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Monoamine oxidase (MAO) inhibitors act on mitochondrial enzymes that inactivate monoamine neurotransmitters. The two isoforms, MAO-A and MAO-B, are flavin adenine dinucleotide (FAD)-containing enzymes bound to the outer mitochondrial membrane. In 1968, studies with the inhibitor clorgyline revealed two forms of brain MAO, later named MAO-A and MAO-B. MAO-A preferentially oxidizes serotonin, whereas MAO-B prefers phenylethylamine and benzylamine. The 2002 crystal structure of human MAO-B showed an entrance cavity and a substrate cavity, which together reach the flavin cofactor. Inhibitors here include the MAO-A inhibitor moclobemide and the MAO-B inhibitors selegiline hydrochloride and rasagiline mesylate. Safinamide mesylate, a reversible MAO-B inhibitor, is used in Parkinson's disease research.
Synonyms: Striverdi Respimat; BI 1744
Olodaterol is a long acting beta-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD), manufactured by Boehringer-Ingelheim.
Synonyms: Mitaban; Taktic; Ovasyn; U 36059; BTS-27419
Amitraz, also known as Mitaban and Taktic, is an alpha-adrenergic receptor agonist and MAO inhibitor used as an insecticide in prevention of flea and tick infections. It prevents prostaglandin synthesis and may inhibit beta-cell insulin release.
TT01001 is a selective and orally active mitoNEET agonist and monoamine oxidase B (MAO-B) inhibitor, with an IC50 of 8.84 μM. It functions by preventing mitoNEET-mediated mitochondrial dysfunction, thus attenuating oxidative stress and neuronal apoptosis. TT01001 has demonstrated potential in improving type II diabetes and enhancing mitochondrial function in murine models. This compound is suitable for research focused on type II diabetes and neurological disorders.
