Tau Protein

Cat. No.

A78373

CAS No.

1573029-17-0

THK-523

THK-523 is a selective tau imaging ligand that targets tau pathology associated with neurodegenerative disorders, particularly Alzheimer's disease. Demonstrating high affinity and specificity, THK-523 is effective as an in vivo radiotracer, facilitating the imaging of tau aggregates. Its applications extend to research in tau-related pathologies, aiding in the understanding of tau's role in neurodegeneration and the development of potential therapeutic strategies.

Cat. No.

A79333

CAS No.

1565797-16-1

Florzolotau

Synonyms: APN1607; PM-PBB3

Florzolotau is a tau ligand designed for positron emission tomography (PET) imaging, targeting the β-sheet region of paired helical filaments (PHFs) and straight filaments (SFs) of tau protein. Its binding affinity extends to intraneuronal inclusions present in Alzheimer's disease, primary age-related tauopathy, and posterior cortical atrophy. This compound shows significant potential in the diagnosis and study of tau proteinopathies, facilitating improved imaging of neurological disorders associated with tau aggregation.

Cat. No.

A79337

CAS No.

3063166-64-0

Tau ligand-1

Tau Ligand-1 is a specific ligand that targets aggregated tau protein and is capable of crossing the blood-brain barrier. Demonstrating high affinity for aggregated tau in brain tissues from Alzheimer's disease and other tauopathies, it displays equilibrium dissociation constant (KD) values between 1 and 3.8 nM. This compound shows potential as a positron emission tomography (PET) tracer, offering valuable applications in imaging studies related to tau-associated neurodegenerative diseases in the central nervous system.

Cat. No.

A79341

CAS No.

2101218-44-2

THK5351 (R enantiomer)

THK5351 (R enantiomer) is a selective ligand for the translocator protein (TSPO), which is involved in neuroinflammation. This compound exhibits high affinity for TSPO and is utilized in research related to neurodegenerative diseases, allowing for the visualization of neuroinflammatory processes in vivo. THK5351 (R enantiomer) serves as an invaluable tool in studying the role of inflammation in the pathogenesis of disorders such as Alzheimer's disease and other neurodegenerative conditions.

Cat. No.

A79342

CAS No.

1707147-26-9

THK5351

THK5351 is a selective radiolabeled ligand targeting tau pathology in the brain. This compound serves as a radiotracer for in vivo imaging, facilitating the study of tau-related neurodegenerative diseases such as Alzheimer's. The application of THK5351 in research enables the visualization and quantification of tau aggregation, providing essential insights into disease progression and potential therapeutic interventions.

Cat. No.

A79351

CAS No.

1320211-61-7

T808

T808 is a selective ligand targeting tau protein, crucial in Alzheimer's disease research. This compound can be utilized to synthesize [18F]-T808, a highly selective tau protein positron emission tomography (PET) tracer, facilitating in vivo imaging studies. Additionally, T808 serves in the synthesis of [3H]-T808, a radioactive marker suitable for in vitro experiments, further advancing our understanding of tau-related pathologies.

Cat. No.

A79356

CAS No.

2417159-58-9

Aberrant tau ligand 2

Aberrant tau ligand 2 (Compound 4-12) selectively targets the tau protein, serving as a crucial ligand in research on tau pathology. This compound plays an essential role in the development of PROTAC degraders, specifically for the synthesis of C004019, facilitating studies on tau-related neurodegenerative diseases. Its application in the exploration of targeted protein degradation highlights its significance in advancing therapeutic strategies.

Cat. No.

A79370

CAS No.

2173357-28-1

JNJ-64326067

JNJ-64326067 is an aggregated tau protein binder with a Ki of 2.4 nM, demonstrating significant blood-brain barrier permeability. This compound selectively targets aggregated tau protein while exhibiting no binding affinity for aggregated β-amyloid or off-target interactions with various receptors, ion channels, transporters, kinases, and monoamine oxidases. JNJ-64326067 is a valuable tool for investigating the pathophysiology of Alzheimer's disease and exploring potential therapeutic strategies.

Cat. No.

A79376

CAS No.

3046416-94-5

Tau ligand-2

Tau ligand-2 is a selective tau aggregate ligand with a Ki value of 0.99 nM. Radiolabeled with fluorine-18, this compound serves as a positron emission tomography (PET) tracer, enabling the visualization of tau pathology. Tau ligand-2 is particularly relevant for research on Alzheimer's disease and other tauopathies, aiding in the understanding of neurodegenerative processes.

Cat. No.

A79383

CAS No.

2567913-75-9

MG-1102

MG-1102 is a first-in-class dual binder targeting both monomeric tau and pre-miRNA-146a. It exhibits specific inhibition of pre-miRNA-146a, with IC50 values of 0.21 mM for double-labeled and 0.36 mM for mono-labeled forms. Additionally, MG-1102 shows a binding affinity for tau monomers, characterized by a Kd of 3.21 mM as determined by surface plasmon resonance (SPR). This compound serves as a potential multi-target-directed ligand (MTDL) for research applications related to Alzheimer’s disease.

Cat. No.

A81281

CAS No.

1892461-96-9

Aberrant tau ligand 1

Aberrant tau ligand 1 is a specific ligand targeting abnormal tau proteins. This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) designed for the degradation of aberrant tau, enabling research into tau-related pathologies. It is a valuable tool for studying tau protein dynamics and their implications in neurodegenerative diseases.