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Cholesterol & Lipoprotein Metabolism

Cholesterol and lipoprotein metabolism compounds target sterol synthesis and lipoprotein handling. Cholesterol is built through the mevalonate pathway, which also yields farnesyl and geranylgeranyl pyrophosphate for protein prenylation. Lapaquistat acetate and L-731120 inhibit squalene synthase, the branch point that commits farnesyl pyrophosphate to sterol synthesis. NE 10790 acts on farnesyl pyrophosphate synthase (FPPS), while hGGPPS-IN-1 blocks human geranylgeranyl pyrophosphate synthase. Intracellular sterol transport is addressed by Y18501, an inhibitor of oxysterol-binding protein (OSBP). Pelacarsen sodium is an antisense oligonucleotide directed against apolipoprotein(a), the protein that distinguishes lipoprotein(a) from low-density lipoprotein particles.

1 Item

  • LY 295427
    Cat. No.
    A75851
    CAS No.
    152755-31-2

    LY 295427

    Synonyms: Agisterol

    LY 295427 is an LDL receptor modulator that acts as a hypocholesterolemic agent by promoting the transcription of the LDL receptor (LDLR). This compound is of particular interest in studies focused on hypercholesterolemia, as it helps to regulate lipid metabolism and lower cholesterol levels. Researchers can utilize LY 295427 to explore its potential therapeutic applications in managing cholesterol-related disorders.

    In stock View Details
    5 mg
    $360.00
    10 mg
    $590.00
    All 5 sizes

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