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HSP

Heat shock protein (HSP) inhibitors, mostly HSP90 inhibitors, block chaperones that fold and stabilize client proteins. HSP90 binds and hydrolyzes adenosine triphosphate (ATP), and many of its clients are kinases and transcription factors in growth signaling. In 1994, benzoquinone ansamycins such as geldanamycin were shown to disrupt HSP90 complexes with the viral Src kinase. A crystal structure reported in 1997 placed geldanamycin in the N-terminal ATP pocket of HSP90. Inhibition leads to degradation of client proteins through the ubiquitin-proteasome pathway. Later chemotypes include the resorcinol-based luminespib and ganetespib, alongside the geldanamycin analog alvespimycin hydrochloride. JG-98 is an allosteric inhibitor of HSP70, a second chaperone family.

2 Items

  • Hsp110/sGC-modulator-1
    Cat. No.
    A37514
    CAS No.
    3056387-72-2

    Hsp110/sGC-modulator-1

    Hsp110/sGC-modulator-1 is a dual-target regulator that modulates Hsp110 and soluble guanylate cyclase (sGC) activities. This compound demonstrates significant inhibitory effects on cell malignancy and promotes vasodilation, making it valuable for cardiovascular research. Additionally, Hsp110/sGC-modulator-1 mitigates pulmonary vascular remodeling and right ventricular hypertrophy through the suppression of Hsp110, highlighting its potential in therapeutic applications for pulmonary hypertension and related disorders.

    In stock View Details
    5 mg
    $150.00
    10 mg
    $250.00
    All 4 sizes
  • Cemdomespib
    Cat. No.
    A37527
    CAS No.
    1450642-92-8

    Cemdomespib

    Synonyms: KU-596

    Cemdomespib is a potent second-generation modulator of Hsp90, known for its high bioavailability. This compound has demonstrated the ability to enhance sensory function in models of diabetic peripheral neuropathy by inducing Hsp70 levels. Its neuroprotective effects are attributed to the activation of the heat shock response, making it a valuable tool for research into neurodegenerative conditions and related therapeutic interventions.

    In stock View Details
    25 mg
    $1,800.00
    50 mg
    $2,285.00
    All 3 sizes

2 Items

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