phosphodiesterase 2 (PDE2). This compound significantly enhances the hydrolytic activity of PDE2 on both cAMP and cGMP, making it a valuable tool for studying signal transduction pathways. Its potency and specificity position it as a useful reagent in research related to cardiovascular, neurological, and metabolic disorders.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • 5,6-DM-cBIMP
    Cat. No.
    A42251
    CAS No.
    142754-31-2

    5,6-DM-cBIMP

    5,6-DM-cBIMP is a cyclic nucleotide analog that serves as an agonist for phosphodiesterase 2 (PDE2). It is capable of significantly enhancing the hydrolytic activities of cAMP and cGMP by PDE2, making it a valuable tool for researchers investigating the modulation of cyclic nucleotide signaling pathways. Its application is particularly relevant in studies focused on cardiovascular and neurological research.

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    Out of stock

    All 3 sizes

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