Glycosidase | Adooq Bioscience

Cat. No.: A75066

CAS No.: 3080715-77-8

β-Glucocerebrosidase modulator 1

β-Glucocerebrosidase modulator 1 is a potent allosteric modulator targeting β-Glucocerebrosidase, with an EC50 of 9.0 μM and a Kd of 0.050 μM. This compound enhances the enzymatic activity of β-Glucocerebrosidase, making it a valuable tool for studying Gaucher disease and related lipid metabolism disorders. Its modulation of enzymatic function assists in elucidating biological pathways and may aid in the development of therapeutic interventions.

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Cat. No.: A75119

CAS No.: 1531606-19-5

OMJ-4

OMJ-4 is a modulator of mutant alpha-mannosidase that enhances its catalytic function. This compound promotes structural changes in the enzyme, increasing both the compactness and flexibility of the active site, which facilitates substrate binding. By inducing greater substrate reactivity, OMJ-4 decreases the activation energy needed for the enzymatic reaction. This reagent is significant for research focused on alpha-mannosidosis and related metabolic disorders.

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Cat. No.: A75153

CAS No.: 1997359-63-3

JZ-4109

JZ-4109 is a potent β-Glucocerebrosidase (GCase) modulator, exhibiting an IC50 of 8 nM against wild-type recombinant GCase. This compound binds to an allosteric site at the GCase dimer interface, promoting dimerization and stabilizing both wild-type and GCase N370S mutant variants. JZ-4109 enhances GCase protein abundance, making it a valuable tool for research into Parkinson's disease and related conditions.

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