Amylases

Cat. No.

A59673

CAS No.

127902-33-4

A71378

A71378 is a selective CCK-A receptor agonist with an IC50 of 0.4 nM for the pancreatic CCK-A receptor, and significantly higher IC50 values for the cortical CCK-B and gastrin receptors at 300 nM and 1,200 nM, respectively. This compound effectively stimulates pancreatic amylase secretion with an EC50 of 0.16 nM and induces ileal muscle contraction with an EC50 of 3.7 nM. A71378 is valuable for research applications focusing on gastrointestinal pharmacology and the role of CCK-A receptors in digestive processes.

Cat. No.

A59718

CAS No.

131449-37-1

A-70874

A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (CCK-4), acting as an agonist for pancreatic amylase release. It also serves as a partial agonist, promoting phosphoinositide decomposition in pancreatic cells. With an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor, A-70874 shows a notable affinity of 1.6 μM for the CCK-B/gastrin receptor. This compound is valuable for investigating the physiological roles of CCK receptors in both the digestive system and the central nervous system.

Cat. No.

A62265

CAS No.

141696-11-9

Galanin (2-29) (rat)

Synonyms: Rat galanin(2-29)

Galanin (2-29) (rat) is a selective GAL2R agonist with a Ki of 3.5 nM, exhibiting significant biological activity in modulating peptide secretion. This peptide has been shown to inhibit rat pancreatic protein and CCK-8-stimulated amylase secretion, making it a valuable tool for research on pancreatic function and gastrointestinal regulation. Applications include studies on neuroendocrine signaling and the investigation of galanin receptor pathways.

Cat. No.

A78530

CAS No.

55077-30-0

Aclatonium napadisylate

Aclatonium napadisylate is a cholinergic agonist that enhances amylase release and facilitates Ca2+ efflux. This compound stimulates pancreatic exocrine secretion and promotes gastrointestinal motility and peristalsis. Aclatonium napadisylate is particularly relevant for research into gastrointestinal disorders and associated therapeutic approaches.