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Flavivirus inhibitors target replication enzymes of dengue, Zika and related viruses. Flaviviruses are enveloped, positive-strand RNA viruses whose genome is translated into a single polyprotein. The viral protease formed by non-structural (NS) proteins NS2B and NS3 cleaves this polyprotein, and NS5 carries the RNA-dependent RNA polymerase (RdRp). NITD008, an adenosine nucleoside analog, was described in 2009 as an inhibitor of dengue virus replication. CN-716 dihydrochloride targets the NS2B-NS3 protease, and HeE1-2Tyr is listed as an RdRp inhibitor. DEPN-8 is listed as a substrate for measuring West Nile virus protease activity in enzyme assays. Compounds studied mainly against one virus also appear in the neighboring Dengue Virus category.
Ac-EVKKQR-pNA is a competitive chromogenic para-nitroanilide substrate designed to probe the NS2B-NS3 cleavage site. This reagent includes a readily hydrolyzable para-nitroanilide at the P1’ position, enhancing its reactivity. It is primarily used in studies of dengue virus type 2 and other flavivirus infections, facilitating the exploration of viral protease activity and potential therapeutic interventions.
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