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Cholesterol & Lipoprotein Metabolism

Cholesterol and lipoprotein metabolism compounds target sterol synthesis and lipoprotein handling. Cholesterol is built through the mevalonate pathway, which also yields farnesyl and geranylgeranyl pyrophosphate for protein prenylation. Lapaquistat acetate and L-731120 inhibit squalene synthase, the branch point that commits farnesyl pyrophosphate to sterol synthesis. NE 10790 acts on farnesyl pyrophosphate synthase (FPPS), while hGGPPS-IN-1 blocks human geranylgeranyl pyrophosphate synthase. Intracellular sterol transport is addressed by Y18501, an inhibitor of oxysterol-binding protein (OSBP). Pelacarsen sodium is an antisense oligonucleotide directed against apolipoprotein(a), the protein that distinguishes lipoprotein(a) from low-density lipoprotein particles.

1 Item

  • CS-6253
    Cat. No.
    A69529
    CAS No.
    1627911-44-7

    CS-6253

    CS-6253 is an ABCA1 agonist that regulates lipoprotein metabolism and promotes the biogenesis of high-density lipoprotein (HDL), facilitating cellular cholesterol efflux. This compound also exhibits neuroprotective properties and aids in the clearance of amyloid-beta (Aβ) from the brain. CS-6253 is suitable for research focused on cholesterol metabolism and associated conditions, including Alzheimer's disease.

    In stock View Details
    5 mg
    $170.00
    10 mg
    $275.00
    All 2 sizes

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