Amyloid-β

Cat. No.

A20379

CAS No.

1201323-97-8

MK-3328

MK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC50 of 10.5 nM.

Cat. No.

A78231

CAS No.

566169-93-5

Pittsburgh Compound B

Synonyms: PiB; 6-OH-BTA-1

Pittsburgh Compound B (PiB) is a targeted β-amyloid (Aβ) binder, designed as a PET tracer for the visualization of Aβ deposition in the brain. It exhibits a high affinity for Aβ(1-40) fibrils with a Ki value of 678.4 nM. The compound can be modified using click chemistry, allowing for the development of fluorescent conjugates for applications in fluorescence imaging and ultrastructural studies. Pittsburgh Compound B is particularly relevant for research focusing on Alzheimer's disease and the characterization of Aβ complexes.

Cat. No.

A78257

CAS No.

149204-50-2

MG-H1

MG-H1 is a ligand for the receptor for advanced glycation end products (RAGE), exhibiting a binding affinity (Kd) of 4.12 nM. It interacts specifically with human umbilical vein endothelial cells, making it a valuable tool for studying endothelial dysfunction. MG-H1 is particularly relevant in the context of diabetes research, where it aids in understanding the mechanisms of vascular complications associated with the disease.

Cat. No.

A78266

CAS No.

6314-40-5

Aβ42 agonist-2

Aβ42 agonist-2 is a small molecule compound designed to target Aβ42 ligands. It facilitates the aggregation of Aβ42 by promoting the self-assembly of nontoxic aggregates and accelerating fibril formation through interactions with Aβ42 oligomers and pentamers. Additionally, Aβ42 agonist-2 has been shown to mitigate Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells, making it a valuable tool for investigating Alzheimer’s disease pathology and potential therapeutic strategies.

Cat. No.

A78271

CAS No.

112269-92-8

4-Sulfocalix[4]arene

Synonyms: para-Sulfonatocalix[n]arene

4-Sulfocalix[4]arene is an amyloid-beta 42 binder that exhibits a dissociation constant (Kd) of 5.39 µM, indicating a strong affinity for binding to this protein. Its ability to inhibit amyloid β-peptide fibrillation makes it a valuable tool in research focused on Alzheimer's disease pathology. Additionally, 4-Sulfocalix[4]arene can reduce the cytotoxicity associated with amyloid aggregates, providing insights for therapeutic strategies targeting amyloid-related neurodegeneration.

Cat. No.

A78279

CAS No.

50635-12-6

Aβ42 agonist-1

Aβ42 agonist-1 is a selective ligand targeting Aβ42, facilitating the aggregation of Aβ42 peptides. This compound interacts with Aβ42 oligomers and pentamers, promoting the self-assembly of nontoxic aggregates and accelerating the formation of fibrils. Additionally, Aβ42 agonist-1 effectively inhibits Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells, making it a valuable tool for research into Alzheimer's disease mechanisms and therapeutic strategies.

Cat. No.

A78373

CAS No.

1573029-17-0

THK-523

THK-523 is a selective tau imaging ligand that targets tau pathology associated with neurodegenerative disorders, particularly Alzheimer's disease. Demonstrating high affinity and specificity, THK-523 is effective as an in vivo radiotracer, facilitating the imaging of tau aggregates. Its applications extend to research in tau-related pathologies, aiding in the understanding of tau's role in neurodegeneration and the development of potential therapeutic strategies.

Cat. No.

A78397

CAS No.

3056154-68-5

α-Synuclein aggregate binder 2

α-Synuclein aggregate binder 2 is a specific binder for alpha-synuclein, exhibiting a binding affinity characterized by a Ki of 1.6 nM. This compound demonstrates a weaker interaction with β-amyloid aggregates, with a Ki of 295 nM. It is valuable in research applications focused on Parkinson's disease, serving as a tracer to investigate alpha-synuclein aggregation and its implications in neurodegenerative disorders.

Cat. No.

A78406

CAS No.

4952-56-1

Caprospinol

Synonyms: SP-233

Caprospinol is a potent σ-1 receptor ligand that exhibits neuroprotective properties through multiple mechanisms. It effectively binds to β-amyloid protein (Aβ(42)), interacts with the mitochondrial respiratory chain, and facilitates the clearance of Aβ(42) monomers. Caprospinol is capable of crossing the blood-brain barrier, thereby showing promise in restoring cognitive function and inhibiting the progression of Alzheimer's disease. Its diverse biological activities make it a valuable tool for research in neurodegenerative disorders.