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CaMK

CaMK inhibitors block calcium- and calmodulin-dependent protein kinases (CaMKs) in calcium signaling. Calcium/calmodulin-dependent protein kinase II (CaMKII), a multisubunit enzyme abundant at synapses, is central to synaptic strengthening and memory formation, as reviewed in 2002. KN-93, first reported in 1991, and the related isoquinolinesulfonamide KN-62 are classical CaMKII inhibitors. The set also lists KN-93 phosphate and (E)-KN-93 phosphate, salt forms of the same inhibitor. A-484954 targets eukaryotic elongation factor 2 kinase (eEF2K), historically called CaMK III, which controls protein synthesis. The category is mixed and contains protein kinase D (PKD) inhibitors such as kb NB 142-70 and CID 755673, which act on related kinases.

1 Item

  • PTCA
    Cat. No.
    A78513
    CAS No.
    871326-47-5

    PTCA

    PTCA is a potent ligand for calcium/calmodulin-dependent protein kinase II alpha (CaMKIIα), exhibiting a pKi value of 7.2. This compound effectively modulates CaMKIIα activity, making it valuable for research into calcium signaling pathways and their implications in neuronal functions and synaptic plasticity. Its use in biochemical assays facilitates the exploration of CaMKIIα's role in various physiological and pathological processes.

    In stock View Details
    25 mg
    $115.00
    50 mg
    $180.00
    All 3 sizes

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