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Human immunodeficiency virus (HIV) inhibitors block viral entry, integration, polyprotein processing and maturation. HIV is a retrovirus that copies its RNA genome into DNA and inserts this DNA into a host cell chromosome. Protease inhibitors such as nelfinavir and saquinavir bind the viral aspartyl protease and prevent cleavage of the Gag and Gag-Pol polyproteins. Integrase strand transfer inhibitors, including raltegravir and bictegravir, block the insertion of viral DNA into host DNA. Bevirimat is a maturation inhibitor that prevents a late cleavage step in Gag needed for mature capsid formation. Fostemsavir, a prodrug of temsavir, prevents the envelope glycoprotein gp120 from attaching to host cells.
Fluorescent HIV Substrate is specifically designed to facilitate the study of HIV protease activity. This highly sensitive substrate emits fluorescence upon cleavage by the HIV protease, enabling real-time monitoring of enzymatic activity. It serves as an essential tool in HIV research, helping to evaluate protease inhibitors and advance therapeutic strategies against HIV infection.
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HIV Protease Substrate IV is a specific substrate designed for HIV protease. It facilitates the quantitative assessment of HIV-1 protease activity, enabling researchers to study the enzyme's function and evaluate potential inhibitors. This substrate is particularly useful in the development of antiviral therapies targeting HIV protease, contributing to the understanding of HIV pathogenesis and treatment strategies.
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HIV-1, HIV-2 Protease Substrate is a specific substrate designed for the enzymatic activity of HIV-1 and HIV-2 proteases. This substrate contains four residues that allow for conservative substitutions, facilitating studies on substrate binding and protease activity. It is a valuable tool for research focused on HIV protease function and the development of antiviral therapies.
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HIV Protease Substrate 1 is a fluorogenic substrate specifically designed for the study of HIV protease activity. This reagent allows for the quantitative assessment of enzymatic function, facilitating investigations into HIV protease inhibitors and their effects on viral replication. It is particularly useful in the development of antiviral therapies and for studying the proteolytic processing of HIV proteins.
HIV Protease Substrate I is a chromogenic substrate specifically designed for the HIV-1 protease. It contains the optimal cleavage site recognized by the enzyme, enabling accurate assessment of protease activity. This substrate is valuable for studying HIV-1 protease function and kinetics, as well as for evaluating the efficacy of protease inhibitors in research applications.
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Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate specifically designed for assessing the activity of HIV-1 protease. This compound exhibits a strong interaction with the enzyme, facilitating the measurement of protease activity in research applications related to HIV-1 pathogenesis and antiviral drug development. Its utility in protease assays makes it a valuable tool for studying HIV-1 enzymatic function and evaluating potential therapeutic interventions.
Out of stock
All 3 sizes