Influenza Virus

Influenza virus inhibitors act on viral RNA synthesis, nucleoprotein function, the M2 ion channel and host factors. Influenza A and B viruses carry a segmented, negative-sense RNA genome that is transcribed and replicated in the nucleus of infected cells. Favipiravir, a pyrazinecarboxamide, is converted in cells into a ribonucleotide form that inhibits the viral RNA-dependent RNA polymerase. Amantadine hydrochloride blocks the M2 proton channel of influenza A virus, a step required for release of the viral genome. Nucleozin binds the viral nucleoprotein and causes it to aggregate, which prevents its accumulation in the nucleus. Host-directed compounds include SC75741, an inhibitor of nuclear factor kappa B (NF-κB) signaling, and the heat shock protein 90 (Hsp90) inhibitor geldanamycin.

3 Items

  • 4-MUNANA
    Cat. No.
    A44460

    4-MUNANA

    4-MUNANA is a highly selective fluorescent substrate for influenza virus neuraminidase (NA), undergoing an irreversible enzymatic reaction that releases fluorescent 4-methylumbelliferone (4-MU). The fluorescence intensity of 4-MU provides a quantitative measure of NA activity, making 4-MUNANA a valuable tool in influenza research. Applications include screening for neuraminidase inhibitors, creating new anti-influenza therapies, and investigating the infection mechanisms of influenza viruses.

    1 mg
    $25.00
    5 mg
    $65.00
    All 6 sizes
  • Submandibular mucin
    Cat. No.
    A86614

    Submandibular mucin

    Submandibular mucin serves as a substrate for the viral enzyme neuraminidase, characterized by its high molecular weight glycoprotein structure. This compound exhibits key biological activities relevant to the study of viral infections, particularly in the context of influenza research. Its applications include investigating the enzymatic activity of neuraminidase and examining mucin interactions with viral pathogens.

    50 mg
    $55.00
    100 mg
    $80.00
    All 3 sizes
  • Biotin-DADOO
    Cat. No.
    A86688

    Biotin-DADOO

    Synonyms: Biotinyl-3,6-dioxaoctanediamine; EZ-Link Amine-PEO2-Biotin

    Biotin-DADOO is a biotinylation reagent that facilitates the covalent attachment of biotin to various substrates. It acts as an amino component in the nucleophilic ring-opening reaction of epoxidized ω-double bonds, enabling the synthesis of biotinylated inhibitor derivatives. Additionally, Biotin-DADOO can be conjugated with carboxymethyl cellulose derivatives and is utilized in the development of biotin-estradiol conjugates for enzyme immunoassays. This reagent is also relevant in the study of influenza A research.

    25 mg
    $25.00
    50 mg
    $30.00
    All 6 sizes

3 Items

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