MTH1

Cat. No.

A14291

CAS No.

1374356-45-2

(S)-crizotinib

(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

Cat. No.

A15536

CAS No.

1609960-30-6

TH287

TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16,

Cat. No.

A15537

CAS No.

1609960-31-7

TH588

TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells,

Cat. No.

A37781

CAS No.

2109805-96-9

BAY-707

BAY-707 is a potent and selective inhibitor of MTH1 (NUDT1) that functions through a substrate-competitive mechanism with an IC50 of 2.3 nM. This compound exhibits a favorable pharmacokinetic profile compared to other MTH1 inhibitors and demonstrates good tolerability in mouse models. Although BAY-707 has shown effective inhibition of MTH1, it does not exhibit significant anticancer activity in either in vitro or in vivo studies, making it suitable for research into MTH1 function and related pathways.

Cat. No.

A38163

CAS No.

901044-91-5

MTH1-IN-2

MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), a target implicated in cancer biology. This compound exhibits significant anti-tumor activity, making it a valuable tool for cancer research. MTH1-IN-2 can be utilized to investigate the mechanisms of tumorigenesis and to develop therapeutic strategies that exploit the MTH1 pathway.

Cat. No.

A38267

CAS No.

1884209-98-6

IACS-4619

IACS-4619 is a highly selective inhibitor of the MTH1 enzyme (MutT homolog 1) with an IC50 of 0.2 nM. This 2-aminopyrimidine compound effectively blocks the hydrolysis of oxidized purine nucleotides, such as 8-oxo-dGTP, preventing the incorporation of these nucleotides into DNA. Notably, IACS-4619 demonstrates significant inhibition of endogenous MTH1 activity in MTH1-overexpressing U2OS cells without exhibiting antiproliferative or cytotoxic effects on various human cancer and normal cell lines. This reagent is applicable in oncology research targeting the MTH1 pathway.

Cat. No.

A38322

CAS No.

2598151-90-5

SU0383

SU0383 is a dual inhibitor of MTH1 and OGG1, demonstrating IC50 values of 0.034 μM and 0.49 μM, respectively. This compound induces cytotoxicity in cancer cells and enhances their sensitivity to oxidative stress, while exhibiting minimal toxicity in normal cells. SU0383 is suitable for applications in cancer research, particularly in studies focused on oxidative stress responses and therapeutic strategies targeting DNA repair mechanisms.

Cat. No.

A38702

CAS No.

1884209-99-7

IACS-4759

IACS-4759 is a potent and selective inhibitor of MTH1 (MutT homolog 1), with an IC50 value of 0.6 nM. This compound exhibits significant anti-cancer activity by disrupting the repair of damaged nucleotides, thereby inducing metabolic stress in cancer cells. IACS-4759 is useful for research applications focused on cancer metabolism and the development of targeted cancer therapies.

Cat. No.

A38755

CAS No.

1638211-05-8

TH287 hydrochloride

TH287 hydrochloride is a highly potent and selective inhibitor of MTH1, exhibiting an IC50 of 0.8 nM. It demonstrates significant selectivity for MTH1 over related enzymes, showing no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase, and ITPA at concentrations of 100 µM. This compound is valuable for cancer research, particularly in the exploration of novel chemotherapeutic strategies targeting MTH1's role in tumor metabolism.

Cat. No.

A39260

CAS No.

139307-94-1

8-Oxo-dGTP

Synonyms: 8-Oxo-Deoxyguanosine triphosphate

8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) is a reactive oxidized guanine nucleotide that serves as a substrate for MTH1 and other pyrophosphohydrolases. This compound is known to act as a mutagen, integrating into DNA and leading to A:T to C:G transversions, which can contribute to genomic instability. Additionally, 8-Oxo-dGTP can provoke oxidative DNA modifications, strand breaks, and the promotion of apoptosis, particularly in mth1-deficient organisms. Its accumulation is linked to various biological processes and is extensively utilized in research on carcinogenesis, neurodegenerative diseases, and other pathologies.