- Cat. No.
- A10035
Acitretin
Synonyms: Soriatane; Neotigason
Acitretin is a second generation retinoid and is typically used for psoriasis.
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- Cat. No.
- A10038
Adapalene
Synonyms: Differin
Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.
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- Cat. No.
- A10485
Isotretinoin
Synonyms: Accutane; Amnesteem; Claravis; Sotret; 13-cis-Retinoic Acid
Isotretinoin was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
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- Cat. No.
- A10894
Tazarotene
Tazarotene is a prodrug and a member of the acetylenic class of retinoids.
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- Cat. No.
- A10944
Tretinoin (Retinoic acid)
Synonyms: Retinoic Acid; ATRA; Vitamin A Acid
Tretinoin is an endogenous agonist for retinoic acid receptors with IC50 value of 14 nM for RAR-alpha, RAR-beta and RAR-gamma receptors).
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- Cat. No.
- A11094
Bexarotene (LGD1069)
Synonyms: LGD 1069; SR 11247; Ro 26-4455; Targretin; LG 100069
Bexarotene is a highly selective retinoid X receptor (RXR) agonist.
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- Cat. No.
- A11298
Adarotene (ST1926)
Synonyms: ST 1926
Adarotene belongs to the so-called class of atypical retinoids. The presence of the phenolic hydroxyl group on Adarotene structure allows a rapid O-glucuronidation as a major mechanism of elimination of the drug, favoring a fast excretion of its glucuronide metabolite in the urines.
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- Cat. No.
- A11589
Tamibarotene
Synonyms: Am80
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro.
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- Cat. No.
- A11792
AM 580
Synonyms: CD 336; NSC 608001; Ro 40-6055
AM 580 is an analog of retinoic acid that acts as a selective RARα agonist.
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- Cat. No.
- A11793
CD 437
Synonyms: AHPN
CD 437 is a synthetic retinoid that is an RARγ-selective agonist.
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- Cat. No.
- A12163
Fenretinide
Synonyms: 4-HPR; (4-Hydroxyphenyl)retinamide
Fenretinide is a synthetic retinoid agonist. It is an antiproliferative, antioxidant and anticancer agent with a long half-life in vivo.
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- Cat. No.
- A12430
Palovarotene
Palovarotene is a novel retinoic acid receptor gamma agonist for the treatment of emphysema
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- Cat. No.
- A12905
AR7
AR7 was developed as a highly potent and selective enhancer of the chaperone-mediated autophagy (CMA) through antagonizing RARα.
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- Cat. No.
- A13007
TTNPB
Synonyms: Arotinoid acid; Ro 13-7410
TTNPB enhances reprogramming efficiency in chemically induced pluripotent stem cells (CiPSCs).
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- Cat. No.
- A14081
AGN194204
Synonyms: IRX4204; NRX194204; VTP 194204
AGN194204 is a selective retinoid X receptor (RXR) agonist with high affinity, exhibiting Kd values of 0.4 nM, 3.6 nM, and 3.8 nM for RXRα, RXRβ, and RXRγ, respectively, and EC50 values of 0.2 nM, 0.8 nM, and 0.08 nM. This compound is devoid of activity against retinoic acid receptors (RAR). AGN194204 demonstrates significant anti-inflammatory and anticarcinogenic properties, making it a valuable tool for research in inflammation and cancer biology.
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- Cat. No.
- A14127
LG 100268
Synonyms: AGN 192620; ALRT 268,CD 3127; LG 268; LGD 100268; LGD 1268
LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).
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- Cat. No.
- A16292
AGN 194310
Synonyms: VTP194310
AGN 194310 is a potent and selective pan-RARs agonist with Kd values of 3/2/5 nM for RARα/β/γ respectively.
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- Cat. No.
- A16293
AGN 195183
AGN 195183 is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ.
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- Cat. No.
- A16294
AGN 196996
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).
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- Cat. No.
- A16295
AGN 205327
AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR.
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- Cat. No.
- A16296
AGN 205728
AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.
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- Cat. No.
- A16356
Etretinate
Synonyms: Ro 10-9359
Etretinate is a second-generation retinoid to treat severe psoriasis; has been replaced by acitretin, a safer metabolite of etretinate.
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- Cat. No.
- A17538
D-Arabinopyranose
D-Arabinopyranose is a rare aldo-pentose that serves as a precursor to D-arabinose in its open-chain form. This compound exhibits significant biological activity, including antidepressant effects and growth inhibition in Caenorhabditis elegans with an IC50 of 7.5 mM. D-Arabinose penetrates the blood-brain barrier, specifically modulating the metabolism of D-ribose and D-fructose, while also demonstrating antibacterial properties by inhibiting biofilm synthesis. Additionally, it activates the ACSS2-PPARγ/TFEB-CRTC1 axis via the lysosomal AXIN-LKB1-AMPK pathway, leading to antidepressant-like outcomes.
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- Cat. No.
- A18305
Adapalene sodium salt
Synonyms: CD 271 sodium salt
Adapalene sodium salt is a potent retinoic acid receptor (RAR) agonist, demonstrating significant binding affinity with AC50 values of 2.3 nM for RARβ, 9.3 nM for RARγ, and 22 nM for RARα. This third-generation synthetic retinoid is primarily utilized in acne research but has also been identified to inhibit the enzymatic activity of glutamate oxaloacetate transaminase 1 (GOT1) in a non-competitive manner. Additionally, adapalene sodium salt exhibits anti-tumor activity, making it valuable for diverse biological studies.
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- Cat. No.
- A19001
WYC-209
WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist.
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