Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Phosphodiesterase (PDE) inhibitors prevent the hydrolysis of cyclic nucleotides, second messengers of many receptors. The PDE superfamily comprises 11 families, PDE1 to PDE11, which differ in substrate preference, regulation and tissue distribution. Some families hydrolyze cyclic adenosine monophosphate (cAMP), others cyclic guanosine monophosphate (cGMP), and several act on both. By controlling the amplitude and location of these signals, PDEs shape inflammation, smooth muscle tone and cardiac function. PDE4 inhibitors in this category include roflumilast and apremilast, which are studied in inflammatory cell signaling. Sildenafil inhibits the cGMP-specific PDE5, and cilostazol is a PDE3 inhibitor. Ibudilast inhibits several families, including PDE3, PDE4, PDE10 and PDE11.
Nauclefine is an indole alkaloid derived from Nauclea officinalis, serving as a modulator of phosphodiesterase 3A (PDE3A). This compound has been shown to promote apoptosis in cancer cells via a PDE3A-SLFN12-dependent death pathway. Its biological activity makes Nauclefine a valuable tool for research into cancer therapeutics and the understanding of apoptotic mechanisms.
PDE4B modulator-1 is a selective modulator of phosphodiesterase 4B (PDE4B), targeting intracellular signaling pathways. It exhibits significant inhibition of PDE4B activity, leading to increased cAMP levels and subsequent regulation of various cellular processes. This compound is valuable for research in neurobiology, inflammation, and respiratory diseases, providing insights into PDE4B's role in mediating inflammatory responses and neuronal signaling.
Out of stock
All 3 sizes
PDE11A modulator-1 is a selective modulator targeting phosphodiesterase 11A (PDE11A). This compound enhances intracellular cAMP levels, thereby influencing various signaling pathways. It has potential applications in the study of metabolic disorders and neurological conditions linked to cAMP signaling. PDE11A modulator-1 serves as a valuable tool for researchers investigating the role of PDE11A in cellular processes and therapeutic development.
Out of stock
All 3 sizes