RSV

GS-646089 is a potent inhibitor of respiratory syncytial virus (RSV) RNA-dependent RNA polymerase (RdRp). This broad-spectrum antiviral nucleoside analog demonstrates robust activity against RSV, human metapneumovirus (hMPV), rhinovirus, and enteroviruses, with an IC50 in the range of 43 to 46 nM. GS-646089 is converted intracellularly into a triphosphate metabolite that competes with ATP for incorporation into growing RNA chains, effectively terminating viral replication. This compound serves as a valuable tool for research into acute respiratory viral infections and related viral pathogens.

CL-A3-7 is a potent respiratory syncytial virus (RSV) inhibitor that targets the RSV F protein, functioning as a virus-cell fusion inhibitor. By disrupting the interaction between the virus and the host insulin-like growth factor 1 receptor (IGF1R), CL-A3-7 effectively prevents infections caused by both wild-type RSV and the K394R variant. This compound is valuable for use in anti-RSV drug development and studies focused on resistance mechanisms associated with RSV.