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Dengue virus inhibitors target viral enzymes, replication proteins and host factors of this mosquito-borne flavivirus. Dengue virus (DENV) has a positive-strand RNA genome that is translated into one polyprotein and cleaved into individual proteins. ZINC03129319 and rhodiolin are listed as inhibitors of the protease formed by nonstructural proteins 2B and 3 (NS2B-NS3). NITD008 is an adenosine nucleoside analog that terminates viral RNA synthesis and was reported in 2009 to inhibit all four DENV serotypes. (+)-JNJ-A07 belongs to a compound series that blocks the interaction between NS3 and nonstructural protein 4B (NS4B). U18666A inhibits cholesterol synthesis and transport, host lipid pathways that the virus uses. Compounds with broader activity across related viruses are listed in the neighboring Flavivirus category.
2A/2B Dengue protease substrate (Ac-RTSKKR-pNA) is a polypeptide substrate designed for the Dengue NS2B-NS3 protease. This substrate facilitates the understanding of protease activity by serving as a valuable tool in the development of selective inhibitors targeting the Dengue NS2B-NS3 protease. Its efficacy in research applications enhances the study of dengue virus pathogenesis and potential therapeutic strategies.
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Ac-EVKKQR-pNA is a competitive chromogenic para-nitroanilide substrate designed to probe the NS2B-NS3 cleavage site. This reagent includes a readily hydrolyzable para-nitroanilide at the P1’ position, enhancing its reactivity. It is primarily used in studies of dengue virus type 2 and other flavivirus infections, facilitating the exploration of viral protease activity and potential therapeutic interventions.
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