Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Aldehyde dehydrogenase (ALDH) inhibitors and activators target enzymes that oxidize aldehydes to carboxylic acids. The human ALDH superfamily uses NAD+ as cofactor and includes cytosolic ALDH1A1 and mitochondrial ALDH2. ALDH2 removes acetaldehyde and lipid peroxidation products such as 4-hydroxynonenal. In 2008 the small-molecule activator Alda-1 increased ALDH2 activity and reduced ischemic damage in rat hearts. High ALDH1 activity was reported in 2007 as a marker of normal and malignant human mammary stem cells. NCT-501, NCT-505 and NCT-506 inhibit ALDH1A1 and are used in cancer stem cell studies. RV01 targets ALDH2, while dyclonine hydrochloride and the herbicide propachlor also inhibit ALDH isoforms.
ALDH2 Modulator 1 is a potent modulator of aldehyde dehydrogenase-2 (ALDH2), showcasing effective oral bioavailability. This compound has been demonstrated to significantly reduce blood alcohol levels in murine models, highlighting its potential applications in alcohol metabolism research and related metabolic studies.
ALDH1A1 modulator-1 is a selective modulator of the aldehyde dehydrogenase 1A1 (ALDH1A1) enzyme. This compound exhibits the ability to influence ALDH1A1 activity, which plays a critical role in the detoxification of aldehydes and the metabolic regulation of retinoic acid. ALDH1A1 modulator-1 is valuable for research focused on cancer biology, stem cell differentiation, and metabolic disorders, providing insights into the modulation of ALDH1A1 in various biological contexts.
Out of stock
All 3 sizes