Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Serine/threonine kinase inhibitors in this group target kinase families that have no dedicated category of their own. Several entries act on with-no-lysine (WNK) kinases, including the pan-WNK inhibitor WNK463 and WNK-IN-11. WNK1 was described in 2000 as a kinase lacking the usual catalytic lysine in subdomain II, which gave the family its name. In 2001 mutations in WNK1 and WNK4 were found to cause an inherited form of human hypertension. SRPIN340 and SPHINX31 inhibit serine/arginine-rich protein kinase 1 (SRPK1), which phosphorylates splicing factors. SGC GAK 1 targets cyclin G-associated kinase (GAK), and LP-935509 inhibits adaptor-associated kinase 1 (AAK1). ML-281 is a small-molecule inhibitor of the less studied serine/threonine kinase 33 (STK33).
TNIK modulator-1 is a selective modulator of TNIK, a protein kinase involved in Wnt signaling pathways and neuronal development. This compound has been shown to enhance neuronal differentiation and may play a role in neurodevelopmental disorders. Its ability to regulate TNIK activity makes it a valuable tool for research in neurobiology, cancer, and regenerative medicine.
Out of stock
All 3 sizes