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α-synuclein

α-Synuclein inhibitors and degraders act on a presynaptic protein that aggregates in Parkinson's disease. α-Synuclein (SNCA) is a small, natively unfolded protein that associates with membranes and synaptic vesicles. In 1997 a point mutation in its gene was found in families with inherited Parkinson's disease. The same year it was detected as a major component of Lewy bodies, the protein inclusions typical of the disease. Misfolded α-synuclein forms oligomers and amyloid fibrils, which are studied in aggregation assays, neuronal cells and transgenic animals. SynuClean-D and PBT434 mesylate are listed as aggregation inhibitors, minzasolmin as an oligomerization inhibitor and CLR01 sodium as a molecular tweezer. Proteolysis-targeting chimeras (PROTACs) such as PROTAC α-synuclein degrader 3 direct the protein to proteasomal degradation.

1 Item

  • MK-7337
    Cat. No.
    A79420
    CAS No.
    3056154-69-6

    MK-7337

    MK-7337 is an α-synuclein PET ligand, designed for targeted imaging in neurodegenerative disorders. Radiolabeled with carbon-11, MK-7337 serves as a positron emission tomography (PET) tracer, enabling detailed visualization of α-synuclein aggregation in the brain. This compound is valuable for advancing research and understanding the biochemical underpinnings of conditions such as Parkinson's disease.

    In stock View Details
    1 mg
    $185.00
    5 mg
    $470.00
    All 6 sizes

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