Helicases

Cat. No.

A51916

CAS No.

1428333-96-3

Pritelivir mesylate

Synonyms: AIC316 mesylate; BAY 57-1293 mesylate

Pritelivir mesylate is a selective inhibitor of the viral helicase-primase complex, demonstrating potent antiviral activity against herpes simplex virus (HSV) types 1 and 2 (HSV-1 and HSV-2). With an IC50 of 0.02 μM for HSV-1 and HSV-2, this compound showcases efficacy in both in vitro studies and animal models of HSV infection, making it a valuable tool for research into antiviral therapies targeting herpesviruses.

Cat. No.

A51922

CAS No.

1428321-10-1

Pritelivir mesylate hydrate

Synonyms: AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate

Pritelivir mesylate hydrate is an inhibitor of the helicase-primase complex, demonstrating potent antiviral activity. It is effective against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), with an IC50 of 0.02 μM against HSV-1. This compound is valuable for research applications focusing on therapeutic strategies for herpes virus infections.

Cat. No.

A51926

CAS No.

2305750-23-4

Adibelivir

Synonyms: IM-250

Cat. No.

A53987

CAS No.

3003834-30-5

PBX-7011

PBX-7011 is a camptothecin derivative that targets DDX5 protein. It promotes cell death by inducing degradation of DDX5, showcasing significant biological activity in cellular models. This compound is valuable for research applications focused on cancer therapy and the exploration of apoptosis mechanisms.

Cat. No.

A54613

CAS No.

2973401-72-6

DHX9-IN-21

DHX9-IN-21 is a selective inhibitor of the helicase DHX9, exhibiting an IC50 of 2 nM and a cellular EC50 of 19.1 nM. This compound demonstrates significant antiproliferative activity against LS411N cells, a model of microsatellite unstable colorectal cancer, with an IC50 of 79.2 nM. DHX9-IN-21 is a valuable tool for studying the role of DHX9 in cancer biology and its potential as a therapeutic target in colorectal cancer research.

Cat. No.

B21816

CAS No.

35620-71-4

2-Phenoxynicotinic acid

2-Phenoxynicotinic acid functions as a selective inhibitor of DHX8, an RNA helicase involved in various cellular processes including RNA metabolism and regulation. This compound exhibits key biological activity by modulating DHX8's role in gene expression and RNA splicing, making it valuable for research applications focused on understanding RNA-related mechanisms in diseases. Its oral bioavailability further supports its utility in in vivo studies.